Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 86 results

4RKY
DownloadVisualize
BU of 4rky by Molmil
Crystal structure of DJ-1 isoform X1
Descriptor: Protein DJ-1
Authors:Liddington, R.C.
Deposit date:2014-10-14
Release date:2015-08-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.
J.Neurosci., 34, 2014
4RKW
DownloadVisualize
BU of 4rkw by Molmil
Crystal structure of DJ-1
Descriptor: Protein DJ-1
Authors:Liddington, R.C.
Deposit date:2014-10-14
Release date:2015-08-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.
J.Neurosci., 34, 2014
7M1V
DownloadVisualize
BU of 7m1v by Molmil
Structure of Zika virus NS2b-NS3 protease mutant binding the compound NSC86314 in the super-open conformation
Descriptor: 1,2-ETHANEDIOL, 4-(2-{2,4-diamino-5-[2-(4-{[(2E)-1,3-thiazolidin-2-ylidene]sulfamoyl}phenyl)hydrazinyl]phenyl}hydrazinyl)-N-[(2S)-1,3-thiazolidin-2-yl]benzene-1-sulfonamide, CHLORIDE ION, ...
Authors:Aleshin, A.E, Shiryaev, S.A, Liddington, R.C.
Deposit date:2021-03-15
Release date:2021-04-21
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:To be provided
To Be Published
6UM3
DownloadVisualize
BU of 6um3 by Molmil
Structure of Zika virus NS2b-NS3 protease mutant stabilizing the super-open conformation
Descriptor: 1,2-ETHANEDIOL, NS2B-NS3 PROTEASE fusion
Authors:Aleshin, A.E, Shiryaev, S.A, Liddington, R.C.
Deposit date:2019-10-08
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Zika virus NS2b-NS3 protease mutant stabilizing the super-open conformation
To Be Published
1QKR
DownloadVisualize
BU of 1qkr by Molmil
Crystal structure of the vinculin tail and a pathway for activation
Descriptor: SULFATE ION, VINCULIN
Authors:Bakolitsa, C, De Pereda, J.M, Bagshaw, C.R, Critchley, D.R, Liddington, R.C.
Deposit date:1999-08-04
Release date:2000-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Vinculin Tail and a Pathway for Activation
Cell(Cambridge,Mass.), 99, 1999
2A25
DownloadVisualize
BU of 2a25 by Molmil
Crystal structure of Siah1 SBD bound to the peptide EKPAAVVAPITTG from SIP
Descriptor: Calcyclin-binding protein peptide, Ubiquitin ligase SIAH1, ZINC ION
Authors:Santelli, E, Leone, M, Li, C, Fukushima, T, Preece, N.E, Olson, A.J, Ely, K.R, Reed, J.C, Pellecchia, M, Liddington, R.C, Matsuzawa, S.
Deposit date:2005-06-21
Release date:2005-08-09
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Analysis of Siah1-Siah-interacting Protein Interactions and Insights into the Assembly of an E3 Ligase Multiprotein Complex
J.Biol.Chem., 280, 2005
2A26
DownloadVisualize
BU of 2a26 by Molmil
Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein
Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Calcyclin-binding protein, SULFATE ION
Authors:Santelli, E, Leone, M, Li, C, Fukushima, T, Preece, N.E, Olson, A.J, Ely, K.R, Reed, J.C, Pellecchia, M, Liddington, R.C, Matsuzawa, S.
Deposit date:2005-06-21
Release date:2005-08-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural Analysis of Siah1-Siah-interacting Protein Interactions and Insights into the Assembly of an E3 Ligase Multiprotein Complex
J.Biol.Chem., 280, 2005
6BDN
DownloadVisualize
BU of 6bdn by Molmil
Crystal structure of human TAO3 kinase binding ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Aleshin, A.E, Bankton, L.A, Pinkerton, A, Courtneidge, S.A, Liddington, R.C.
Deposit date:2017-10-23
Release date:2019-04-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of human TAO3 kinase binding ADP
To Be Published
3L4C
DownloadVisualize
BU of 3l4c by Molmil
Structural basis of membrane-targeting by Dock180
Descriptor: BETA-MERCAPTOETHANOL, Dedicator of cytokinesis protein 1
Authors:Premkumar, L, Bobkov, A.A, Patel, M, Jaroszewski, L, Bankston, L.A, Stec, B, Vuori, K, Cote, J.-F, Liddington, R.C.
Deposit date:2009-12-18
Release date:2010-02-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs).
J.Biol.Chem., 285, 2010
2AR3
DownloadVisualize
BU of 2ar3 by Molmil
E90A mutant structure of PlyL
Descriptor: PHOSPHATE ION, ZINC ION, prophage lambdaba02, ...
Authors:Low, L.Y, Yang, C, Perego, M, Osterman, A, Liddington, R.C.
Deposit date:2005-08-19
Release date:2006-06-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and lytic activity of a Bacillus anthracis prophage endolysin.
J.Biol.Chem., 280, 2005
4I7D
DownloadVisualize
BU of 4i7d by Molmil
Siah1 bound to synthetic peptide (ACE)KLRPVAMVRP(PRK)VR
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase SIAH1, Protein phyllopod, ...
Authors:Santelli, E, Stebbins, J.L, Feng, Y, De, S.K, Purves, A, Motamedchaboki, K, Wu, B, Ronai, Z.A, Liddington, R.C, Pellecchia, M.
Deposit date:2012-11-30
Release date:2013-08-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-based design of covalent siah inhibitors.
Chem.Biol., 20, 2013
7MHD
DownloadVisualize
BU of 7mhd by Molmil
Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7635
Descriptor: Fatty acid synthase, N,N-diethyl-4-{2-[(2-fluorophenyl)methyl]-1,3-thiazol-4-yl}benzene-1-sulfonamide
Authors:Aleshin, A.E, Lambert, L, Liddington, R.C, Cosford, N.
Deposit date:2021-04-15
Release date:2022-04-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7635
To Be Published
7MHE
DownloadVisualize
BU of 7mhe by Molmil
Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7957
Descriptor: 1,2-ETHANEDIOL, 4-{4-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]benzene-1-sulfonyl}morpholine, Fatty acid synthase
Authors:Aleshin, A.E, Lambert, L, Liddington, R.C, Cosford, N.
Deposit date:2021-04-15
Release date:2022-04-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7635
To Be Published
3T5O
DownloadVisualize
BU of 3t5o by Molmil
Crystal Structure of human Complement Component C6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, Complement component C6, ...
Authors:Aleshin, A.E, Stec, B, Bankston, L.A, DiScipio, R.G, Liddington, R.C.
Deposit date:2011-07-27
Release date:2012-02-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.869 Å)
Cite:Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC).
J.Biol.Chem., 287, 2012
5TFO
DownloadVisualize
BU of 5tfo by Molmil
CRYSTAL STRUCTURE OF THE ZIKA VIRUS NS2B-NS3 PROTEASE with a deletion V76-L86 in NS2b
Descriptor: NS2B-NS3 Protease CHIMERA,NS2B-NS3 PROTEASE,NS2B-NS3 Protease CHIMERA
Authors:Aleshin, A.E, Bankston, L, Liddington, R.C.
Deposit date:2016-09-26
Release date:2017-10-25
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:A novel conformation for the Zika virus NS2B-NS3 protease offers new insights into biological regulation and inhibitor design.
To Be Published
5TFN
DownloadVisualize
BU of 5tfn by Molmil
CRYSTAL STRUCTURE OF THE ZIKA VIRUS NS2B-NS3 PROTEASE in super-open conformation
Descriptor: NS2B-NS3 Protease CHIMERA,Genome polyprotein
Authors:Aleshin, A.E, Bankston, L, Liddington, R.C.
Deposit date:2016-09-26
Release date:2017-10-25
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3 Å)
Cite:A novel conformation for the Zika virus NS2B-NS3 protease offers new insights into biological regulation and inhibitor design.
To Be Published
5TBP
DownloadVisualize
BU of 5tbp by Molmil
Crystal Structure of RXR-alpha ligand binding domain complexed with synthetic modulator K8003
Descriptor: ACETATE ION, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Aleshin, A.E, Liddington, R.C, Su, Y, Zhang, X.
Deposit date:2016-09-12
Release date:2017-08-09
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha.
Nat Commun, 8, 2017
4ON1
DownloadVisualize
BU of 4on1 by Molmil
Crystal Structure of metalloproteinase-II from Bacteroides fragilis
Descriptor: GLYCEROL, Putative metalloprotease II, ZINC ION
Authors:Aleshin, A.E, Liddington, R.C, Shiryaev, S.A, Strongin, A.Y.
Deposit date:2014-01-28
Release date:2014-04-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island.
Febs J., 281, 2014
2M4N
DownloadVisualize
BU of 2m4n by Molmil
Solution structure of the putative Ras interaction domain of AFD-1, isoform a from Caenorhabditis elegans
Descriptor: Protein AFD-1, isoform a
Authors:Harris, R, Hillerich, B, Ahmed, M, Bonanno, J.B, Chamala, S, Evans, B, Lafleur, J, Hammonds, J, Washington, E, Stead, M, Love, J, Attonito, J, Seidel, R.D, Liddington, R.C, Weis, W.I, Nelson, W.J, Girvin, M.E, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Assembly, Dynamics and Evolution of Cell-Cell and Cell-Matrix Adhesions (CELLMAT)
Deposit date:2013-02-07
Release date:2013-03-20
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution structure of the putative Ras interaction domain of AFD-1, isoform a from Caenorhabditis elegans
To be Published
4N8R
DownloadVisualize
BU of 4n8r by Molmil
Crystal structure of RXRa LBD complexed with a synthetic modulator K-8008
Descriptor: 5-(2-{(1Z)-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha
Authors:Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C.
Deposit date:2013-10-17
Release date:2014-05-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site.
Chem.Biol., 21, 2014
4N5G
DownloadVisualize
BU of 4n5g by Molmil
Crystal Structure of RXRa LBD complexed with a synthetic modulator K8012
Descriptor: 5-(2-{(1Z)-5-fluoro-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha
Authors:Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C.
Deposit date:2013-10-09
Release date:2014-05-14
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site.
Chem.Biol., 21, 2014
2O3O
DownloadVisualize
BU of 2o3o by Molmil
Crystal Structure of the sensor histidine kinase regulator YycI from Bacillus subtitlis
Descriptor: CHLORIDE ION, YycI protein
Authors:Santelli, E, Liddington, R.C.
Deposit date:2006-12-01
Release date:2007-04-10
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:The Crystal Structure of Bacillus subtilis YycI Reveals a Common Fold for Two Members of an Unusual Class of Sensor Histidine Kinase Regulatory Proteins.
J.Bacteriol., 189, 2007
2OTN
DownloadVisualize
BU of 2otn by Molmil
Crystal structure of the catalytically active form of diaminopimelate epimerase from Bacillus anthracis
Descriptor: Diaminopimelate epimerase
Authors:Matho, M.H, Fukuda, K, Santelli, E, Jaroszewski, L, Liddington, R.C, Roper, D.
Deposit date:2007-02-08
Release date:2008-03-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure and inhibition of a catalytically active form of diaminopimelate epimerase (DapF)from Bacillus anthracis
To be Published
5JNU
DownloadVisualize
BU of 5jnu by Molmil
Crystal structure of mouse Low-Molecular Weight Protein Tyrosine Phosphatase type A (LMPTP-A) complexed with phosphate
Descriptor: Low molecular weight phosphotyrosine protein phosphatase, PHOSPHATE ION
Authors:Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N.
Deposit date:2016-04-30
Release date:2017-03-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.535 Å)
Cite:Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat. Chem. Biol., 13, 2017
5JNW
DownloadVisualize
BU of 5jnw by Molmil
Crystal structure of bovine low molecular weight protein tyrosine phosphatase (LMPTP) mutant (W49Y N50E) complexed with vanadate and uncompetitive inhibitor
Descriptor: 2-(4-{[3-(piperidin-1-yl)propyl]amino}quinolin-2-yl)benzonitrile, Low molecular weight phosphotyrosine protein phosphatase, VANADATE ION
Authors:Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N.
Deposit date:2016-04-30
Release date:2017-03-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat. Chem. Biol., 13, 2017

 

1234>

226707

PDB entries from 2024-10-30

PDB statisticsPDBj update infoContact PDBjnumon