4U32

Human mesotrypsin complexed with HAI-2 Kunitz domain 1

Summary for 4U32

Entry DOI	10.2210/pdb4u32/pdb
Related	4U30
Descriptor	Kunitz-type protease inhibitor 2, Trypsin-3, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	serine protease, protease inhibitor, protein-protein interaction, protein degradation, proteolysis, substrate specificity, enzyme kinetics, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human) More
Cellular location	Membrane ; Single-pass type I membrane protein : O43291 Secreted: P35030
Total number of polymer chains	2
Total formula weight	30822.99
Authors	Wang, R.,Soares, A.S.,Radisky, E.S. (deposition date: 2014-07-18, release date: 2014-10-15, Last modification date: 2023-12-27)
Primary citation	Pendlebury, D.,Wang, R.,Henin, R.D.,Hockla, A.,Soares, A.S.,Madden, B.J.,Kazanov, M.D.,Radisky, E.S. Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN. J.Biol.Chem., 289:32783-32797, 2014 Cited by PubMed: 25301953 DOI: 10.1074/jbc.M114.609560 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation