8FU6
| GCGR-Gs complex in the presence of RAMP2 | Descriptor: | Glucagon derivative ZP3780, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Krishna Kumar, K, O'Brien, E.S, Wang, H, Montabana, E, Kobilka, B.K. | Deposit date: | 2023-01-16 | Release date: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Negative allosteric modulation of the glucagon receptor by RAMP2. Cell, 186, 2023
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4JZG
| Crystal structure of a single cambialistic SOD2 occupied by Manganese ion from Clostridium difficile | Descriptor: | MANGANESE (II) ION, Superoxide dismutase | Authors: | Li, W, Wang, C.L, Zhao, Y, Wang, H.F, Tan, S.X. | Deposit date: | 2013-04-02 | Release date: | 2014-04-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.321 Å) | Cite: | Crystal structure of a single cambialistic SOD2 occupied by Manganese ion from Clostridium difficile To be Published
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4JZ2
| Crystal structure of Co ion substituted SOD2 from Clostridium difficile | Descriptor: | COBALT (II) ION, Superoxide dismutase | Authors: | Li, W, Ying, T.L, Wang, C.L, Zhao, Y, Wang, H.F, Tan, X.S. | Deposit date: | 2013-04-02 | Release date: | 2014-04-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of Co ion substituted SOD2 from Clostridium difficile To be Published
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5GW4
| Structure of Yeast NPP-TRiC | Descriptor: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | Authors: | Zang, Y, Jin, M, Wang, H, Cong, Y. | Deposit date: | 2016-09-08 | Release date: | 2016-10-26 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM. Nat. Struct. Mol. Biol., 23, 2016
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4QBE
| The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop | Descriptor: | Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X. | Deposit date: | 2014-05-08 | Release date: | 2014-12-24 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.292 Å) | Cite: | The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C, 2014
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5GW5
| Structure of TRiC-AMP-PNP | Descriptor: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | Authors: | Zang, Y, Jin, M, Wang, H, Cong, Y. | Deposit date: | 2016-09-08 | Release date: | 2016-10-26 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM. Nat. Struct. Mol. Biol., 23, 2016
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4QBW
| The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. | Deposit date: | 2014-05-08 | Release date: | 2015-02-11 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.912 Å) | Cite: | The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014
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4JYY
| Crystal structure of the azide and iron substituted Clostrium difficile SOD2 complex | Descriptor: | AZIDE ION, FE (III) ION, Superoxide dismutase | Authors: | Li, W, Ying, T.L, Wang, C.L, Zhao, Y, Wang, H.F, Tan, X.S. | Deposit date: | 2013-04-01 | Release date: | 2014-04-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | Crystal structure of the azide and iron substituted Clostrium difficile SOD2 complex To be Published
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8G9D
| Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 5- phosphonodifluoroacetamide inositol pentakisphosphate (5-PCF2Am-InsP5), an analogue of 5-InsP7 | Descriptor: | (1,1-difluoro-2-oxo-2-{[(1s,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]amino}ethyl)phosphonic acid, Diphosphoinositol polyphosphate phosphohydrolase 1 | Authors: | Zong, G, Wang, H, Shears, S. | Deposit date: | 2023-02-21 | Release date: | 2024-01-03 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs. Chemistry, 29, 2023
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5WH6
| Crystal structure of PDE4D2 in complex with inhibitor (S_Zl-n-91) | Descriptor: | 1-[4-(difluoromethoxy)-3-{[(3S)-oxolan-3-yl]oxy}phenyl]-3-methylbutan-1-one, MAGNESIUM ION, ZINC ION, ... | Authors: | Ke, H, Wang, H. | Deposit date: | 2017-07-14 | Release date: | 2018-07-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Identification of a PDE4-Specific Pocket for the Design of Selective Inhibitors. Biochemistry, 57, 2018
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4KUI
| Crystal structure of N-terminal acetylated yeast Sir3 BAH domain | Descriptor: | ACETIC ACID, ISOPROPYL ALCOHOL, Regulatory protein SIR3 | Authors: | Yang, D, Fang, Q, Wang, M, Ren, R, Wang, H, He, M, Sun, Y, Yang, N, Xu, R.M. | Deposit date: | 2013-05-22 | Release date: | 2013-08-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | N alpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat.Struct.Mol.Biol., 20, 2013
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5DJT
| Crystal structure of LOV2 (C450A) domain in complex with Zdk2 | Descriptor: | CHLORIDE ION, COPPER (II) ION, Engineered protein, ... | Authors: | Tarnawski, M, Wang, H, Yumerefendi, H, Hahn, K.M, Schlichting, I. | Deposit date: | 2015-09-02 | Release date: | 2016-07-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | LOVTRAP: an optogenetic system for photoinduced protein dissociation. Nat.Methods, 13, 2016
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7W0A
| dmDicer2-LoqsPD-dsRNA Dimer status | Descriptor: | Dicer-2, isoform A, Loquacious, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
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2Z8N
| Structural basis for the catalytic mechanism of phosphothreonine lyase | Descriptor: | 27.5 kDa virulence protein, SULFATE ION | Authors: | Chen, L, Wang, H, Gu, L, Huang, N, Zhou, J.M, Chai, J. | Deposit date: | 2007-09-07 | Release date: | 2007-12-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for the catalytic mechanism of phosphothreonine lyase. Nat.Struct.Mol.Biol., 15, 2008
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4QAP
| The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. | Deposit date: | 2014-05-05 | Release date: | 2015-02-11 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.903 Å) | Cite: | The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014
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4QAH
| The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Bi, W.X. | Deposit date: | 2014-05-05 | Release date: | 2014-12-24 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.403 Å) | Cite: | The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C, 2014
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4KUL
| Crystal structure of N-terminal acetylated yeast Sir3 BAH domain V83P mutant | Descriptor: | Regulatory protein SIR3 | Authors: | Yang, D, Fang, Q, Wang, M, Ren, R, Wang, H, He, M, Sun, Y, Yang, N, Xu, R.M. | Deposit date: | 2013-05-22 | Release date: | 2013-08-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | N alpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat.Struct.Mol.Biol., 20, 2013
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3LML
| Crystal Structure of the sheath tail protein Lin1278 from Listeria innocua, Northeast Structural Genomics Consortium Target LkR115 | Descriptor: | Lin1278 protein | Authors: | Forouhar, F, Neely, H, Seetharaman, J, Mao, M, Xiao, R, Patel, D.J, Ciccosanti, C, Wang, H, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-01-31 | Release date: | 2010-03-09 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Northeast Structural Genomics Consortium Target LkR115 To be Published
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2LDU
| Solution NMR Structure of Heat shock factor protein 1 DNA binding domain from homo sapiens, Northeast Structural Genomics Consortium Target HR3023C | Descriptor: | Heat shock factor protein 1 | Authors: | Liu, G, Xiao, R, Ciccosanti, C, Janjua, H, Acton, T.B, Lee, H, Wang, H.B, Huang, Y.B, Everett, J.K, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2011-06-01 | Release date: | 2011-07-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Northeast Structural Genomics Consortium Target HR3023C To be Published
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6J5W
| Ligand-triggered allosteric ADP release primes a plant NLR complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Disease resistance RPP13-like protein 4, RKS1 | Authors: | Wang, J.Z, Wang, J, Hu, M.J, Wang, H.W, Zhou, J.M, Chai, J.J. | Deposit date: | 2019-01-12 | Release date: | 2019-04-03 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Ligand-triggered allosteric ADP release primes a plant NLR complex. Science, 364, 2019
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6J5V
| Ligand-triggered allosteric ADP release primes a plant NLR complex | Descriptor: | Disease resistance RPP13-like protein 4, Probable serine/threonine-protein kinase PBL2, Protein kinase superfamily protein, ... | Authors: | Wang, J.Z, Wang, J, Hu, M.J, Wang, H.W, Zhou, J.M, Chai, J.J. | Deposit date: | 2019-01-12 | Release date: | 2019-04-03 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (4.25 Å) | Cite: | Ligand-triggered allosteric ADP release primes a plant NLR complex. Science, 364, 2019
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1CKR
| HIGH RESOLUTION SOLUTION STRUCTURE OF THE HEAT SHOCK COGNATE-70 KD SUBSTRATE BINDING DOMAIN OBTAINED BY MULTIDIMENSIONAL NMR TECHNIQUES | Descriptor: | HEAT SHOCK SUBSTRATE BINDING DOMAIN OF HSC-70 | Authors: | Morshauser, R.C, Hu, W, Wang, H, Pang, Y, Flynn, G.C, Zuiderweg, E.R.P. | Deposit date: | 1999-04-22 | Release date: | 1999-04-30 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | High-resolution solution structure of the 18 kDa substrate-binding domain of the mammalian chaperone protein Hsc70. J.Mol.Biol., 289, 1999
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1Q2F
| NMR SOLUTION STRUCTURE OF A PEPTIDE FROM THE MDM-2 BINDING DOMAIN OF THE P53 PROTEIN THAT IS SELECTIVELY CYTOTOXIC TO CANCER CELLS | Descriptor: | PNC27 | Authors: | Rosal, R, Pincus, M.R, Brandt-Rauf, P.W, Fine, R.L, Wang, H. | Deposit date: | 2003-07-24 | Release date: | 2004-03-16 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | NMR solution structure of a peptide from the mdm-2 binding domain of the p53 protein that is selectively cytotoxic to cancer cells Biochemistry, 43, 2004
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3CEW
| Crystal structure of a cupin protein (BF4112) from Bacteroides fragilis. Northeast Structural Genomics Consortium target BfR205 | Descriptor: | Uncharacterized cupin protein, ZINC ION | Authors: | Forouhar, F, Chen, Y, Seetharaman, J, Mao, L, Xiao, R, Ciccosanti, C, Foote, E.L, Maglaqui, M, Wang, H, Baran, M.C, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-02-29 | Release date: | 2008-03-25 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Crystal structure of a cupin protein (BF4112) from Bacteroides fragilis. Northeast Structural Genomics Consortium target BfR205. To be Published
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2ZM6
| Crystal structure of the Thermus thermophilus 30S ribosomal subunit | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Kaminishi, T, Wang, H, Kawazoe, M, Ishii, R, Schluenzen, F, Hanawa-Suetsugu, K, Wilson, D.N, Nomura, M, Takemoto, C, Shirouzu, M, Fucini, P, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2008-04-11 | Release date: | 2009-04-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Crystal structure of the Thermus thermophilus 30S ribosomal subunit To be Published
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