2ETR

Crystal Structure of ROCK I bound to Y-27632

Summary for 2ETR

• Entry DOI: 10.2210/pdb2etr/pdb
• Related: 2ERZ 2ESM 2ETK 2ETO
• Descriptor: Rho-associated protein kinase 1, (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE (3 entities in total)
• Functional Keywords: dimerization, dimer, phosphorylation, kinase, yoshitomi, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q13464
• Total number of polymer chains: 2
• Total formula weight: 96519.24

Authors

Jacobs, M. (deposition date: 2005-10-27, release date: 2005-11-08, Last modification date: 2023-08-23)

• Primary citation: Jacobs, M.,Hayakawa, K.,Swenson, L.,Bellon, S.,Fleming, M.,Taslimi, P.,Doran, J.; The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity.; J.Biol.Chem., 281:260-268, 2006; PubMed: 16249185; DOI: 10.1074/jbc.M508847200

Experimental method

X-RAY DIFFRACTION (2.6 Å)