3V5M

Crystal structure of M69V mutant of SHV beta-lactamase

Summary for 3V5M

• Entry DOI: 10.2210/pdb3v5m/pdb
• Related: 2H10
• Descriptor: Beta-lactamase, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE (3 entities in total)
• Functional Keywords: class a beta-lactamase fold, hydrolyze b-lactam antibiotics, hydrolase
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 29892.16

Authors

van den Akker, F.,Rodkey, E.A. (deposition date: 2011-12-16, release date: 2012-08-08)

• Primary citation: Ke, W.,Rodkey, E.A.,Sampson, J.M.,Skalweit, M.J.,Sheri, A.,Pagadala, S.R.,Nottingham, M.D.,Buynak, J.D.,Bonomo, R.A.,van den Akker, F.; The importance of the trans-enamine intermediate as a beta-lactamase inhibition strategy probed in inhibitor-resistant SHV beta-lactamase variants.; Chemmedchem, 7:1002-1008, 2012; PubMed: 22438274; DOI: 10.1002/cmdc.201200006

Experimental method

X-RAY DIFFRACTION (1.3 Å)