1C86

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID

Summary for 1C86

• Entry DOI: 10.2210/pdb1c86/pdb
• Related: 1C83 1C84 1C85 1C87 1C88 1ECV
• Descriptor: PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B), 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID (3 entities in total)
• Functional Keywords: hydrolase, phosphorylation, ligand, inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• Total number of polymer chains: 1
• Total formula weight: 34932.77

Authors

Iversen, L.F.,Andersen, H.S.,Mortensen, S.B.,Moller, N.P. (deposition date: 2000-04-16, release date: 2000-05-03, Last modification date: 2023-08-09)

• Primary citation: Iversen, L.F.,Andersen, H.S.,Branner, S.,Mortensen, S.B.,Peters, G.H.,Norris, K.,Olsen, O.H.,Jeppesen, C.B.,Lundt, B.F.,Ripka, W.,Moller, K.B.,Moller, N.P.; Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.; J.Biol.Chem., 275:10300-10307, 2000; PubMed: 10744717; DOI: 10.1074/jbc.275.14.10300

Experimental method

X-RAY DIFFRACTION (2.3 Å)