1BZH

Cyclic peptide inhibitor of human PTP1B

Summary for 1BZH

Entry DOI	10.2210/pdb1bzh/pdb
Descriptor	PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B), PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR) (3 entities in total)
Functional Keywords	phosphorylation-inhibitor complex, tyrosine phosphatase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	35725.51
Authors	Groves, M.R.,Yao, Z.J.,Burke Jr., T.R.,Barford, D. (deposition date: 1998-10-28, release date: 1999-02-16, Last modification date: 2023-11-15)
Primary citation	Groves, M.R.,Yao, Z.J.,Roller, P.P.,Burke Jr., T.R.,Barford, D. Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry, 37:17773-17783, 1998 Cited by PubMed: 9922143 DOI: 10.1021/bi9816958 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation