PDB: 674 件ウェブページステータス検索Chemie searchBIRD

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3WKC	Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 分子名称: 4-{2,5-dimethyl-1-[(2R)-tetrahydrofuran-2-ylmethyl]-1H-pyrrol-3-yl}-1,3-thiazol-2-amine, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... 著者 Amano, Y, Yamaguchi, T, Tanabe, E. 登録日 2013-10-18 公開日 2014-04-16 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
3WK6	Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 分子名称: (5R)-5-methyl-N-(2-phenylethyl)-4,5-dihydro-1,3-thiazol-2-amine, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... 著者 Amano, Y, Yamaguchi, T, Tanabe, E. 登録日 2013-10-17 公開日 2014-04-16 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
3WK4	Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 分子名称: 1-[(1R)-1-cyclopropylethyl]-3-phenylurea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... 著者 Amano, Y, Yamaguchi, T, Tanabe, E. 登録日 2013-10-17 公開日 2014-04-16 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
3WK7	Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 分子名称: 2-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazole, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... 著者 Amano, Y, Yamaguchi, T, Tanabe, E. 登録日 2013-10-17 公開日 2014-04-16 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
3WKA	Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 分子名称: 6-amino-1-methyl-5-(piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... 著者 Amano, Y, Yamaguchi, T, Tanabe, E. 登録日 2013-10-18 公開日 2014-04-16 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
3WKB	Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 分子名称: 4-benzyl-3,4-dihydroquinoxalin-2(1H)-one, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... 著者 Amano, Y, Yamaguchi, T, Tanabe, E. 登録日 2013-10-18 公開日 2014-04-16 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
3WKE	Crystal structure of soluble epoxide hydrolase in complex with t-AUCB 分子名称: 4-[(trans-4-{[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-ylcarbamoyl]amino}cyclohexyl)oxy]benzoic acid, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... 著者 Amano, Y, Yamaguchi, T, Tanabe, E. 登録日 2013-10-18 公開日 2014-04-16 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
3WK8	Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 分子名称: 6-(trifluoromethyl)-1,3-benzothiazol-2-amine, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... 著者 Amano, Y, Yamaguchi, T, Tanabe, E. 登録日 2013-10-17 公開日 2014-04-16 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
3WK5	Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 分子名称: 2-cyclopentyl-N-(1,3-thiazol-2-yl)acetamide, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... 著者 Amano, Y, Yamaguchi, T, Tanabe, E. 登録日 2013-10-17 公開日 2014-04-16 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
3WK9	Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor 分子名称: 5-(4-bromobenzyl)-1,3-thiazol-2-amine, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... 著者 Amano, Y, Yamaguchi, T, Tanabe, E. 登録日 2013-10-18 公開日 2014-04-16 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography. Bioorg.Med.Chem., 22, 2014
5ALO	ligand complex structure of soluble epoxide hydrolase 分子名称: 3-BENZYL-3-METHYL-5-(1-METHYLPYRAZOL-4-YL)INDOLIN-2-ONE, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-08 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5AM5	ligand complex structure of soluble epoxide hydrolase 分子名称: 5-cyclohexyl-3-propyl-1H-pyridin-2-one, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-09 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5ALT	ligand complex structure of soluble epoxide hydrolase 分子名称: 3-(2-methyltetrazol-5-yl)-5-(3-thienyl)pyridin-2-amine, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DI(HYDROXYETHYL)ETHER, ... 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-08 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5AM4	ligand complex structure of soluble epoxide hydrolase 分子名称: 5-cyclohexylspiro[1H-indole-3,4'-oxane]-2-one, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, ... 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-09 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5ALU	ligand complex structure of soluble epoxide hydrolase 分子名称: 4-cyclopentyl-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-2-[[(3S)-oxolan-3-yl]amino]pyrimidine-5-carboxamide, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-08 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5ALV	ligand complex structure of soluble epoxide hydrolase 分子名称: 3-(3-fluorophenyl)-1H-pyrazole, BIFUNCTIONAL EPOXIDE HYDROLASE 2, SULFATE ION 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-08 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5ALN	ligand complex structure of soluble epoxide hydrolase 分子名称: 5-(4-FLUOROPHENYL)-3,3-DIMETHYL-INDOLIN-2-ONE, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, ... 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-08 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5ALZ	ligand complex structure of soluble epoxide hydrolase 分子名称: 1-(1-adamantyl)-3-(1-methylsulfonylpiperidin-4-yl)urea, BIFUNCTIONAL EPOXIDE HYDROLASE 2, SULFATE ION 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-08 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5ALX	ligand complex structure of soluble epoxide hydrolase 分子名称: 5-(3-ethylsulfanylphenyl)thiophene-2-carboxamide, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, ... 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-08 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5ALQ	ligand complex structure of soluble epoxide hydrolase 分子名称: 1-(3-PHENYL-1H-PYRAZOL-5-YL)CYCLOPENTANOL, BIFUNCTIONAL EPOXIDE HYDROLASE 2, SULFATE ION 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-08 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5ALY	ligand complex structure of soluble epoxide hydrolase 分子名称: 5-(7-fluoranyl-3,3-dimethyl-2-oxidanylidene-1H-indol-5-yl)-4-methyl-1H-pyrazole-3-carbonitrile, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, ... 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-08 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5ALR	ligand complex structure of soluble epoxide hydrolase 分子名称: BIFUNCTIONAL EPOXIDE HYDROLASE 2, N-[4-(TRIFLUOROMETHYLSULFANYL)PHENYL]QUINAZOLIN-4-AMINE, SULFATE ION 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-08 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5ALW	ligand complex structure of soluble epoxide hydrolase 分子名称: 5-[2-(4-methylphenyl)sulfanylethanoyl]-1,3-dihydroindol-2-one, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, ... 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-08 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5ALP	ligand complex structure of soluble epoxide hydrolase 分子名称: BIFUNCTIONAL EPOXIDE HYDROLASE 2, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-08 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015
5AM0	ligand complex structure of soluble epoxide hydrolase 分子名称: 7-fluoranyl-3,3-dimethyl-5-(1-methylpyrrol-2-yl)-1H-indol-2-one, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, ... 著者 Oster, L, Tapani, S, Xue, Y, Kack, H. 登録日 2015-03-08 公開日 2015-05-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Successful Generation of Structural Information for Fragment-Based Drug Discovery. Drug Discov Today, 20, 2015

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