8JKM
| RN-1747 bound state of mTRPV4 | 分子名称: | Transient receptor potential cation channel subfamily V member 4 | 著者 | Zhen, W.X, Yang, F. | 登録日 | 2023-06-01 | 公開日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | 主引用文献 | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
|
|
7RAU
| |
8JVI
| Structure of human TRPV4 with antagonist A2 | 分子名称: | Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | 著者 | Fan, J, Lei, X. | 登録日 | 2023-06-28 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 2024
|
|
7RAS
| |
8JVJ
| Structure of human TRPV4 with antagonist A2 and RhoA | 分子名称: | Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | 著者 | Fan, J, Lei, X. | 登録日 | 2023-06-28 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 2024
|
|
8JU5
| Structure of human TRPV4 with antagonist A1 | 分子名称: | 4-[(3~{S},4~{S})-4-(aminomethyl)-1-(5-chloranylpyridin-2-yl)sulfonyl-4-oxidanyl-pyrrolidin-3-yl]oxy-2-fluoranyl-benzenecarbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | 著者 | Fan, J, Lei, X. | 登録日 | 2023-06-24 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 2024
|
|
8JU6
| Structure of human TRPV4 with antagonist GSK279 | 分子名称: | 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | 著者 | Fan, J, Lei, X. | 登録日 | 2023-06-24 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 2024
|
|
7RQU
| Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in a closed state, class I | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, SODIUM ION, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
|
|
7RQZ
| Cryo-EM structure of the full-length TRPV1 with RTx at 48 degrees Celsius, in an open state, class alpha | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
|
|
7RQV
| Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an intermediate-closed state, class II | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
|
|
7RQW
| Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an open state, class III | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
|
|
7RQX
| Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an intermediate-open state, class A | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
|
|
7RQY
| Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an open state, class B | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
|
|
7RHI
| Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openII state | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-17 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
|
|
7RHJ
| Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-blocked open state | 分子名称: | (2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, ... | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-17 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
|
|
7RHG
| Cryo-EM structure of human rod CNGA1/B1 channel in cAMP-bound state | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-17 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
|
|
7RHK
| Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-trapped closed state | 分子名称: | (2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, ... | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-17 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
|
|
7RHH
| Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openI state | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-17 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
|
|
7RHL
| Cryo-EM structure of human rod Apo CNGA1/B1 channel with CLZ coiled coil | 分子名称: | Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-17 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
|
|
7RH9
| Cryo-EM structure of human rod CNGA1/B1 channel in apo state | 分子名称: | Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-16 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
|
|
7S8C
| Cryo-EM structure of human TRPV6 in complex with inhibitor econazole | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, CALCIUM ION, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2021-09-17 | 公開日 | 2021-11-17 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. Nat Commun, 12, 2021
|
|
7S8B
| Cryo-EM structure of human TRPV6 in complex with channel blocker ruthenium red | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2021-09-17 | 公開日 | 2021-11-17 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | 主引用文献 | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. Nat Commun, 12, 2021
|
|
7S89
| Open apo-state cryo-EM structure of human TRPV6 in cNW11 nanodiscs | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2021-09-17 | 公開日 | 2021-11-17 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | 主引用文献 | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. Nat Commun, 12, 2021
|
|
7RHS
| Cryo-EM structure of apo-state of human CNGA3/CNGB3 channel | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cyclic nucleotide-gated cation channel alpha-3, Cyclic nucleotide-gated cation channel beta-3, ... | 著者 | Zheng, X, Yang, J. | 登録日 | 2021-07-18 | 公開日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | Structure of the human cone photoreceptor cyclic nucleotide-gated channel. Nat.Struct.Mol.Biol., 29, 2022
|
|
7S88
| Open apo-state cryo-EM structure of human TRPV6 in glyco-diosgenin detergent | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2021-09-17 | 公開日 | 2021-11-17 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | 主引用文献 | Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. Nat Commun, 12, 2021
|
|