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4U30

Human mesotrypsin complexed with bikunin Kunitz domain 2

Summary for 4U30
Entry DOI10.2210/pdb4u30/pdb
Related4U32
DescriptorTrypsin-3, Trypstatin, CALCIUM ION, ... (4 entities in total)
Functional Keywordsserine protease, protease inhibitor, protein-protein interaction, protein degradation, proteolysis, substrate specificity, enzyme kinetics, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
More
Cellular locationSecreted: P35030 P02760
Total number of polymer chains8
Total formula weight123008.17
Authors
Wang, R.,Soares, A.S.,Radisky, E.S. (deposition date: 2014-07-18, release date: 2014-10-15, Last modification date: 2023-12-27)
Primary citationPendlebury, D.,Wang, R.,Henin, R.D.,Hockla, A.,Soares, A.S.,Madden, B.J.,Kazanov, M.D.,Radisky, E.S.
Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN.
J.Biol.Chem., 289:32783-32797, 2014
Cited by
PubMed: 25301953
DOI: 10.1074/jbc.M114.609560
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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