7S8B

Cryo-EM structure of human TRPV6 in complex with channel blocker ruthenium red

Summary for 7S8B

• Entry DOI: 10.2210/pdb7s8b/pdb
• Related: 7S88 7S89
• EMDB information: 24890 24891 24892
• Descriptor: Transient receptor potential cation channel subfamily V member 6, CHOLESTEROL HEMISUCCINATE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (6 entities in total)
• Functional Keywords: transient receptor potential v family member 6, trp, channel, ruthenium red, channel blocker, antagonist, cnw11, nanodiscs, trpv6, membrane protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 344556.24

Authors

Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (deposition date: 2021-09-17, release date: 2021-11-17)

• Primary citation: Neuberger, A.,Nadezhdin, K.D.,Sobolevsky, A.I.; Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole.; Nat Commun, 12:6284-6284, 2021; PubMed: 34725357; DOI: 10.1038/s41467-021-26608-x

Experimental method

ELECTRON MICROSCOPY (2.43 Å)