4WVD

Identification of a novel FXR ligand that regulates metabolism

Replaces:  4II6

Summary for 4WVD

• Entry DOI: 10.2210/pdb4wvd/pdb
• Descriptor: Nuclear receptor corepressor 1, Bile acid receptor, FORMIC ACID, ... (5 entities in total)
• Functional Keywords: af-2 helix, ligand binding pocket, three-layer helical sandwich, transcription regulator fxr, bar, nr1h4, bile acid receptor, nhr, nuclear receptor, corepressor, transcription, transcription regulation
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : O75376; Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1
• Total number of polymer chains: 4
• Total formula weight: 55059.29

Authors

Wang, R.,Li, Y. (deposition date: 2014-11-05, release date: 2015-02-11, Last modification date: 2024-03-20)

• Primary citation: Jin, L.,Feng, X.,Rong, H.,Pan, Z.,Inaba, Y.,Qiu, L.,Zheng, W.,Lin, S.,Wang, R.,Wang, Z.,Wang, S.,Liu, H.,Li, S.,Xie, W.,Li, Y.; The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism.; Nat Commun, 4:1937-, 2013; PubMed: 23728580; DOI: 10.1038/ncomms2924

Experimental method

X-RAY DIFFRACTION (2.9 Å)