6PAI

Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and sulfonamide E7820

Summary for 6PAI

• Entry DOI: 10.2210/pdb6pai/pdb
• Descriptor: DNA damage-binding protein 1, DDB1- and CUL4-associated factor 15, RNA-binding protein 39, ... (8 entities in total)
• Functional Keywords: sulfonamide, rbm39, dcaf15, ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 208344.63

Authors

Volkov, O.A.,Du, X. (deposition date: 2019-06-11, release date: 2019-09-18, Last modification date: 2023-10-11)

• Primary citation: Du, X.,Volkov, O.A.,Czerwinski, R.M.,Tan, H.,Huerta, C.,Morton, E.R.,Rizzi, J.P.,Wehn, P.M.,Xu, R.,Nijhawan, D.,Wallace, E.M.; Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820.; Structure, 27:1625-1633.e3, 2019; PubMed: 31693911; DOI: 10.1016/j.str.2019.10.005

Experimental method

X-RAY DIFFRACTION (2.9 Å)