2ADJ
| Crystal structure of monoclonal anti-CD4 antibody Q425 in complex with Calcium | Descriptor: | CALCIUM ION, Q425 Fab Heavy chain, Q425 Fab Light chain | Authors: | Zhou, T, Hamer, D.H, Hendrickson, W.A, Sattentau, Q.J, Kwong, P.D. | Deposit date: | 2005-07-20 | Release date: | 2005-09-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Interfacial metal and antibody recognition. Proc.Natl.Acad.Sci.Usa, 102, 2005
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7NIP
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5EQY
| Crystal structure of choline kinase alpha-1 bound by 5-[(4-methyl-1,4-diazepan-1-yl)methyl]-2-[4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]benzenecarbonitrile (compound 65) | Descriptor: | 5-[(4-methyl-1,4-diazepan-1-yl)methyl]-2-[4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]benzenecarbonitrile, Choline kinase alpha | Authors: | Zhou, T, Zhu, X, Dalgarno, D.C. | Deposit date: | 2015-11-13 | Release date: | 2016-01-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery. J.Med.Chem., 59, 2016
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5EQE
| Crystal structure of choline kinase alpha-1 bound by [4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]methanamine (compound 11) | Descriptor: | Choline kinase alpha, [4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]methanamine | Authors: | Zhou, T, Zhu, X, Dalgarno, D.C. | Deposit date: | 2015-11-12 | Release date: | 2016-01-06 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery. J.Med.Chem., 59, 2016
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5EQP
| Crystal structure of choline kinase alpha-1 bound by 6-[(4-methyl-1,4-diazepan-1-yl)methyl]quinoline (compound 37) | Descriptor: | 6-[(4-methyl-1,4-diazepan-1-yl)methyl]quinoline, Choline kinase alpha | Authors: | Zhou, T, Zhu, X, Dalgarno, D.C. | Deposit date: | 2015-11-13 | Release date: | 2016-01-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery. J.Med.Chem., 59, 2016
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2NY7
| HIV-1 gp120 Envelope Glycoprotein Complexed with the Broadly Neutralizing CD4-Binding-Site Antibody b12 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY b12, HEAVY CHAIN, ... | Authors: | Zhou, T, Xu, L, Dey, B, Hessell, A.J, Van Ryk, D, Xiang, S.H, Yang, X, Zhang, M.Y, Zwick, M.B, Arthos, J, Burton, D.R, Dimitrov, D.S, Sodroski, J, Wyatt, R, Nabel, G.J, Kwong, P.D. | Deposit date: | 2006-11-20 | Release date: | 2007-02-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature, 445, 2007
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5VFK
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5WDX
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4PW6
| structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex II | Descriptor: | 5hmC-containing DNA1, 5hmC-containing DNA2, E3 ubiquitin-protein ligase UHRF2 | Authors: | Zhou, T, Xiong, J, Wang, M, Yang, N, Wong, J, Zhu, B, Xu, R.M. | Deposit date: | 2014-03-18 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.789 Å) | Cite: | Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2. Mol.Cell, 54, 2014
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4PW5
| structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex I | Descriptor: | 5hmC-containing DNA1, 5hmC-containing DNA2, E3 ubiquitin-protein ligase UHRF2 | Authors: | ZHou, T, Xiong, J, Wang, M, Yang, N, Wong, J, Zhu, B, Xu, R.M. | Deposit date: | 2014-03-18 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.204 Å) | Cite: | Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2. Mol.Cell, 54, 2014
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4PW7
| structure of UHRF2-SRA in complex with a 5mC-containing DNA | Descriptor: | 5mC-containing DNA1, 5mC-containing DNA2, E3 ubiquitin-protein ligase UHRF2 | Authors: | ZHou, T, Xiong, J, Wang, M, Yang, N, Wong, J, Zhu, B, Xu, R.M. | Deposit date: | 2014-03-19 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2. Mol.Cell, 54, 2014
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8F6X
| cryo-EM structure of a structurally designed Human metapneumovirus F protein in complex with antibody MPE8 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MPE8 Single chain variable fragment, Structurally designed HMPV F protein HMPV_v3B_D12_DS454,Fibritin | Authors: | Zhou, T, Kwong, P.D, Morano, N.C, Ou, L. | Deposit date: | 2022-11-17 | Release date: | 2023-08-02 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | cryo-EM structure of a structurally designed Human metapneumovirus F protein in complex with antibody MPE8 To Be Published
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5F9W
| Crystal structure of broadly neutralizing VH1-46 germline-derived CD4-binding site-directed antibody CH235 in complex with HIV-1 clade A/E 93TH057 gp120 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of CH235-lineage antibody CH235, Light chain of CH235-lineage antibody CH235, ... | Authors: | Chen, L, Zhou, T, Kwong, P.D. | Deposit date: | 2015-12-10 | Release date: | 2016-03-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8911 Å) | Cite: | Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody. Cell, 165, 2016
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5FYL
| Crystal Structure at 3.7 A Resolution of Fully Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122 and 35O22 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 ANTIBODY FAB HEAVY CHAIN, ... | Authors: | Stewart-Jones, G.B.E, Zhou, T, Thomas, P.V, Kwong, P.D. | Deposit date: | 2016-03-08 | Release date: | 2016-04-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G Cell(Cambridge,Mass.), 165, 2016
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5FYJ
| Crystal Structure at 3.4 A Resolution of Fully Glycosylated HIV-1 Clade G X1193.c1 SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122, 35O22 and VRC01 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Stewart-Jones, G.B.E, Zhou, T, Thomas, P.V, Kwong, P.D. | Deposit date: | 2016-03-08 | Release date: | 2016-04-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G Cell(Cambridge,Mass.), 165, 2016
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5FYK
| Crystal Structure at 3.7 A Resolution of Fully Glycosylated HIV-1 Clade B JR-FL SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122, 35O22 and VRC01 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22, ... | Authors: | Stewart-Jones, G.B.E, Zhou, T, Thomas, P.V, Kwong, P.D. | Deposit date: | 2016-03-08 | Release date: | 2016-04-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.107 Å) | Cite: | Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G Cell(Cambridge,Mass.), 165, 2016
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2QD0
| Crystal structure of mitoNEET | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, Zinc finger CDGSH domain-containing protein 1 | Authors: | Lin, J, Zhou, T, Ye, K, Wang, J. | Deposit date: | 2007-06-20 | Release date: | 2007-08-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins. Proc.Natl.Acad.Sci.Usa, 104, 2007
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1H72
| CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH HSE | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, HOMOSERINE KINASE, L-HOMOSERINE, ... | Authors: | Krishna, S.S, Zhou, T, Daugherty, M, Osterman, A.L, Zhang, H. | Deposit date: | 2001-07-02 | Release date: | 2001-09-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Basis for the Catalysis and Substrate Specificity of Homoserine Kinase Biochemistry, 40, 2001
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1H73
| CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH THREONINE | Descriptor: | HOMOSERINE KINASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, THREONINE | Authors: | Krishna, S.S, Zhou, T, Daugherty, M, Osterman, A.L, Zhang, H. | Deposit date: | 2001-07-02 | Release date: | 2001-09-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis for the Catalysis and Substrate Specificity of Homoserine Kinase Biochemistry, 40, 2001
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1H74
| CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH ILE | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, HOMOSERINE KINASE, ISOLEUCINE, ... | Authors: | Krishna, S.S, Zhou, T, Daugherty, M, Osterman, A.L, Zhang, H. | Deposit date: | 2001-07-02 | Release date: | 2001-11-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis for the Catalysis and Substrate Specificity of Homoserine Kinase Biochemistry, 40, 2001
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4TVP
| Crystal Structure of the HIV-1 BG505 SOSIP.664 Env Trimer Ectodomain, Comprising Atomic-Level Definition of Pre-Fusion gp120 and gp41, in Complex with Human Antibodies PGT122 and 35O22 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Heavy chain, ... | Authors: | Pancera, M, Zhou, T, Kwong, P.D. | Deposit date: | 2014-06-27 | Release date: | 2014-10-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature, 514, 2014
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5M2Q
| Structure of cobinamide-bound BtuF mutant W66F, the periplasmic vitamin B12 binding protein in E.coli | Descriptor: | COB(II)INAMIDE, CYANIDE ION, GLYCEROL, ... | Authors: | Mireku, S.A, Ruetz, M, Zhou, T, Korkhov, V.M, Kraeutler, B, Locher, K.P. | Deposit date: | 2016-10-13 | Release date: | 2017-03-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F. Sci Rep, 7, 2017
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5M29
| Structure of cobinamide-bound BtuF, the periplasmic vitamin B12 binding protein in E.coli | Descriptor: | COB(II)INAMIDE, CYANIDE ION, GLYCEROL, ... | Authors: | Mireku, S.A, Ruetz, M, Zhou, T, Korkhov, V.M, Kraeutler, B, Locher, K.P. | Deposit date: | 2016-10-12 | Release date: | 2017-02-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F. Sci Rep, 7, 2017
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5M3B
| Structure of cobinamide-bound BtuF mutant W66L, the periplasmic vitamin B12 binding protein in E.coli | Descriptor: | COB(II)INAMIDE, CYANIDE ION, GLYCEROL, ... | Authors: | Mireku, S.A, Ruetz, M, Zhou, T, Korkhov, V.M, Kraeutler, B, Locher, K.P. | Deposit date: | 2016-10-14 | Release date: | 2017-03-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F. Sci Rep, 7, 2017
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5M34
| Structure of cobinamide-bound BtuF mutant W66Y, the periplasmic vitamin B12 binding protein in E.coli | Descriptor: | COB(II)INAMIDE, CYANIDE ION, GLYCEROL, ... | Authors: | Mireku, S.A, Ruetz, M, Zhou, T, Korkhov, V.M, Kraeutler, B, Locher, K.P. | Deposit date: | 2016-10-14 | Release date: | 2017-03-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F. Sci Rep, 7, 2017
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