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4YSI
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BU of 4ysi by Molmil
Structure of USP7 with a novel viral protein
Descriptor: GLYCEROL, SER-PRO-GLY-GLU-GLY-PRO-SER-GLY, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Chavoshi, S, Saridakis, V.
Deposit date:2015-03-17
Release date:2016-02-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Structure of USP7 with a novel viral protein
J.Biol.Chem., 2016
4Z96
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BU of 4z96 by Molmil
Crystal structure of DNMT1 in complex with USP7
Descriptor: DNA (cytosine-5)-methyltransferase 1, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Zhang, Z.M, Song, J.
Deposit date:2015-04-09
Release date:2016-10-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal structure of DNMT1 in complex with USP7
To Be Published
4Z97
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BU of 4z97 by Molmil
Crystal structure of USP7 in complex with DNMT1(K1115Q)
Descriptor: DNA (cytosine-5)-methyltransferase 1, GLYCEROL, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Zhang, Z.M, Song, J.
Deposit date:2015-04-09
Release date:2016-10-12
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.998 Å)
Cite:Crystal structure of USP7 in complex with DNMT1(K1115Q)
To Be Published
5VSB
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BU of 5vsb by Molmil
Structure of DUB complex
Descriptor: 7-chloro-3-{[4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl]methyl}quinazolin-4(3H)-one, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2017-05-11
Release date:2017-12-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Cell Chem Biol, 24, 2017
5VS6
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BU of 5vs6 by Molmil
Structure of DUB complex
Descriptor: ACETATE ION, GLYCEROL, N-[3-({4-hydroxy-1-[(3R)-3-phenylbutanoyl]piperidin-4-yl}methyl)-4-oxo-3,4-dihydroquinazolin-7-yl]-3-(4-methylpiperazin-1-yl)propanamide, ...
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2017-05-11
Release date:2017-12-20
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Cell Chem Biol, 24, 2017
5VSK
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BU of 5vsk by Molmil
Structure of DUB complex
Descriptor: 7-chloro-3-({4-hydroxy-1-[(3S)-3-phenylbutanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one, Ubiquitin carboxyl-terminal hydrolase 7, ZINC ION
Authors:Seo, H.-Y, Dhe-Paganon, S.
Deposit date:2017-05-11
Release date:2017-12-20
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Cell Chem Biol, 24, 2017
2F1Z
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BU of 2f1z by Molmil
Crystal structure of HAUSP
Descriptor: Ubiquitin carboxyl-terminal hydrolase 7
Authors:Hu, M, Gu, L, Jeffrey, P.D, Shi, Y.
Deposit date:2005-11-15
Release date:2006-02-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
5VBT
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BU of 5vbt by Molmil
Crystal structure of a highly specific and potent USP7 ubiquitin variant inhibitor
Descriptor: UBH04
Authors:DONG, A, DONG, X, LIU, L, GUO, Y, LI, Y, ZHANG, W, WALKER, J.R, SIDHU, S, Bountra, C, Arrowsmith, C.H, Edwards, A.M, TONG, Y, Structural Genomics Consortium (SGC)
Deposit date:2017-03-30
Release date:2017-06-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Crystal structure of a highly specific and potent USP7 ubiquitin variant inhibitor
to be published
4JJQ
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BU of 4jjq by Molmil
Crystal structure of usp7-ntd with an e2 enzyme
Descriptor: Ubiquitin carboxyl-terminal hydrolase 7, Ubiquitin-conjugating enzyme E2 E1
Authors:Saridakis, V.
Deposit date:2013-03-08
Release date:2013-05-01
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Ubiquitin-specific protease 7 is a regulator of ubiquitin-conjugating enzyme UbE2E1.
J. Biol. Chem., 288, 2013
5GG4
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BU of 5gg4 by Molmil
Crystal structure of USP7 with RNF169 peptide
Descriptor: Peptide from E3 ubiquitin-protein ligase RNF169, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Jiang, Y, Gong, Q.
Deposit date:2016-06-15
Release date:2017-03-22
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Dual-utility NLS drives RNF169-dependent DNA damage responses.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4HK2
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BU of 4hk2 by Molmil
U7Ub25.2540
Descriptor: SULFATE ION, Ubiquitin
Authors:Murray, J.M, Rouge, L.
Deposit date:2012-10-14
Release date:2012-11-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Potent and selective inhibitors of USP7/HAUSP activity by protein conformational stabilization
to be published
4HJK
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BU of 4hjk by Molmil
U7Ub7 Disulfide variant
Descriptor: PHOSPHATE ION, Ubiquitin
Authors:Murray, J.M, Rouge, L.
Deposit date:2012-10-12
Release date:2012-11-21
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.784 Å)
Cite:Potent and selective inhibitors of USP7/HAUSP activity by protein conformational stabilization
to be published
6P5L
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BU of 6p5l by Molmil
Crystal Structure of Ubl123 with an EZH2 peptide
Descriptor: PRO-ARG-LYS-LYS-LYS-ARG-LYS-HIS, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Saridakis, V.
Deposit date:2019-05-30
Release date:2020-05-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.296 Å)
Cite:Structural Basis of the Interaction Between Ubiquitin Specific Protease 7 and Enhancer of Zeste Homolog 2.
J.Mol.Biol., 432, 2020
6GDJ
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BU of 6gdj by Molmil
Crystal structure of Mto2 twin-cysteine dimerisation domain
Descriptor: GLYCEROL, Mto2
Authors:Thakur, H.C, Sawin, K.E, Cook, A.G.
Deposit date:2018-04-23
Release date:2019-05-01
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of Mto2 twin-cysteine dimerisation domain
To Be Published
1NB8
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BU of 1nb8 by Molmil
Structure of the catalytic domain of USP7 (HAUSP)
Descriptor: Ubiquitin carboxyl-terminal hydrolase 7
Authors:Hu, M, Li, P, Li, M, Li, W, Yao, T, Wu, J.-W, Gu, W, Cohen, R.E, Shi, Y.
Deposit date:2002-12-02
Release date:2003-01-07
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
Cell(Cambridge,Mass.), 111, 2002
5TOG
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BU of 5tog by Molmil
Room temperature structure of ubiquitin variant u7ub25.2540
Descriptor: Polyubiquitin-B, SULFATE ION
Authors:Biel, J.T, Thompson, M.C, Cunningham, C.N, Corn, J.E, Fraser, J.S.
Deposit date:2016-10-17
Release date:2017-05-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin.
Structure, 25, 2017
5TOF
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BU of 5tof by Molmil
Room temperature structure of ubiquitin variant u7ub25
Descriptor: Polyubiquitin-B, SULFATE ION
Authors:Biel, J.T, Thompson, M.C, Cunningham, C.N, Corn, J.E, Fraser, J.S.
Deposit date:2016-10-17
Release date:2017-05-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin.
Structure, 25, 2017
4Y2E
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BU of 4y2e by Molmil
Crystal structure of the catalytic domain of human dual-specificity phosphatase 7 (C232S)
Descriptor: Dual specificity protein phosphatase 7, PHOSPHATE ION
Authors:Lountos, G.T, Austin, B.P, Tropea, J.E, Waugh, D.S.
Deposit date:2015-02-09
Release date:2015-06-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structure of human dual-specificity phosphatase 7, a potential cancer drug target.
Acta Crystallogr.,Sect.F, 71, 2015
8ITP
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BU of 8itp by Molmil
Crystal structure of USP47 catalytic domain complex with ubiquitin
Descriptor: Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 47, ZINC ION
Authors:Kim, E.E, Shin, S.C.
Deposit date:2023-03-22
Release date:2024-03-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and functional characterization of USP47 reveals a hot spot for inhibitor design.
Commun Biol, 6, 2023
8ITN
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BU of 8itn by Molmil
Crystal structure of USP47apo catalytic domain
Descriptor: Ubiquitin carboxyl-terminal hydrolase 47, ZINC ION
Authors:Kim, E.E, Shin, S.C.
Deposit date:2023-03-22
Release date:2024-03-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional characterization of USP47 reveals a hot spot for inhibitor design.
Commun Biol, 6, 2023
8QH5
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BU of 8qh5 by Molmil
CryoEM structure of UVSSA(VHS)-CSA-DDB1-DDA1
Descriptor: DET1- and DDB1-associated protein 1, DNA damage-binding protein 1, DNA excision repair protein ERCC-8, ...
Authors:Lee, S.-H, Sixma, T.K.
Deposit date:2023-09-06
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:CryoEM structure of UVSSA(VHS)-CSA-DDB1-DDA1
To Be Published
2XXN
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BU of 2xxn by Molmil
Structure of the vIRF4-HAUSP TRAF domain complex
Descriptor: K10, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7
Authors:Choi, W.C, Hwang, J, Kim, M.H.
Deposit date:2010-11-11
Release date:2011-11-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Bilateral Inhibition of Hausp Deubiquitinase by a Viral Interferon Regulatory Factor Protein
Nat.Struct.Mol.Biol., 18, 2011
6GHA
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BU of 6gha by Molmil
USP15 catalytic domain structure
Descriptor: Ubiquitin carboxyl-terminal hydrolase 15,Ubiquitin carboxyl-terminal hydrolase 15, ZINC ION
Authors:Ward, S.J, Gratton, H.E, Caulton, S.G, Emsley, J, Dreveny, I.
Deposit date:2018-05-06
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel.
J. Biol. Chem., 293, 2018
6GH9
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BU of 6gh9 by Molmil
USP15 catalytic domain in complex with small molecule
Descriptor: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, DIMETHYL SULFOXIDE, Ubiquitin carboxyl-terminal hydrolase 15, ...
Authors:Ward, S.J, Gratton, H.E, Caulton, S.G, Emsley, J, Dreveny, I.
Deposit date:2018-05-06
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel.
J. Biol. Chem., 293, 2018
8HJE
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BU of 8hje by Molmil
Vismodegib binds to the catalytical domain of human Ubiquitin-Specific Protease 28
Descriptor: 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, Ubiquitin carboxyl-terminal hydrolase 28
Authors:Shi, L, Wang, H, Xu, Z, Xiong, B, Zhang, N.
Deposit date:2022-11-23
Release date:2023-05-03
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure-based discovery of potent USP28 inhibitors derived from Vismodegib.
Eur.J.Med.Chem., 254, 2023

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