3JCM
 
 | | Cryo-EM structure of the spliceosomal U4/U6.U5 tri-snRNP | | Descriptor: | 13 kDa ribonucleoprotein-associated protein, GUANOSINE-5'-TRIPHOSPHATE, N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate), ... | | Authors: | Wan, R, Yan, C, Bai, R, Wang, L, Huang, M, Wong, C.C, Shi, Y. | | Deposit date: | 2015-12-23 | | Release date: | 2016-02-24 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | The 3.8 angstrom structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis
Science, 351, 2016
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5YLZ
 | | Cryo-EM Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae at 3.6 angstrom | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Wan, R, Yan, C, Bai, R, Lei, J, Shi, Y. | | Deposit date: | 2017-10-20 | | Release date: | 2018-07-18 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae
Cell, 171, 2017
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5Y88
 | | Cryo-EM structure of the intron-lariat spliceosome ready for disassembly from S.cerevisiae at 3.5 angstrom | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Intron lariat, ... | | Authors: | Wan, R, Yan, C, Bai, R, Lei, J, Shi, Y. | | Deposit date: | 2017-08-20 | | Release date: | 2018-08-01 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae
Cell(Cambridge,Mass.), 171, 2017
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5GMK
 | | Cryo-EM structure of the Catalytic Step I spliceosome (C complex) at 3.4 angstrom resolution | | Descriptor: | 5'-Exon, 5'-Splicing Site, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Wan, R, Yan, C, Bai, R, Huang, G, Shi, Y. | | Deposit date: | 2016-07-14 | | Release date: | 2016-08-17 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure of a yeast catalytic step I spliceosome at 3.4 angstrom resolution
Science, 353, 2016
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6J6G
 | | Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom | | Descriptor: | ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | | Deposit date: | 2019-01-15 | | Release date: | 2019-04-24 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell, 177, 2019
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6J6H
 | | Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom | | Descriptor: | ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | | Deposit date: | 2019-01-15 | | Release date: | 2019-04-24 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell, 177, 2019
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6J6N
 | | Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | | Deposit date: | 2019-01-15 | | Release date: | 2019-04-24 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (3.86 Å) | | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell, 177, 2019
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6J6Q
 | | Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | | Deposit date: | 2019-01-15 | | Release date: | 2019-04-24 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell, 177, 2019
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5KKN
 | | Crystal structure of human ACC2 BC domain in complex with ND-646, the primary amide of ND-630 | | Descriptor: | 2-[1-[(2~{R})-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-bis(oxidanylidene)thieno[2,3-d]pyrimidin-3-yl]-2-methyl-propanamide, Acetyl-CoA carboxylase 2 | | Authors: | Wang, R, Paul, D, Tong, L. | | Deposit date: | 2016-06-22 | | Release date: | 2016-07-13 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
Proc.Natl.Acad.Sci.USA, 113, 2016
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8BB7
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8B3K
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7QVK
 | | NM-02 in complex with HER2-ECD | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, NM-02, Receptor tyrosine-protein kinase erbB-2, ... | | Authors: | Cowan, R, Hall, G, Carr, M. | | Deposit date: | 2022-01-21 | | Release date: | 2023-02-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Co-crystallisation and humanisation of an anti-HER2 single-domain antibody as a theranostic tool.
Plos One, 18, 2023
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4U32
 | | Human mesotrypsin complexed with HAI-2 Kunitz domain 1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Kunitz-type protease inhibitor 2, ... | | Authors: | Wang, R, Soares, A.S, Radisky, E.S. | | Deposit date: | 2014-07-18 | | Release date: | 2014-10-15 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN.
J.Biol.Chem., 289, 2014
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4U30
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4WVD
 | | Identification of a novel FXR ligand that regulates metabolism | | Descriptor: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, Bile acid receptor, FORMIC ACID, ... | | Authors: | Wang, R, Li, Y. | | Deposit date: | 2014-11-05 | | Release date: | 2015-02-11 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism.
Nat Commun, 4, 2013
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8ILM
 | | The cryo-EM structure of eight Rubisco large subunits (RbcL), two Arabidopsis thaliana Rubisco accumulation factors 1 (AtRaf1), and seven Arabidopsis thaliana Bundle Sheath Defective 2 (AtBSD2) | | Descriptor: | Protein BUNDLE SHEATH DEFECTIVE 2, chloroplastic, Ribulose bisphosphate carboxylase large chain, ... | | Authors: | Wang, R, Song, H, Zhang, W, Wang, N, Zhang, S, Shao, R. | | Deposit date: | 2023-03-03 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural insights into the functions of Raf1 and Bsd2 in hexadecameric Rubisco assembly.
Mol Plant, 16, 2023
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8IO2
 | | The Rubisco assembly intermidate of Arabidopsis thaliana Rubisco accumulation factor 1 (AtRaf1) and Rubisco large subunit (RbcL) | | Descriptor: | Ribulose bisphosphate carboxylase large chain, Rubisco accumulation factor 1.2, chloroplastic | | Authors: | Wang, R, Song, H, Zhang, W, Wang, N, Zhang, S, Shao, R. | | Deposit date: | 2023-03-10 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insights into the functions of Raf1 and Bsd2 in hexadecameric Rubisco assembly.
Mol Plant, 16, 2023
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8IOJ
 | | The Rubisco assembly intermidiate of Rubisco large subunit (RbcL) and Arabidopsis thaliana Rubisco accumulation factor 1 (AtRaf1) | | Descriptor: | Ribulose bisphosphate carboxylase large chain, Rubisco accumulation factor 1.2, chloroplastic | | Authors: | Wang, R, Song, H, Zhang, W, Wang, N, Zhang, S, Shao, R. | | Deposit date: | 2023-03-11 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural insights into the functions of Raf1 and Bsd2 in hexadecameric Rubisco assembly.
Mol Plant, 16, 2023
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8ILB
 | | The complexes of RbcL, AtRaf1 and AtBSD2 (LFB) | | Descriptor: | Protein BUNDLE SHEATH DEFECTIVE 2, chloroplastic, Ribulose bisphosphate carboxylase large chain, ... | | Authors: | Wang, R, Song, H, Zhang, W, Wang, N, Zhang, S, Shao, R. | | Deposit date: | 2023-03-03 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural insights into the functions of Raf1 and Bsd2 in hexadecameric Rubisco assembly.
Mol Plant, 16, 2023
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8IOL
 | | The complex of Rubisco large subunit (RbcL) | | Descriptor: | Ribulose bisphosphate carboxylase large chain | | Authors: | Wang, R, Song, H, Zhang, W, Wang, N, Zhang, S, Shao, R. | | Deposit date: | 2023-03-11 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural insights into the functions of Raf1 and Bsd2 in hexadecameric Rubisco assembly.
Mol Plant, 16, 2023
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6XBY
 | | Cryo-EM structure of V-ATPase from bovine brain, state 2 | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Wang, R, Li, X. | | Deposit date: | 2020-06-07 | | Release date: | 2020-08-19 | | Method: | ELECTRON MICROSCOPY (3.79 Å) | | Cite: | Cryo-EM structures of intact V-ATPase from bovine brain.
Nat Commun, 11, 2020
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6XBW
 | | Cryo-EM structure of V-ATPase from bovine brain, state 1 | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Wang, R, Li, X. | | Deposit date: | 2020-06-07 | | Release date: | 2020-08-19 | | Method: | ELECTRON MICROSCOPY (3.37 Å) | | Cite: | Cryo-EM structures of intact V-ATPase from bovine brain.
Nat Commun, 11, 2020
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5J5C
 | | Crystal structure of ARL1-GTP and DCB domain of BIG1 complex | | Descriptor: | ADP-ribosylation factor-like protein 1, Brefeldin A-inhibited guanine nucleotide-exchange protein 1, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Wang, R, Wang, Z, Zhang, T, Ding, J. | | Deposit date: | 2016-04-02 | | Release date: | 2016-09-28 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1
J Mol Cell Biol, 2016
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4Y29
 | | Identification of a novel PPARg ligand that regulates metabolism | | Descriptor: | 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium, Peptide from Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma | | Authors: | Wang, R, Li, Y. | | Deposit date: | 2015-02-09 | | Release date: | 2015-09-09 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Selective targeting of PPAR gamma by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency.
Sci Rep, 5, 2015
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5JHG
 | | Crystal structure of the complex between the human RhoA and the DH/PH domain of human ARHGEF11 | | Descriptor: | GLYCEROL, Rho guanine nucleotide exchange factor 11, Transforming protein RhoA | | Authors: | Wang, R, Chen, Q, Zhang, H, Yan, Z, Li, J, Miao, L, Wang, F. | | Deposit date: | 2016-04-21 | | Release date: | 2017-04-26 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and ARHGEF11
To Be Published
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