PDB: 301 件ウェブページステータス検索Chemie searchBIRD

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8DOW	Cryo-EM structure of HIV-1 Env(CH848 10.17 DS.SOSIP_DT) in complex with DH1030.1 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1030.1 Fab Heavy chain, ... 著者 Gobeil, S, Acharya, P. 登録日 2022-07-14 公開日 2023-07-19 実験手法 ELECTRON MICROSCOPY (3.69 Å) 主引用文献 Shared recognition mechanism for HIV-1 envelope-reactive V3 glycan broadly neutralizing B cell lineage maturation in humans and macaques To Be Published
8EU8	Cryo-EM structure of CH848 10.17DT DS-SOSIP-2P Env 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH848 10.17DT SOSIP Envelope glycoprotein gp160 著者 Wrapp, D, Acharya, P, Haynes, B.F. 登録日 2022-10-18 公開日 2023-01-04 最終更新日 2023-02-08 実験手法 ELECTRON MICROSCOPY (3.73 Å) 主引用文献 Structure-Based Stabilization of SOSIP Env Enhances Recombinant Ectodomain Durability and Yield. J.Virol., 97, 2023
8FAD	Asymmetric structure of cleaved HIV-1 AD8 envelope glycoprotein trimer in styrene-maleic acid lipid nanoparticles 分子名称: 1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Wang, K, Zhang, S, Sodroski, J, Mao, Y. 登録日 2022-11-26 公開日 2023-06-07 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Asymmetric conformations of cleaved HIV-1 envelope glycoprotein trimers in styrene-maleic acid lipid nanoparticles. Commun Biol, 6, 2023
8FAE	Asymmetric structure of cleaved HIV-1 AE2 envelope glycoprotein trimer in styrene-maleic acid lipid nanoparticles (AE2.1) 分子名称: 1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Wang, K, Zhang, S, Sodroski, J, Mao, Y. 登録日 2022-11-26 公開日 2023-06-07 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Asymmetric conformations of cleaved HIV-1 envelope glycoprotein trimers in styrene-maleic acid lipid nanoparticles. Commun Biol, 6, 2023
7SQ1	BG505.MD39TS Env trimer in complex with Fab from antibody C05 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C05 Fab Light chain, ... 著者 Moore, A, Du, J, Xu, Z, Walker, S, Kulp, D.W, Pallesen, J. 登録日 2021-11-04 公開日 2022-06-22 最終更新日 2022-12-07 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer. Nat Commun, 13, 2022
7T2P	The Envelope Glycoprotein SIVmac239.K180S SOSIP trimer in complex with 3 copies of the neutralizing antibody K11 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Berndsen, Z.T, Ward, A.B. 登録日 2021-12-06 公開日 2022-10-19 最終更新日 2023-07-05 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus. Nat Commun, 13, 2022
7T4G	The Envelope Glycoprotein SIVmac239.K180S SOSIP trimer in complex with 3 copies of the neutralizing antibody K11 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Berndsen, Z.T, Ward, A.B. 登録日 2021-12-09 公開日 2022-10-19 最終更新日 2023-07-05 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus. Nat Commun, 13, 2022
7TCN	Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.SOSIP.664 with high-mannose glycans 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH235.12 Fab Heavy Chain, ... 著者 Manne, K, Henderson, R, Acharya, P. 登録日 2021-12-27 公開日 2023-08-02 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.G458Y.SOSIP.664 To Be Published
7TCO	Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.G458Y.SOSIP.664 with high-mannose glycans 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH235.12 Fab Heavy Chain, ... 著者 Manne, K, Henderson, R, Acharya, P. 登録日 2021-12-27 公開日 2023-08-02 実験手法 ELECTRON MICROSCOPY (4.19 Å) 主引用文献 Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.G458Y.SOSIP.664 To Be Published
7T9T	Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.SOSIP.664 with complex glycans 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Manne, K, Acharya, P. 登録日 2021-12-20 公開日 2023-08-16 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Cryo-EM structure of CH235.12 in complex with HIV-1 Env trimer CH505TF.N279K.G458Y.SOSIP.664 To Be Published
7TXD	Cryo-EM structure of BG505 SOSIP HIV-1 Env trimer in complex with CD4 receptor (D1D2) and broadly neutralizing darpin bnD.9 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Broadly neutralizing darpin bnd.9, ... 著者 Cerutti, G, Gorman, J, Kwong, P.D, Shapiro, L. 登録日 2022-02-08 公開日 2023-04-12 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (3.87 Å) 主引用文献 Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization. Nat.Struct.Mol.Biol., 30, 2023
7UCG	Structure of the DU422 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24 分子名称: 10-1074 Fab heavy chain, 10-1074 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Barnes, C.O, Bjorkman, P.J. 登録日 2022-03-16 公開日 2022-08-17 最終更新日 2022-09-07 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 A naturally arising broad and potent CD4-binding site antibody with low somatic mutation. Sci Adv, 8, 2022
7UCF	Structure of the BG505 SOSIP.664 trimer in complex with neutralizing antibody Fab fragments 10-1074 and BG24 分子名称: 10-1074 Fab heavy chain, 10-1074 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Barnes, C.O, Bjorkman, P.J. 登録日 2022-03-16 公開日 2022-08-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 A naturally arising broad and potent CD4-binding site antibody with low somatic mutation. Sci Adv, 8, 2022
7UGP	Cryo-EM structure of BG24 Fabs with an inferred germline light chain and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 containing the N276 gp120 glycan- Class 1 分子名称: 10-1074 Fab heavy chain, 10-1074 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Dam, K.A, Bjorkman, P.J. 登録日 2022-03-25 公開日 2022-11-09 最終更新日 2022-11-16 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design. Nat Commun, 13, 2022
7UGO	Cryo-EM structure of BG24 inferred germline Fabs with mature CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 分子名称: 10-1074 Fab heavy chain, 10-1074 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Dam, K.A, Bjorkman, P.J. 登録日 2022-03-25 公開日 2022-10-26 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design. Nat Commun, 13, 2022
7UGN	Cryo-EM structure of BG24 inferred germline Fabs with germline CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 - Class 1 分子名称: 10-1074 Fab heavy chain, 10-1074 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Dam, K.A, Bjorkman, P.J. 登録日 2022-03-25 公開日 2022-10-26 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design. Nat Commun, 13, 2022
5THR	Cryo-EM structure of a BG505 Env-sCD4-17b-8ANC195 complex 分子名称: 17b Fab VH domain, 17b Fab VL domain, 8ANC195 G52K5 VH domain, ... 著者 Wang, H, Bjorkman, P.J. 登録日 2016-09-30 公開日 2016-11-16 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (8.9 Å) 主引用文献 Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop. Proc.Natl.Acad.Sci.USA, 113, 2016
5T3X	3.9 Angstrom Crystal Structure of a Fully and Natively Glycosylated BG505 SOSIP.664 HIV-1 Env Trimer in Complex with the Broadly Neutralizing Antibodies IOMA and 10-1074. 分子名称: 10-1074 Heavy Chain, 10-1074 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Gristick, H.B, Bjorkman, P.J. 登録日 2016-08-26 公開日 2016-10-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site. Nat.Struct.Mol.Biol., 23, 2016
5UTF	Crystal Structure of a Stabilized DS-SOSIP.6mut BG505 gp140 HIV-1 Env Trimer, Containing Mutations I201C-P433C (DS), L154M, Y177W, N300M, N302M, T320L, I420M in Complex with Human Antibodies PGT122 and 35O22 at 4.3 A 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35022 Heavy chain, ... 著者 Pancera, M, Chuang, G.-Y, Xu, K, Kwong, P.D. 登録日 2017-02-14 公開日 2017-03-29 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.503 Å) 主引用文献 Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity. J. Virol., 91, 2017
5VN8	Cryo-EM model of B41 SOSIP.664 in complex with fragment antigen binding variable domain of b12 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... 著者 Ozorowski, G, Pallesen, J, Ward, A.B, Cottrell, C.A. 登録日 2017-04-28 公開日 2017-07-12 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike. Nature, 547, 2017
6CDI	Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, ... 著者 Acharya, P, Xu, K, Liu, K, Carragher, B, Potter, C.S, Kwong, P.D. 登録日 2018-02-08 公開日 2018-05-16 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018
6CE0	Crystal structure of a HIV-1 clade B tier-3 isolate H078.14 UFO-BG Env trimer in complex with broadly neutralizing Fabs PGT124 and 35O22 at 4.6 Angstrom 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Heavy chain, ... 著者 Kumar, S, Sarkar, A, Wilson, I.A. 登録日 2018-02-09 公開日 2018-12-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.602 Å) 主引用文献 HIV-1 vaccine design through minimizing envelope metastability. Sci Adv, 4, 2018
6CH7	XFEL crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and 35O22 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Barnes, C.O, Bjorkman, P.J. 登録日 2018-02-22 公開日 2018-05-02 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope. Nat Commun, 9, 2018
5U7O	Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-626529 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 Angstrom 分子名称: 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Pancera, M, Lai, Y.-T, Kwong, P.D. 登録日 2016-12-12 公開日 2017-08-30 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.031 Å) 主引用文献 Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529. Nat. Chem. Biol., 13, 2017
6CH8	Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and 35O22 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Heavy Chain, 35O22 Light Chain, ... 著者 Barnes, C.O, Bjorkman, P.J. 登録日 2018-02-22 公開日 2018-05-02 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.1 Å) 主引用文献 Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope. Nat Commun, 9, 2018

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