6Z2J
| The structure of the dimeric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex | Descriptor: | Deoxynucleotidyltransferase terminal-interacting protein 1, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Fairall, L, Saleh, A, Ragan, T.J, Millard, C.J, Savva, C.G, Schwabe, J.W.R. | Deposit date: | 2020-05-16 | Release date: | 2020-07-08 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure. Nat Commun, 11, 2020
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6Z2K
| The structure of the tetrameric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex | Descriptor: | Deoxynucleotidyltransferase terminal-interacting protein 1, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Fairall, L, Saleh, A, Ragan, T.J, Millard, C.J, Savva, C.G, Schwabe, J.W.R. | Deposit date: | 2020-05-16 | Release date: | 2020-07-08 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure. Nat Commun, 11, 2020
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5ICN
| HDAC1:MTA1 in complex with inositol-6-phosphate and a novel peptide inhibitor based on histone H4 | Descriptor: | GLY-ALA-6A0-ARG-HIS, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Millard, C.J, Robertson, N.S, Watson, P.J, Jameson, A.G, Schwabe, J.W.R. | Deposit date: | 2016-02-23 | Release date: | 2016-05-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Insights into the activation mechanism of class I HDAC complexes by inositol phosphates. Nat Commun, 7, 2016
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4BKX
| The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex | Descriptor: | ACETATE ION, HISTONE DEACETYLASE 1, METASTASIS-ASSOCIATED PROTEIN MTA1, ... | Authors: | Millard, C.J, Watson, P.J, Celardo, I, Gordiyenko, Y, Cowley, S.M, Robinson, C.V, Fairall, L, Schwabe, J.W.R. | Deposit date: | 2013-04-30 | Release date: | 2013-07-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Class I Hdacs Share a Common Mechanism of Regulation by Inositol Phosphates. Mol.Cell, 51, 2013
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7SME
| p107 pocket domain complexed with HDAC1 peptide | Descriptor: | Histone deacetylase 1, Retinoblastoma-like protein 1, SULFATE ION | Authors: | Putta, S, Fernandez, S.M, Tripathi, S.M, Muller, G.A, Rubin, S.M. | Deposit date: | 2021-10-25 | Release date: | 2022-06-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family. Structure, 30, 2022
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7AOA
| Structure of the extended MTA1/HDAC1/MBD2/RBBP4 NURD deacetylase complex | Descriptor: | Histone deacetylase 1, Histone-binding protein RBBP4, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Millard, C.J, Fairall, L, Ragan, T.J, Savva, C.G, Schwabe, J.W.R. | Deposit date: | 2020-10-14 | Release date: | 2020-11-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (19.4 Å) | Cite: | The topology of chromatin-binding domains in the NuRD deacetylase complex. Nucleic Acids Res., 48, 2020
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7AO9
| Structure of the core MTA1/HDAC1/MBD2 NURD deacetylase complex | Descriptor: | Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, Metastasis-associated protein MTA1, ... | Authors: | Millard, C.J, Fairall, L, Ragan, T.J, Savva, C.G, Schwabe, J.W.R. | Deposit date: | 2020-10-14 | Release date: | 2020-11-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (6.1 Å) | Cite: | The topology of chromatin-binding domains in the NuRD deacetylase complex. Nucleic Acids Res., 48, 2020
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7AO8
| Structure of the MTA1/HDAC1/MBD2 NURD deacetylase complex | Descriptor: | Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, Metastasis-associated protein MTA1, ... | Authors: | Millard, C.J, Fairall, L, Ragan, T.J, Savva, C.G, Schwabe, J.W.R. | Deposit date: | 2020-10-14 | Release date: | 2020-11-11 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | The topology of chromatin-binding domains in the NuRD deacetylase complex. Nucleic Acids Res., 48, 2020
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4D6K
| Structure of DNTTIP1 dimerisation domain. | Descriptor: | DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1 | Authors: | Itoh, T, Fairall, L, Schwabe, J.W.R. | Deposit date: | 2014-11-11 | Release date: | 2015-02-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and Functional Characterization of a Cell Cycle Associated Hdac1/2 Complex Reveals the Structural Basis for Complex Assembly and Nucleosome Targeting. Nucleic Acids Res., 43, 2015
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2MWI
| The structure of the carboxy-terminal domain of DNTTIP1 | Descriptor: | Deoxynucleotidyltransferase terminal-interacting protein 1 | Authors: | Schwabe, J.W.R, Muskett, F.W, Itoh, T. | Deposit date: | 2014-11-11 | Release date: | 2015-02-18 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting. Nucleic Acids Res., 43, 2015
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4BAY
| Phosphomimetic mutant of LSD1-8a splicing variant in complex with CoREST | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1 | Authors: | Toffolo, E, Paganini, L, Rusconi, F, Tortorici, M, Pilotto, S, Verpelli, C, Tedeschi, G, Maffioli, E, Sala, C, Mattevi, A, Battaglioli, E. | Deposit date: | 2012-09-17 | Release date: | 2013-11-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Phosphorylation of Neuronal Lysine-Specific Demethylase 1Lsd1/Kdm1A Impairs Transcriptional Repression by Regulating Interaction with Corest and Histone Deacetylases Hdac1/2. J.Neurochem., 128, 2014
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5IWG
| HDAC2 WITH LIGAND BRD4884 | Descriptor: | 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Steinbacher, S. | Deposit date: | 2016-03-22 | Release date: | 2016-08-31 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg.Med.Chem., 24, 2016
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5IX0
| HDAC2 WITH LIGAND BRD7232 | Descriptor: | (3-exo)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-8-oxabicyclo[3.2.1]octane-3-carboxamide, 1,2-ETHANEDIOL, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, ... | Authors: | Steinbacher, S. | Deposit date: | 2016-03-23 | Release date: | 2016-08-31 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg.Med.Chem., 24, 2016
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1OW1
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7SMF
| p107 pocket domain complexed with mutated HDAC1-3X peptide | Descriptor: | Histone deacetylase 1, Retinoblastoma-like protein 1, SULFATE ION | Authors: | Putta, S, Fernandez, S.M, Tripathi, S.M, Muller, G.A, Rubin, S.M. | Deposit date: | 2021-10-25 | Release date: | 2022-06-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family. Structure, 30, 2022
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4CZZ
| Histone demethylase LSD1(KDM1A)-CoREST3 Complex | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 3 | Authors: | Barrios, A.P, Gomez, A.V, Saez, J.E, Ciossani, G, Toffolo, E, Battaglioli, E, Mattevi, A, Andres, M.E. | Deposit date: | 2014-04-23 | Release date: | 2014-06-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Differential Properties of Transcriptional Complexes Formed by the Corest Family. Mol.Cell.Biol., 34, 2014
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4P6Q
| The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA Recognition Motifs | Descriptor: | Msx2-interacting protein, SULFATE ION | Authors: | Arieti, F, Gabus, C, Tambalo, M, Huet, T, Round, A, Thore, S. | Deposit date: | 2014-03-25 | Release date: | 2014-05-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA recognition motifs. Nucleic Acids Res., 42, 2014
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2RT5
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8I60
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2VCG
| Crystal structure of a HDAC-like protein HDAH from Bordetella sp. with the bound inhibitor ST-17 | Descriptor: | CHLORIDE ION, GLYCEROL, HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE, ... | Authors: | Dickmanns, A, Strasser, A, Ficner, R. | Deposit date: | 2007-09-24 | Release date: | 2008-01-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Phenylalanine-Containing Hydroxamic Acids as Selective Inhibitors of Class Iib Histone Deacetylases (Hdacs). Bioorg.Med.Chem., 16, 2008
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1WQ6
| The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity | Descriptor: | AML1-ETO | Authors: | Liu, Y, Cheney, M.D, Chruszcz, M, Lukasik, S.M, Hartman, K.L, Laue, T.M, Dauter, Z, Minor, W, Speck, N.A, Bushweller, J.H. | Deposit date: | 2004-09-23 | Release date: | 2005-10-04 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity Cancer Cell, 9, 2006
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7Z1K
| Crystal structure of the SPOC domain of human SHARP (SPEN) in complex with RNA polymerase II CTD heptapeptide phosphorylated on Ser5 | Descriptor: | Msx2-interacting protein, SER-TYR-SER-PRO-THR-SEP | Authors: | Appel, L, Grishkovskaya, I, Slade, D, Djinovic-Carugo, K. | Deposit date: | 2022-02-24 | Release date: | 2022-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators. Nat Commun, 14, 2023
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5KXF
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6HSK
| Crystal structure of a human HDAC8 L6 loop mutant complexed with Quisinostat | Descriptor: | 2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]-~{N}-oxidanyl-pyrimidine-5-carboxamide, Histone deacetylase 8, POTASSIUM ION, ... | Authors: | Marek, M, Shaik, T.B, Ramos-Morales, E, Romier, C. | Deposit date: | 2018-10-01 | Release date: | 2018-10-31 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.096 Å) | Cite: | Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
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4ZQA
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