PDB: 908 resultsInfo pagesStatus searchChemie searchBIRD

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6J6H	Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom Descriptor: ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... Authors: Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. Deposit date: 2019-01-15 Release date: 2019-04-24 Last modified: 2020-10-14 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
6J6N	Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom Descriptor: GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... Authors: Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. Deposit date: 2019-01-15 Release date: 2019-04-24 Last modified: 2020-10-14 Method: ELECTRON MICROSCOPY (3.86 Å) Cite: Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
6J6Q	Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom Descriptor: GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... Authors: Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. Deposit date: 2019-01-15 Release date: 2019-04-24 Last modified: 2020-10-14 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
6DBP	RNA-recognition motif 1 of human MSI2 Descriptor: RNA-binding protein Musashi homolog 2 Authors: Goldgur, Y, Kharas, M.G, Minuesa, G. Deposit date: 2018-05-03 Release date: 2019-05-08 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.603 Å) Cite: Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nat Commun, 10, 2019
5ZUH	Solution structure of RRM domain of La protein from Trypanosoma brucei Descriptor: RNA binding protein La-like protein Authors: Shan, F.Z. Deposit date: 2018-05-07 Release date: 2019-05-15 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: A telomerase subunit homolog La protein from Trypanosoma brucei plays an essential role in ribosomal biogenesis. Febs J., 286, 2019
6R5K	Cryo-EM structure of a poly(A) RNP bound to the Pan2-Pan3 deadenylase Descriptor: MAGNESIUM ION, PAN2-PAN3 deadenylation complex catalytic subunit PAN2, PAN2-PAN3 deadenylation complex subunit PAN3, ... Authors: Schaefer, I.B, Conti, E. Deposit date: 2019-03-25 Release date: 2019-05-29 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase. Cell, 177, 2019
6NSX	Yeast Hsh155 Ligand bound to Human Tat-SF1 Motif Descriptor: CHLORIDE ION, HIV Tat-specific factor 1, Hsh155 Authors: Jenkins, J.L, Leach, J.R, Kielkopf, C.L. Deposit date: 2019-01-25 Release date: 2019-06-05 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interaction. Rna, 25, 2019
6NCQ	The dimerization domain of human SFPQ in space group C2221 Descriptor: Splicing factor, proline- and glutamine-rich Authors: Lee, M. Deposit date: 2018-12-12 Release date: 2019-06-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A new crystal structure and small-angle X-ray scattering analysis of the homodimer of human SFPQ. Acta Crystallogr.,Sect.F, 75, 2019
6GSN	Structure of a partial yeast 48S preinitiation complex in closed conformation Descriptor: 18S rRNA (1798-MER), 40S ribosomal protein S0, 40S ribosomal protein S1, ... Authors: Llacer, J.L, Hussain, T, Ramakrishnan, V. Deposit date: 2018-06-14 Release date: 2019-06-26 Last modified: 2021-10-27 Method: ELECTRON MICROSCOPY (5.75 Å) Cite: Large-scale movement of eIF3 domains during translation initiation modulate start codon selection. Nucleic Acids Res., 2021
6NWW	Crystal structure of the RRM domain of S. pombe Puf1 in the P212121 space group Descriptor: CHLORIDE ION, Pumilio domain-containing protein C56F2.08c Authors: Qiu, C, Hall, T.M.T. Deposit date: 2019-02-07 Release date: 2019-07-03 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Distinct RNA-binding modules in a single PUF protein cooperate to determine RNA specificity. Nucleic Acids Res., 47, 2019
6NX5	Crystal structure of the RRM domain of S. pombe Puf1 in the P21 space group Descriptor: 1,2-ETHANEDIOL, Pumilio domain-containing protein C56F2.08c Authors: Qiu, C, Hall, T.M.T. Deposit date: 2019-02-08 Release date: 2019-07-03 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.554 Å) Cite: Distinct RNA-binding modules in a single PUF protein cooperate to determine RNA specificity. Nucleic Acids Res., 47, 2019
6N7X	S. cerevisiae U1 snRNP Descriptor: 56 kDa U1 small nuclear ribonucleoprotein component, Pre-mRNA-processing factor 39, Protein NAM8, ... Authors: Li, X, Liu, S, Jiang, J, Zhang, L, Espinosa, S, Hill, R.C, Hansen, K.C, Zhou, Z.H, Zhao, R. Deposit date: 2018-11-28 Release date: 2019-07-24 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing. Nat Commun, 8, 2017
6GSM	Structure of a partial yeast 48S preinitiation complex in open conformation. Descriptor: 18S ribosomal RNA, 40S ribosomal protein S0, 40S ribosomal protein S1, ... Authors: Llacer, J.L, Hussain, T, Gordiyenko, Y, Ramakrishnan, V. Deposit date: 2018-06-14 Release date: 2019-07-31 Last modified: 2023-02-22 Method: ELECTRON MICROSCOPY (5.2 Å) Cite: Large-scale movement of eIF3 domains during translation initiation modulate start codon selection. Nucleic Acids Res., 2021
6DG0	MEC-8 C-terminal RRM domain bound to AGCACA Descriptor: DNA (5'-D(*AP*GP*CP*AP*CP*A)-3'), Mec-8 protein Authors: Mackereth, C.D, Soufari, H. Deposit date: 2018-05-16 Release date: 2019-08-21 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.457 Å) Cite: Structure of MEC-8 RRM2 in complex with AGCACA To Be Published
6PAI	Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and sulfonamide E7820 Descriptor: 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DDB1- and CUL4-associated factor 15, ... Authors: Volkov, O.A, Du, X. Deposit date: 2019-06-11 Release date: 2019-09-18 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820. Structure, 27, 2019
6N7P	S. cerevisiae spliceosomal E complex (UBC4) Descriptor: 56 kDa U1 small nuclear ribonucleoprotein component, Nuclear cap-binding protein complex subunit 1, Nuclear cap-binding protein subunit 2, ... Authors: Liu, S, Li, X, Zhou, Z.H, Zhao, R. Deposit date: 2018-11-27 Release date: 2019-09-18 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: A unified mechanism for intron and exon definition and back-splicing. Nature, 573, 2019
6N7R	Saccharomyces cerevisiae spliceosomal E complex (ACT1) Descriptor: 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA, Pre-mRNA-processing factor 39, ... Authors: Liu, S, Li, X, Zhou, Z.H, Zhao, R. Deposit date: 2018-11-28 Release date: 2019-09-18 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: A unified mechanism for intron and exon definition and back-splicing. Nature, 573, 2019
6SXW	Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638) Descriptor: SULFATE ION, Zinc finger protein 638 Authors: Newman, J.A, Aitkenhead, H, Wang, D, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. Deposit date: 2019-09-26 Release date: 2019-10-16 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.751 Å) Cite: Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638) To Be Published
6NTY	2.1 A resolution structure of the Musashi-2 (Msi2) RNA recognition motif 1 (RRM1) domain Descriptor: PHOSPHATE ION, RNA-binding protein Musashi homolog 2 Authors: Lovell, S, Kashipathy, M.M, Battaile, K.P, Lan, L, Xiaoqing, W, Cooper, A, Gao, F.P, Xu, L. Deposit date: 2019-01-30 Release date: 2019-10-23 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal and solution structures of human oncoprotein Musashi-2 N-terminal RNA recognition motif 1. Proteins, 88, 2020
6Q0W	Structure of DDB1-DDA1-DCAF15 complex bound to Indisulam and RBM39 Descriptor: DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1, ... Authors: Faust, T, Yoon, H, Nowak, R.P, Donovan, K.A, Li, Z, Cai, Q, Eleuteri, N.A, Zhang, T, Gray, N.S, Fischer, E.S. Deposit date: 2019-08-02 Release date: 2019-11-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nat.Chem.Biol., 16, 2020
6Q0R	Structure of DDB1-DDA1-DCAF15 complex bound to E7820 and RBM39 Descriptor: 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide, DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, ... Authors: Faust, T, Yoon, H, Nowak, R.P, Donovan, K.A, Li, Z, Cai, Q, Eleuteri, N.A, Zhang, T, Gray, N.S, Fischer, E.S. Deposit date: 2019-08-02 Release date: 2019-11-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nat.Chem.Biol., 16, 2020
6Q0V	Structure of DDB1-DDA1-DCAF15 complex bound to tasisulam and RBM39 Descriptor: DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1, ... Authors: Faust, T, Yoon, H, Nowak, R.P, Donovan, K.A, Li, Z, Cai, Q, Eleuteri, N.A, Zhang, T, Gray, N.S, Fischer, E.S. Deposit date: 2019-08-02 Release date: 2019-11-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nat.Chem.Biol., 16, 2020
6SJ7	Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and Indisulam Descriptor: DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1, ... Authors: Srinivas, H. Deposit date: 2019-08-12 Release date: 2019-12-18 Last modified: 2019-12-25 Method: ELECTRON MICROSCOPY (3.54 Å) Cite: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex. Nat.Chem.Biol., 16, 2020
6UD7	Crystal structure of full-length human DCAF15-DDB1(deltaBPB)-DDA1-RBM39 in complex with indisulam Descriptor: DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1,DNA damage-binding protein 1, ... Authors: Bussiere, D.E, Shu, W, Xie, L, Knapp, M. Deposit date: 2019-09-18 Release date: 2019-12-18 Last modified: 2020-01-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex. Nat.Chem.Biol., 16, 2020
6UE5	Crystal structure of full-length human DCAF15-DDB1-deltaPBP-DDA1-RBM39 in complex with 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide Descriptor: 4-(aminomethyl)-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide, DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, ... Authors: Knapp, M.S, Shu, W, Xie, L, Bussiere, D.E. Deposit date: 2019-09-20 Release date: 2019-12-18 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.61 Å) Cite: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex. Nat.Chem.Biol., 16, 2020

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