7VQ2
 
 | | Structure of Apo-hsTRPM2 channel TM domain | | 分子名称: | Transient receptor potential cation channel subfamily M member 2 | | 著者 | Yu, X.F, Xie, Y, Zhang, X.K, Ma, C, Guo, J.T, Yang, F, Yang, W. | | 登録日 | 2021-10-18 | | 公開日 | 2021-12-22 | | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | | 主引用文献 | Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel.
Cell Rep, 37, 2021
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7WLI
 | | CryoEM structure of human low-voltage activated T-type calcium channel CaV3.3 (apo) | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y. | | 登録日 | 2022-01-13 | | 公開日 | 2022-05-04 | | 最終更新日 | 2022-05-25 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure, gating, and pharmacology of human Ca V 3.3 channel.
Nat Commun, 13, 2022
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7WLK
 | | CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with Otilonium Bromide(OB) | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-[diethyl(methyl)-$l^{4}-azanyl]ethyl 4-[(2-octoxyphenyl)carbonylamino]benzoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y. | | 登録日 | 2022-01-13 | | 公開日 | 2022-05-04 | | 最終更新日 | 2022-05-25 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure, gating, and pharmacology of human Ca V 3.3 channel.
Nat Commun, 13, 2022
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7WLJ
 | | CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with mibefradil (MIB) | | 分子名称: | (1S,2S)-2-(2-{[3-(1H-benzimidazol-2-yl)propyl](methyl)amino}ethyl)-6-fluoro-1-(propan-2-yl)-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y. | | 登録日 | 2022-01-13 | | 公開日 | 2022-05-04 | | 最終更新日 | 2022-05-25 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structure, gating, and pharmacology of human Ca V 3.3 channel.
Nat Commun, 13, 2022
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7WLL
 | | CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with pimozide(PMZ) | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1~{H}-benzimidazol-2-one, ... | | 著者 | He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y. | | 登録日 | 2022-01-13 | | 公開日 | 2022-05-04 | | 最終更新日 | 2022-05-25 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure, gating, and pharmacology of human Ca V 3.3 channel.
Nat Commun, 13, 2022
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6WKN
 | | PL-bound rat TRPV2 in nanodiscs | | 分子名称: | Transient receptor potential cation channel subfamily V member 2, piperlongumine | | 著者 | Pumroy, R.P, Moiseenkova-Bell, V.Y. | | 登録日 | 2020-04-16 | | 公開日 | 2021-04-21 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | | 主引用文献 | Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression.
Acs Cent.Sci., 7, 2021
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8BDC
 | | Human apo TRPM8 in a closed state (composite map) | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ... | | 著者 | Palchevskyi, S, Czarnocki-Cieciura, M, Vistoli, G, Gervasoni, S, Nowak, E, Beccari, A.R, Nowotny, M, Talarico, C. | | 登録日 | 2022-10-19 | | 公開日 | 2023-11-01 | | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | | 主引用文献 | Structure of human TRPM8 channel.
Commun Biol, 6, 2023
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5AN8
 | | Cryo-electron microscopy structure of rabbit TRPV2 ion channel | | 分子名称: | TRPV2 | | 著者 | Zubcevic, L, Herzik, M.A.J, Chung, B.C, Lander, G.C, Lee, S.Y. | | 登録日 | 2015-09-04 | | 公開日 | 2015-12-23 | | 最終更新日 | 2019-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cryo-Electron Microscopy of the Trpv2 Ion Channel
Nat.Struct.Mol.Biol., 23, 2016
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1ORQ
 | | X-ray structure of a voltage-dependent potassium channel in complex with an Fab | | 分子名称: | 6E1 Fab heavy chain, 6E1 Fab light chain, CADMIUM ION, ... | | 著者 | Jiang, Y, Lee, A, Chen, J, Ruta, V, Cadene, M, Chait, B.T, MacKinnon, R. | | 登録日 | 2003-03-14 | | 公開日 | 2003-05-06 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | X-ray structure of a voltage-dependent K+ channel
Nature, 423, 2003
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3WKV
 | | Voltage-gated proton channel: VSOP/Hv1 chimeric channel | | 分子名称: | Ion channel | | 著者 | Takeshita, K, Sakata, S, Yamashita, E, Fujiwara, Y, Kawanabe, A, Kurokawa, T, Okochi, Y, Matsuda, M, Narita, H, Okamura, Y, Nakagawa, A. | | 登録日 | 2013-10-31 | | 公開日 | 2014-03-05 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.453 Å) | | 主引用文献 | X-ray crystal structure of voltage-gated proton channel.
Nat.Struct.Mol.Biol., 21, 2014
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1ORS
 | | X-ray structure of the KvAP potassium channel voltage sensor in complex with an Fab | | 分子名称: | 33H1 Fab heavy chain, 33H1 Fab light chain, potassium channel | | 著者 | Jiang, Y, Lee, A, Chen, J, Ruta, V, Cadene, M, Chait, B.T, MacKinnon, R. | | 登録日 | 2003-03-14 | | 公開日 | 2003-05-06 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | X-ray structure of a voltage-dependent K+ channel
Nature, 423, 2003
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8IJK
 | | human KCNQ2-CaM-Ebio1 complex in the presence of PIP2 | | 分子名称: | Calmodulin-1, N-(1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2 | | 著者 | Ma, D, Guo, J. | | 登録日 | 2023-02-27 | | 公開日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | A small-molecule activation mechanism that directly opens the KCNQ2 channel.
Nat.Chem.Biol., 2024
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6FG3
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6FOO
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3JAV
 | | Structure of full-length IP3R1 channel in the apo-state determined by single particle cryo-EM | | 分子名称: | Inositol 1,4,5-trisphosphate receptor type 1 | | 著者 | Fan, G, Baker, M.L, Wang, Z, Baker, M.R, Sinyagovskiy, P.A, Chiu, W, Ludtke, S.J, Serysheva, I.I. | | 登録日 | 2015-06-30 | | 公開日 | 2015-10-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Gating machinery of InsP3R channels revealed by electron cryomicroscopy.
Nature, 527, 2015
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6U84
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6U86
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6U8A
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7A6U
 | | Cryo-EM structure of the cytoplasmic domain of human TRPC6 | | 分子名称: | Short transient receptor potential channel 6, UNKNOWN ATOM OR ION | | 著者 | Grieben, M, Pike, A.C.W, Wang, D, Mukhopadhyay, S.M.M, Chalk, R, Marsden, B.D, Burgess-Brown, N.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | | 登録日 | 2020-08-26 | | 公開日 | 2020-09-30 | | 最終更新日 | 2021-07-07 | | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | | 主引用文献 | Cryo-EM structure of the cytoplasmic domain of human TRPC6
TO BE PUBLISHED
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7BYM
 | | Cryo-EM structure of human KCNQ4 with retigabine | | 分子名称: | Calmodulin-3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4, POTASSIUM ION, ... | | 著者 | Shen, H, Li, T, Yue, Z. | | 登録日 | 2020-04-23 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
Mol.Cell, 81, 2021
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7BYL
 | | Cryo-EM structure of human KCNQ4 | | 分子名称: | Calmodulin-3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4, POTASSIUM ION, ... | | 著者 | Shen, H, Li, T, Yue, Z. | | 登録日 | 2020-04-23 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
Mol.Cell, 81, 2021
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7BYN
 | | Cryo-EM structure of human KCNQ4 with linopirdine | | 分子名称: | 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one, Calmodulin-3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 4, ... | | 著者 | Shen, H, Li, T, Yue, Z. | | 登録日 | 2020-04-23 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
Mol.Cell, 81, 2021
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7SIP
 | | Structure of shaker-IR | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel protein Shaker | | 著者 | Tan, X, Bae, C, Stix, R, Fernandez, A.I, Huffer, K, Chang, T, Jiang, J, Faraldo-Gomez, J.D, Swartz, K.J. | | 登録日 | 2021-10-14 | | 公開日 | 2022-03-30 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure of the Shaker Kv channel and mechanism of slow C-type inactivation.
Sci Adv, 8, 2022
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7SJ1
 | | Structure of shaker-W434F | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel protein Shaker | | 著者 | Tan, X, Bae, C, Stix, R, Fernandez, A.I, Huffer, K, Chang, T, Jiang, J, Faraldo-Gomez, J.D, Swartz, K.J. | | 登録日 | 2021-10-15 | | 公開日 | 2022-03-30 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structure of the Shaker Kv channel and mechanism of slow C-type inactivation.
Sci Adv, 8, 2022
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5XSY
 | | Structure of the Nav1.4-beta1 complex from electric eel | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein, Voltage-gated sodium channel beta subunit 1, ... | | 著者 | Yan, Z, Zhou, Q, Wu, J.P, Yan, N. | | 登録日 | 2017-06-15 | | 公開日 | 2017-08-09 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structure of the Nav1.4-beta 1 Complex from Electric Eel.
Cell, 170, 2017
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