6XEA
| Crystal Structure of the PTP1B YopH WPD loop Chimera 3 bound to vanadate | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.549 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XEF
| Crystal structure of the PTP1B YopH WPD loop Chimera 4 bound to vanadate | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.048 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XEE
| Crystal Structure of the PTP1B YopH WPD loop Chimera 4 apo form | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XE8
| Crystal Structure of the PTP1B YopH WPD loop Chimera 3 apo form | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.952 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XED
| Crystal Structure of the PTP1B YopH WPD loop Chimera 3 bound to tungstate | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.795 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XEG
| Crystal structure of the PTP1B YopH WPD loop Chimera 4 bound to tungstate | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | Authors: | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | Deposit date: | 2020-06-12 | Release date: | 2021-12-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.549 Å) | Cite: | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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5AWX
| Crystal structure of Human PTPRZ D1 domain | Descriptor: | BROMIDE ION, Receptor-type tyrosine-protein phosphatase zeta | Authors: | Sugawara, H. | Deposit date: | 2015-07-10 | Release date: | 2016-02-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma Sci Rep, 6, 2016
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1AAX
| CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES | Descriptor: | 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN, MAGNESIUM ION, PROTEIN TYROSINE PHOSPHATASE 1B | Authors: | Puius, Y.A, Zhao, Y, Sullivan, M, Lawrence, D, Almo, S.C, Zhang, Z.-Y. | Deposit date: | 1997-01-16 | Release date: | 1998-03-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. Proc.Natl.Acad.Sci.USA, 94, 1997
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1A5Y
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1BZJ
| Human ptp1b complexed with tpicooh | Descriptor: | 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) | Authors: | Groves, M.R, Yao, Z.-J, Barford Jr, D.T.B. | Deposit date: | 1998-10-29 | Release date: | 1999-02-16 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry, 37, 1998
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1BZH
| Cyclic peptide inhibitor of human PTP1B | Descriptor: | PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR), PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B) | Authors: | Groves, M.R, Yao, Z.J, Burke Jr, T.R, Barford, D. | Deposit date: | 1998-10-28 | Release date: | 1999-02-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry, 37, 1998
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1BZC
| HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI | Descriptor: | 4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) | Authors: | Groves, M.R, Yao, Z.J, Jr Burke, T.R, Barford, D. | Deposit date: | 1998-10-27 | Release date: | 1999-02-16 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry, 37, 1998
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1C87
| CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID | Descriptor: | 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) | Authors: | Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P. | Deposit date: | 2000-04-16 | Release date: | 2000-05-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem., 275, 2000
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1C85
| CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-BENZOIC ACID | Descriptor: | 2-(OXALYL-AMINO)-BENZOIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) | Authors: | Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P. | Deposit date: | 2000-04-16 | Release date: | 2000-05-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | 2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases. J.Biol.Chem., 275, 2000
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1C88
| CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID | Descriptor: | 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) | Authors: | Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P. | Deposit date: | 2000-04-16 | Release date: | 2000-05-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem., 275, 2000
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1C83
| CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID | Descriptor: | 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) | Authors: | Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P. | Deposit date: | 2000-04-14 | Release date: | 2000-05-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | 2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases. J.Biol.Chem., 275, 2000
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1C84
| CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXLIC ACID | Descriptor: | 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) | Authors: | Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P. | Deposit date: | 2000-04-14 | Release date: | 2000-05-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | 2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases. J.Biol.Chem., 275, 2000
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1C86
| CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID | Descriptor: | 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) | Authors: | Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P. | Deposit date: | 2000-04-16 | Release date: | 2000-05-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem., 275, 2000
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8CT8
| Crystal structure of Drosophila melanogaster PRL/CBS-pair domain complex | Descriptor: | IODIDE ION, PRL-1 phosphatase, Unextended protein | Authors: | Fakih, R, Goldstein, R.H, Kozlov, G, Gehring, K. | Deposit date: | 2022-05-13 | Release date: | 2023-03-01 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Burst kinetics and CNNM binding are evolutionarily conserved properties of phosphatases of regenerating liver. J.Biol.Chem., 299, 2023
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8DU7
| Room-temperature serial synchrotron crystallography (SSX) structure of apo PTP1B | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Ebrahim, A, Sharma, S, Keedy, D.A. | Deposit date: | 2022-07-27 | Release date: | 2022-08-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Room-temperature serial synchrotron crystallography of the human phosphatase PTP1B. Acta Crystallogr.,Sect.F, 79, 2023
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8EYB
| Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with JAK2 activation loop phosphopeptide | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein kinase JAK2 activation loop phosphopeptide, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Morris, R, Kershaw, N.J, Babon, J.J. | Deposit date: | 2022-10-26 | Release date: | 2023-07-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.349 Å) | Cite: | Structure guided studies of the interaction between PTP1B and JAK. Commun Biol, 6, 2023
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8EXJ
| Crystal structure of PTP1B D181A/Q262A phosphatase domain in complex with a JAK1 activation loop phosphopeptide | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, Tyrosine-protein kinase JAK1 activation loop peptide, ... | Authors: | Morris, R, Kershaw, N.J, Babon, J.J. | Deposit date: | 2022-10-25 | Release date: | 2023-07-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Structure guided studies of the interaction between PTP1B and JAK. Commun Biol, 6, 2023
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8EXI
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8EXM
| Crystal structure of PTP1B D181A/Q262A phosphatase domain with a JAK3 activation loop phosphopeptide | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, Tyrosine-protein kinase JAK3 activation loop peptide, ... | Authors: | Morris, R, Kershaw, N.J, Babon, J.J. | Deposit date: | 2022-10-25 | Release date: | 2023-07-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.349 Å) | Cite: | Structure guided studies of the interaction between PTP1B and JAK. Commun Biol, 6, 2023
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8EXK
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