1BZC

HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI

Summary for 1BZC

Entry DOI	10.2210/pdb1bzc/pdb
Descriptor	PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE), 4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID (3 entities in total)
Functional Keywords	hydrolase(phosphorylation), tyrosine phosphatase, inhibitor complex, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	37795.93
Authors	Groves, M.R.,Yao, Z.J.,Jr Burke, T.R.,Barford, D. (deposition date: 1998-10-27, release date: 1999-02-16, Last modification date: 2023-08-09)
Primary citation	Groves, M.R.,Yao, Z.J.,Roller, P.P.,Burke Jr., T.R.,Barford, D. Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry, 37:17773-17783, 1998 Cited by PubMed: 9922143 DOI: 10.1021/bi9816958 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation