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6W0U	HIV Integrase core domain in complex with inhibitor 2-(2-ethynyl-5-methyl-1-benzofuran-3-yl)acetic acid Descriptor: 2-(2-ethynyl-5-methyl-1-benzofuran-3-yl)ethanoic acid, IODIDE ION, Integrase, ... Authors: Gorman, M.A, Parker, M.W. Deposit date: 2020-03-02 Release date: 2021-03-03 Method: X-RAY DIFFRACTION (2.19 Å) Cite: HIV Integrase core domain in complex with inhibitor To Be Published
6W42	HIV Integrase core domain in complex with inhibitor 2-(5-methyl-2-(2-(thiophen-2-yl)ethynyl)-1-benzofuran-3-yl)acetic acid Descriptor: 2-[5-methyl-2-(2-thiophen-2-ylethynyl)-1-benzofuran-3-yl]ethanoic acid, HIV Integrase catalytic domain, IODIDE ION, ... Authors: Gorman, M.A, Parker, M.W. Deposit date: 2020-03-09 Release date: 2021-03-10 Method: X-RAY DIFFRACTION (2.26 Å) Cite: HIV Integrase core domain in complex with inhibitor (5-methyl-1-benzofuran-3-yl)acetic acid To Be Published
8D3S	HIV-1 Integrase Catalytic Core Domain F185H Mutant Complexed with BKC-110 Descriptor: (2S)-tert-butoxy{4-(4-chlorophenyl)-2,6-dimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid, Integrase Authors: Dinh, T, Kvaratskhelia, M. Deposit date: 2022-06-01 Release date: 2023-06-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.84 Å) Cite: HIV-1 Integrase Catalytic Core Domain Complexed with BKC-110 To Be Published
6WC8	HIV Integrase core domain in complex with inhibitor 2-(5-(3-fluorophenyl)-2-(2-(thiophen-2-yl)ethynyl)-1- benzofuran-3-yl)ethanoic acid Descriptor: IODIDE ION, Integrase, SULFATE ION, ... Authors: Gorman, M.A, Parker, M.W. Deposit date: 2020-03-29 Release date: 2021-03-31 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.88 Å) Cite: HIV Integrase core domain in complex with inhibitor To Be Published
6WE7	HIV Integrase core domain in complex with inhibitor 3-methyl-2-{5-methyl-2-[2-(thiophen-2-yl)ethynyl]-1- benzofuran-3-yl}butanoic acid Descriptor: (2S)-3-methyl-2-{5-methyl-2-[(thiophen-2-yl)ethynyl]-1-benzofuran-3-yl}butanoic acid, IODIDE ION, Integrase, ... Authors: Gorman, M.A, Parker, M.W. Deposit date: 2020-04-01 Release date: 2021-04-07 Method: X-RAY DIFFRACTION (2.28 Å) Cite: HIV Integrase core domain in complex with inhibitor To Be Published
3KKR	Crystal structure of catalytic core domain of BIV integrase in crystal form I Descriptor: Integrase, NITRATE ION Authors: Shen, Y. Deposit date: 2009-11-06 Release date: 2010-09-22 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.453 Å) Cite: Crystal structures of catalytic core domain of BIV integrase: implications for the interaction between integrase and target DNA Protein Cell, 1, 2010
3KKS	Crystal structure of catalytic core domain of BIV integrase in crystal form II Descriptor: ACETATE ION, GLYCEROL, Integrase Authors: Shen, Y. Deposit date: 2009-11-06 Release date: 2010-09-22 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structures of catalytic core domain of BIV integrase: implications for the interaction between integrase and target DNA Protein Cell, 1, 2010
3L3V	Structure of HIV-1 integrase core domain in complex with sucrose Descriptor: CADMIUM ION, POL polyprotein, SULFATE ION, ... Authors: Wielens, J, Chalmers, D.K, Scanlon, M.J, Parker, M.W. Deposit date: 2009-12-18 Release date: 2010-03-31 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site Febs Lett., 584, 2010
3L3U	Crystal structure of the HIV-1 integrase core domain to 1.4A Descriptor: POL polyprotein, SULFATE ION Authors: Wielens, J, Chalmers, D.K, Scanlon, M.J, Parker, M.W. Deposit date: 2009-12-17 Release date: 2010-03-31 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site. Febs Lett., 584, 2010
3LPU	HIV integrase Descriptor: (2S)-2-(6-chloro-2-methyl-4-phenylquinolin-3-yl)pentanoic acid, 2-[3-[3-(2-hydroxyethoxy)propoxy]propoxy]ethanol, CALCIUM ION, ... Authors: Nicolet, S, Christ, F, Voet, A, Marchand, A, Strelkov, S.V, de Maeyer, M, Chaltin, P, Debyzer, Z. Deposit date: 2010-02-06 Release date: 2010-05-12 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. Nat.Chem.Biol., 6, 2010
3LPT	HIV integrase Descriptor: (6-chloro-2-oxo-4-phenyl-1,2-dihydroquinolin-3-yl)acetic acid, 2-[3-[3-(2-hydroxyethoxy)propoxy]propoxy]ethanol, CALCIUM ION, ... Authors: Nicolet, S, Christ, F, Voet, A, Marchand, A, Strelkov, S.V, de Maeyer, M, Chaltin, P, Debyzer, Z. Deposit date: 2010-02-05 Release date: 2010-05-12 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2 Å) Cite: Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. Nat.Chem.Biol., 6, 2010
2X74	Human foamy virus integrase - catalytic core. Descriptor: INTEGRASE Authors: Rety, S, Delelis, O, Rezabkova, L, Dubanchet, B, Legrand, P, Silhan, J, Lewit-Bentley, A. Deposit date: 2010-02-23 Release date: 2010-08-11 Last modified: 2012-04-18 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Structural Studies of the Catalytic Core of the Primate Foamy Virus (Pfv-1) Integrase Acta Crystallogr.,Sect.F, 66, 2010
2X6S	Human foamy virus integrase - catalytic core. Magnesium-bound structure. Descriptor: INTEGRASE, MAGNESIUM ION Authors: Rety, S, Delelis, O, Rezabkova, L, Dubanchet, B, Silhan, J, Lewit-Bentley, A. Deposit date: 2010-02-19 Release date: 2010-08-11 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Structural Studies of the Catalytic Core of the Primate Foamy Virus (Pfv-1) Integrase Acta Crystallogr.,Sect.F, 66, 2010
2X6N	Human foamy virus integrase - catalytic core. Manganese-bound structure. Descriptor: INTEGRASE, MANGANESE (II) ION Authors: Rety, S, Delelis, O, Rezabkova, L, Dubanchet, B, Silhan, J, Lewit-Bentley, A. Deposit date: 2010-02-18 Release date: 2010-08-11 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Structural Studies of the Catalytic Core of the Primate Foamy Virus (Pfv-1) Integrase Acta Crystallogr.,Sect.F, 66, 2010
2X78	Human foamy virus integrase - catalytic core. Descriptor: INTEGRASE Authors: Rety, S, Delelis, O, Rezabkova, L, Dubanchet, B, Legrand, P, Silhan, J, Lewit-Bentley, A. Deposit date: 2010-02-24 Release date: 2010-08-11 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Studies of the Catalytic Core of the Primate Foamy Virus (Pfv-1) Integrase Acta Crystallogr.,Sect.F, 66, 2010
1A5V	ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3 AND MN CATION Descriptor: 4-ACETYLAMINO-5-HYDROXYNAPHTHALENE-2,7-DISULFONIC ACID, INTEGRASE, MANGANESE (II) ION Authors: Lubkowski, J, Yang, F, Alexandratos, J, Wlodawer, A. Deposit date: 1998-02-18 Release date: 1998-05-27 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor. Proc.Natl.Acad.Sci.USA, 95, 1998
1A5W	ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3 Descriptor: 4-ACETYLAMINO-5-HYDROXYNAPHTHALENE-2,7-DISULFONIC ACID, INTEGRASE Authors: Lubkowski, J, Yang, F, Alexandratos, J, Wlodawer, A. Deposit date: 1998-02-18 Release date: 1998-05-27 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor. Proc.Natl.Acad.Sci.USA, 95, 1998
1A5X	ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3 Descriptor: 4-ACETYLAMINO-5-HYDROXYNAPHTHALENE-2,7-DISULFONIC ACID, INTEGRASE Authors: Lubkowski, J, Yang, F, Alexandratos, J, Wlodawer, A. Deposit date: 1998-02-18 Release date: 1998-05-27 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor. Proc.Natl.Acad.Sci.USA, 95, 1998
1ASV	Avian sarcoma virus integrase catalytic core domain Descriptor: AVIAN SARCOMA VIRUS INTEGRASE Authors: Bujacz, G, Jaskolski, M, Alexandratos, J, Wlodawer, A. Deposit date: 1995-08-25 Release date: 1995-11-14 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.2 Å) Cite: High-resolution structure of the catalytic domain of avian sarcoma virus integrase. J.Mol.Biol., 253, 1995
1ASW	AVIAN SARCOMA VIRUS INTEGRASE CATALYTIC CORE DOMAIN CRYSTALLIZED FROM 20% PEG 4000, 10% ISOPROPANOL, HEPES PH 7.5 USING SELENOMETHIONINE SUBSTITUTED PROTEIN; DATA COLLECTED AT-165 DEGREES C Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AVIAN SARCOMA VIRUS INTEGRASE, ISOPROPYL ALCOHOL Authors: Bujacz, G, Jaskolski, M, Alexandratos, J, Wlodawer, A. Deposit date: 1995-08-25 Release date: 1995-11-14 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: High-resolution structure of the catalytic domain of avian sarcoma virus integrase. J.Mol.Biol., 253, 1995
1B9F	MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY Descriptor: CACODYLATE ION, PROTEIN (INTEGRASE), SULFATE ION Authors: Greenwald, J, Le, V, Butler, S.L, Bushman, F.D, Choe, S. Deposit date: 1999-02-11 Release date: 1999-07-19 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity. Biochemistry, 38, 1999
1BI4	CATALYTIC DOMAIN OF HIV-1 INTEGRASE Descriptor: INTEGRASE Authors: Maignan, S, Guilloteau, J.P, Zhou-Liu, Q, Clement-Mella, C, Mikol, V. Deposit date: 1998-06-22 Release date: 1998-11-04 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases. J.Mol.Biol., 282, 1998
1B92	MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY Descriptor: CACODYLATE ION, PROTEIN (INTEGRASE), SULFATE ION Authors: Greenwald, J, Le, V, Butler, S.L, Bushman, F.D, Choe, S. Deposit date: 1999-02-19 Release date: 1999-07-19 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.02 Å) Cite: The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity. Biochemistry, 38, 1999
1B9D	MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY Descriptor: CACODYLATE ION, PROTEIN (INTEGRASE), SULFATE ION Authors: Greenwald, J, Le, V, Butler, S.L, Bushman, F.D, Choe, S. Deposit date: 1999-02-11 Release date: 1999-07-19 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity. Biochemistry, 38, 1999
1BHL	CACODYLATED CATALYTIC DOMAIN OF HIV-1 INTEGRASE Descriptor: HIV-1 INTEGRASE Authors: Maignan, S, Guilloteau, J.P, Zhou-Liu, Q, Clement-Mella, C, Mikol, V. Deposit date: 1998-06-10 Release date: 1998-10-14 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases. J.Mol.Biol., 282, 1998

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