PDB: 1012 件ウェブページステータス検索Chemie searchBIRD

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5EOE	Crystal structure of extended-spectrum beta-lactamase BEL-1 (orthorhombic form) 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, Beta-lactamase, ... 著者 Pozzi, C, De Luca, F, Benvenuti, M, Docquier, J.D, Mangani, S. 登録日 2015-11-10 公開日 2016-09-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum beta-Lactamase and Its Complexes with Moxalactam and Imipenem. Antimicrob.Agents Chemother., 60, 2016
5EOO	Crystal structure of extended-spectrum beta-lactamase BEL-1 (monoclinic form) 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, Beta-lactamase, CHLORIDE ION, ... 著者 Pozzi, C, De Luca, F, Benvenuti, M, Docquier, J.D, Mangani, S. 登録日 2015-11-10 公開日 2016-09-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum beta-Lactamase and Its Complexes with Moxalactam and Imipenem. Antimicrob.Agents Chemother., 60, 2016
5EEC	Crystal structure of KPC-2 beta-lactamase in complex with the S02030 boronic acid inhibitor 分子名称: 1-{(2R)-2-(dihydroxyboranyl)-2-[(thiophen-2-ylacetyl)amino]ethyl}-1H-1,2,3-triazole-4-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, SULFATE ION 著者 Nguyen, N.Q, van den Akker, F. 登録日 2015-10-22 公開日 2016-02-03 最終更新日 2016-03-09 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Crystal Structures of KPC-2 and SHV-1 beta-Lactamases in Complex with the Boronic Acid Transition State Analog S02030. Antimicrob.Agents Chemother., 60, 2016
5E2E	Crystal Structure of Beta-lactamase Precursor BlaA from Yersinia enterocolitica 分子名称: Beta-lactamase 著者 Kim, Y, Joachimiak, G, Endres, M, Babnigg, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2015-10-01 公開日 2015-10-28 最終更新日 2022-04-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structure of Beta-lactamase Precursor BlaA from Yersinia enterocolitica To Be Published
5EUA	Crystal structure of extended-spectrum beta-lactamase BEL-1 in complex with Moxalactam 分子名称: (2R)-2-[(1R)-1-{[(2R)-2-carboxy-2-(4-hydroxyphenyl)acetyl]amino}-1-methoxy-2-oxoethyl]-5-methylidene-5,6-dihydro-2H-1,3 -oxazine-4-carboxylic acid, Beta-lactamase, SODIUM ION 著者 Pozzi, C, De Luca, F, Benvenuti, M, Docquier, J.D, Mangani, S. 登録日 2015-11-18 公開日 2016-09-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum beta-Lactamase and Its Complexes with Moxalactam and Imipenem. Antimicrob.Agents Chemother., 60, 2016
8G2R	CRYSTAL STRUCTURE OF THE KPC-2 D179N VARIANT IN COMPLEX WITH AVIBACTAM 分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Carbapenem-hydrolyzing beta-lactamase KPC 著者 Alsenani, T, van den Akker, F. 登録日 2023-02-06 公開日 2023-08-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Exploring avibactam and relebactam inhibition of Klebsiella pneumoniae carbapenemase D179N variant: role of the Omega loop-held deacylation water. Antimicrob.Agents Chemother., 67, 2023
8G2T	CRYSTAL STRUCTURE OF THE KPC-2 D179N VARIANT IN COMPLEX WITH RELEBACTAM (IMINE HYDROLYSIS INTERMEDIATE) 分子名称: (2S,5R)-5-amino-1-formyl-5-hydroxy-N-(piperidin-4-yl)piperidine-2-carboxamide, Carbapenem-hydrolyzing beta-lactamase KPC, PHOSPHATE ION 著者 Alsenani, T, van den Akker, F. 登録日 2023-02-06 公開日 2023-08-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Exploring avibactam and relebactam inhibition of Klebsiella pneumoniae carbapenemase D179N variant: role of the Omega loop-held deacylation water. Antimicrob.Agents Chemother., 67, 2023
5FAP	CTX-M-15 in complex with FPI-1602 分子名称: Beta-lactamase, [[(3~{R},6~{S})-6-[(azetidin-3-ylcarbonylamino)carbamoyl]-1-methanoyl-piperidin-3-yl]amino] hydrogen sulfate 著者 King, A.M, King, D.T, French, S, Brouillette, E, Asli, A, Alexander, A.N, Vuckovic, M, Maiti, S.N, Parr, T.R, Brown, E.D, Malouin, F, Strynadka, N.C.J, Wright, G.D. 登録日 2015-12-11 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-beta-Lactamases and Penicillin-Binding Proteins. Acs Chem.Biol., 11, 2016
5FA7	CTX-M-15 in complex with FPI-1523 分子名称: Beta-lactamase, [[(3~{R},6~{S})-6-(acetamidocarbamoyl)-1-methanoyl-piperidin-3-yl]amino] hydrogen sulfate 著者 King, A.M, King, D.T, French, S, Brouillette, E, Asli, A, Alexander, A.N, Vuckovic, M, Maiti, S.N, Parr, T.R, Brown, E.D, Malouin, F, Strynadka, N.C.J, Wright, G.D. 登録日 2015-12-11 公開日 2016-01-20 最終更新日 2019-11-20 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-beta-Lactamases and Penicillin-Binding Proteins. Acs Chem.Biol., 11, 2016
5GLC	Crystal structure of the class A beta-lactamase PenL-tTR11 containing 20 residues insertion in omega-loop 分子名称: Beta-lactamase 著者 Choi, J.M, Yi, H, Kim, H.S, Lee, S.H. 登録日 2016-07-10 公開日 2017-02-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.601 Å) 主引用文献 High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A beta-lactamase, PenL Sci Rep, 6, 2016
5GLD	Crystal structure of the class A beta-lactamase PenL-tTR11 in complex with CBA 分子名称: Beta-lactamase, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE 著者 Choi, J.M, Yi, H, Kim, H.S, Lee, S.H. 登録日 2016-07-10 公開日 2017-02-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A beta-lactamase, PenL Sci Rep, 6, 2016
3TSG	Crystal structure of GES-14 分子名称: Extended-spectrum beta-lactamase GES-14, GLYCEROL, IODIDE ION 著者 Delbruck, H, Hoffmann, K.M.V, Bebrone, C. 登録日 2011-09-13 公開日 2012-09-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Kinetic and crystallographic studies of extended-spectrum GES-11, GES-12, and GES-14 beta-lactamases. Antimicrob.Agents Chemother., 56, 2012
5GL9	Crystal structure of the class A beta-lactamase PenL 分子名称: Beta-lactamase, GLYCEROL 著者 Choi, J.M, Yi, H, Kim, H.S, Lee, S.H. 登録日 2016-07-10 公開日 2017-02-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A beta-lactamase, PenL Sci Rep, 6, 2016
5GLA	Crystal structure of the class A beta-lactamase PenL-tTR10 containing 10 residues insertion in omega-loop 分子名称: Beta-lactamase 著者 Choi, J.M, Yi, H, Kim, H.S, Lee, S.H. 登録日 2016-07-10 公開日 2017-02-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A beta-lactamase, PenL Sci Rep, 6, 2016
3TOI	Tailoring Enzyme Stability and Exploiting Stability-Trait Linkage by Iterative Truncation and Optimization 分子名称: Ampicillin resistance protein 著者 Tam, H.K, Einsle, O. 登録日 2011-09-05 公開日 2012-05-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Exploring the Molecular Linkage of Protein Stability Traits for Enzyme Optimization by Iterative Truncation and Evolution. Biochemistry, 51, 2012
5GLB	Crystal structure of the class A beta-lactamase PenL-tTR10 in complex with CBA 分子名称: Beta-lactamase, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE 著者 Choi, J.M, Yi, H, Kim, H.S, Lee, S.H. 登録日 2016-07-10 公開日 2017-02-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 High adaptability of the omega loop underlies the substrate-spectrum-extension evolution of a class A beta-lactamase, PenL Sci Rep, 6, 2016
5HW3	Crystal structure of a beta lactamase from Burkholderia vietnamiensis 分子名称: ACETATE ION, Beta-lactamase, SULFATE ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-01-29 公開日 2016-02-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Crystal structure of a beta lactamase from Burkholderia vietnamiensis to be published
5HW5	Crystal structure of TEM1 beta-lactamase in the presence of 2.0 MPa xenon 分子名称: Beta-lactamase TEM, XENON 著者 Roose, B.W, Dmochowski, I.J. 登録日 2016-01-28 公開日 2017-06-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Structure of TEM1 beta-lactamase To Be Published
5HX9	Crystal structure of Beta-lactamase from Burkholderia vietnamiensis 分子名称: 1,2-ETHANEDIOL, Beta-lactamase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-01-29 公開日 2016-02-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of Beta-lactamase from Burkholderia vietnamiensis to be published
5HVI	Crystal structure of TEM1 beta-lactamase 分子名称: Beta-lactamase TEM 著者 Roose, B.W, Dmochowski, I.J. 登録日 2016-01-28 公開日 2017-06-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 A Structural Basis for129Xe Hyper-CEST Signal in TEM-1 beta-Lactamase. Chemphyschem, 2018
5HW1	Crystal structure of TEM1 beta-lactamase in the presence of 1.2 MPa xenon 分子名称: Beta-lactamase TEM, XENON 著者 Roose, B.W, Dmochowski, I.J. 登録日 2016-01-28 公開日 2017-06-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 A Structural Basis for129Xe Hyper-CEST Signal in TEM-1 beta-Lactamase. Chemphyschem, 2018
5IHV	Crystal structure of a beta-lactamase from Burkholderia ambifaria 分子名称: 1,2-ETHANEDIOL, Beta-lactamase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-02-29 公開日 2016-03-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Crystal structure of a beta-lactamase from Burkholderia ambifaria to be published
3V5M	Crystal structure of M69V mutant of SHV beta-lactamase 分子名称: Beta-lactamase, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE 著者 van den Akker, F, Rodkey, E.A. 登録日 2011-12-16 公開日 2012-08-08 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 The importance of the trans-enamine intermediate as a beta-lactamase inhibition strategy probed in inhibitor-resistant SHV beta-lactamase variants. Chemmedchem, 7, 2012
3VFH	BlaC E166A CDC-1 Acyl-Intermediate 分子名称: (2R)-5-methylidene-2-{(1R)-2-oxo-1-[(phenylacetyl)amino]ethyl}-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION 著者 Mire, J.A, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2012-01-09 公開日 2012-09-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 BlaC-Specific Fluorogenic Probes for Rapid Tuberculosis Detection To be Published
3V3S	Crystal structure of GES-18 分子名称: Extended spectrum beta-lactamase GES-18 著者 Delbruck, H, Hoffmann, K.M.V, Bebrone, C. 登録日 2011-12-14 公開日 2012-11-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 GES-18, a new carbapenem-hydrolyzing GES-Type beta-lactamase from pseudomonas aeruginosa that contains Ile80 and Ser170 residues. Antimicrob.Agents Chemother., 57, 2013

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