5VS6

Structure of DUB complex

Summary for 5VS6

• Entry DOI: 10.2210/pdb5vs6/pdb
• Related: 5VSB
• Descriptor: Ubiquitin carboxyl-terminal hydrolase 7, N-[3-({4-hydroxy-1-[(3R)-3-phenylbutanoyl]piperidin-4-yl}methyl)-4-oxo-3,4-dihydroquinazolin-7-yl]-3-(4-methylpiperazin-1-yl)propanamide, ACETATE ION, ... (5 entities in total)
• Functional Keywords: deubiquitinase, inhibitor, protein-inhibitor complex, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q93009
• Total number of polymer chains: 2
• Total formula weight: 83368.29

Authors

Seo, H.-S.,Dhe-Paganon, S. (deposition date: 2017-05-11, release date: 2017-12-20, Last modification date: 2018-01-03)

• Primary citation: Lamberto, I.,Liu, X.,Seo, H.S.,Schauer, N.J.,Iacob, R.E.,Hu, W.,Das, D.,Mikhailova, T.,Weisberg, E.L.,Engen, J.R.,Anderson, K.C.,Chauhan, D.,Dhe-Paganon, S.,Buhrlage, S.J.; Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.; Cell Chem Biol, 24:1490-1500.e11, 2017; PubMed: 29056421; DOI: 10.1016/j.chembiol.2017.09.003

Experimental method

X-RAY DIFFRACTION (2.27 Å)