6D8Z
| |
1NTY
| |
5JHH
| Crystal structure of the ternary complex between the human RhoA, its inhibitor and the DH/PH domain of human ARHGEF11 | Descriptor: | 3-{3-[ethyl(quinolin-2-yl)amino]phenyl}propanoic acid, GLYCEROL, Rho guanine nucleotide exchange factor 11, ... | Authors: | Lv, Z, Wang, R, Ma, L, Miao, Q, Wu, J, Yan, Z, Li, J, Miao, L, Wang, F. | Deposit date: | 2016-04-21 | Release date: | 2017-04-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and PDZRhoGEF To Be Published
|
|
4MT6
| |
5JHG
| Crystal structure of the complex between the human RhoA and the DH/PH domain of human ARHGEF11 | Descriptor: | GLYCEROL, Rho guanine nucleotide exchange factor 11, Transforming protein RhoA | Authors: | Wang, R, Chen, Q, Zhang, H, Yan, Z, Li, J, Miao, L, Wang, F. | Deposit date: | 2016-04-21 | Release date: | 2017-04-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and ARHGEF11 To Be Published
|
|
4MT7
| Crystal structure of collybistin I | Descriptor: | Rho guanine nucleotide exchange factor 9 | Authors: | Schneeberger, D, Schindelin, H. | Deposit date: | 2013-09-19 | Release date: | 2014-08-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | A conformational switch in collybistin determines the differentiation of inhibitory postsynapses. Embo J., 33, 2014
|
|
1FOE
| |
4D0N
| AKAP13 (AKAP-Lbc) RhoGEF domain in complex with RhoA | Descriptor: | 1,2-ETHANEDIOL, A-KINASE ANCHOR PROTEIN 13, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Abdul Azeez, K.R, Shrestha, L, Krojer, T, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Klussmann, E, Elkins, J.M. | Deposit date: | 2014-04-29 | Release date: | 2014-05-21 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex. Biochem.J., 464, 2014
|
|
2DX1
| Crystal structure of RhoGEF protein Asef | Descriptor: | Rho guanine nucleotide exchange factor 4 | Authors: | Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-08-22 | Release date: | 2007-01-02 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism J.Biol.Chem., 282, 2007
|
|
1RJ2
| |
2DFK
| Crystal structure of the CDC42-Collybistin II complex | Descriptor: | GLYCEROL, SULFATE ION, cell division cycle 42 isoform 1, ... | Authors: | Xiang, S, Kim, E.Y, Connelly, J.J, Nassar, N, Kirsch, J, Winking, J, Schwarz, G, Schindelin, H. | Deposit date: | 2006-03-02 | Release date: | 2006-05-02 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The Crystal Structure of Cdc42 in Complex with Collybistin II, a Gephyrin-interacting Guanine Nucleotide Exchange Factor. J.Mol.Biol., 359, 2006
|
|
2VRW
| |
2NZ8
| N-terminal DHPH cassette of Trio in complex with nucleotide-free Rac1 | Descriptor: | ras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein | Authors: | Chhatriwala, M.K, Betts, L, Worthylake, D.K, Sondek, J. | Deposit date: | 2006-11-22 | Release date: | 2007-04-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation J.Mol.Biol., 368, 2007
|
|
5O33
| A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1 | Descriptor: | 1,2-ETHANEDIOL, GUANOSINE-5'-DIPHOSPHATE, Kalirin, ... | Authors: | Gray, J, Krojer, T, Talon, R, Fairhead, M, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P, von Delft, F. | Deposit date: | 2017-05-23 | Release date: | 2017-05-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1 To Be Published
|
|
7RX9
| Structure of autoinhibited P-Rex1 | Descriptor: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Endolysin chimera, SULFATE ION | Authors: | Ellisdon, A.M, Chang, Y. | Deposit date: | 2021-08-22 | Release date: | 2022-08-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. Nat.Struct.Mol.Biol., 29, 2022
|
|
2PZ1
| Crystal Structure of Auto-inhibited Asef | Descriptor: | Rho guanine nucleotide exchange factor 4 | Authors: | Betts, L, Sondek, J, Rossman, K.L. | Deposit date: | 2007-05-17 | Release date: | 2007-08-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. Nat.Struct.Mol.Biol., 14, 2007
|
|
7SJ4
| Human Trio residues 1284-1959 in complex with Rac1 | Descriptor: | Ras-related C3 botulinum toxin substrate 1, Triple functional domain protein | Authors: | Chen, C.-L, Ravala, S.K, Bandekar, S.J, Cash, J, Tesmer, J.J.G. | Deposit date: | 2021-10-15 | Release date: | 2022-07-06 | Last modified: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1. J.Biol.Chem., 298, 2022
|
|
2Z0Q
| Crystal structure of DH-PH domain of RhoGEF3(Xpln) | Descriptor: | Rho guanine nucleotide exchange factor 3, SULFATE ION | Authors: | Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-05-07 | Release date: | 2008-05-13 | Last modified: | 2012-12-12 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structure of the Rho-specific guanine nucleotide-exchange factor Xpln Acta Crystallogr.,Sect.F, 68, 2012
|
|
7SYF
| Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1) | Descriptor: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Endolysin chimera | Authors: | Lupton, C.J, Bayly-Jones, C, Ellisdon, A.M. | Deposit date: | 2021-11-24 | Release date: | 2022-07-27 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. Nat.Struct.Mol.Biol., 29, 2022
|
|
2RGN
| Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... | Authors: | Shankaranarayanan, A, Nance, M.R, Tesmer, J.J.G. | Deposit date: | 2007-10-04 | Release date: | 2008-01-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science, 318, 2007
|
|
3BJI
| Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1 | Descriptor: | Proto-oncogene vav, Ras-related C3 botulinum toxin substrate 1 precursor, ZINC ION | Authors: | Chrencik, J.E, Brooun, A, Kuhn, P, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) | Deposit date: | 2007-12-04 | Release date: | 2008-07-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1. J.Mol.Biol., 380, 2008
|
|
4GZU
| Crystal structure of the DH-PH-PH domain of FARP2 | Descriptor: | FERM, RhoGEF and pleckstrin domain-containing protein 2 | Authors: | He, X, Zhang, X. | Deposit date: | 2012-09-06 | Release date: | 2013-03-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2. Structure, 21, 2013
|
|
4GOU
| Crystal structure of an RGS-RhoGEF from Entamoeba histolytica | Descriptor: | EhRGS-RhoGEF | Authors: | Bosch, D.E, Kimple, A.J, Muller, R.E, Willard, F.S, Machius, M, Siderovski, D.P. | Deposit date: | 2012-08-20 | Release date: | 2013-01-09 | Last modified: | 2013-01-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis. Structure, 21, 2013
|
|
4H6Y
| Crystal structure of the DH-PH-PH domain of FARP1 | Descriptor: | FERM, RhoGEF and pleckstrin domain-containing protein 1 | Authors: | He, X, Zhang, X. | Deposit date: | 2012-09-19 | Release date: | 2013-03-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (4.09 Å) | Cite: | Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2. Structure, 21, 2013
|
|
6L30
| Crystal structure of the epithelial cell transforming 2 (ECT2) | Descriptor: | Protein ECT2 | Authors: | Chen, Z.C, Chen, M.R, Pan, H, Sun, L.F, Shi, P. | Deposit date: | 2019-10-07 | Release date: | 2020-01-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure and regulation of human epithelial cell transforming 2 protein. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|