2BCJ

Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits

Summary for 2BCJ

Entry DOI	10.2210/pdb2bcj/pdb
Related	1OMW 1YM7
Descriptor	G-protein-coupled receptor kinase 2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (8 entities in total)
Functional Keywords	peripheral membrane complex, protein kinase, rgs domain, wd40 protein, heterotrimeric g protein, transferase-hydrolase complex, transferase/hydrolase
Biological source	Bos taurus (Bovine) More
Cellular location	Cytoplasm : P21146 Cell membrane ; Lipid-anchor ; Cytoplasmic side : P63212 Nucleus : P21279
Total number of polymer chains	4
Total formula weight	166776.15
Authors	Tesmer, J.J.G. (deposition date: 2005-10-19, release date: 2005-12-20, Last modification date: 2023-08-23)
Primary citation	Tesmer, V.M.,Kawano, T.,Shankaranarayanan, A.,Kozasa, T.,Tesmer, J.J.G. Snapshot of Activated G Proteins at the Membrane: The Gq-GRK2-G Complex Science, 310:1686-1690, 2005 Cited by PubMed: 16339447 DOI: 10.1126/science.1118890 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.061 Å)

Structure validation