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5TBP

Crystal Structure of RXR-alpha ligand binding domain complexed with synthetic modulator K8003

Summary for 5TBP
Entry DOI10.2210/pdb5tbp/pdb
DescriptorRetinoic acid receptor RXR-alpha, [(1Z)-5-fluoro-2-methyl-1-{[4-(propan-2-yl)phenyl]methylidene}-1H-inden-3-yl]acetic acid, ACETATE ION, ... (6 entities in total)
Functional Keywordsnuclear receptor, sulindac, akt activation, complex, tetramer, transcription, rxr, lbd
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight111772.08
Authors
Aleshin, A.E.,Liddington, R.C.,Su, Y.,Zhang, X. (deposition date: 2016-09-12, release date: 2017-08-09, Last modification date: 2023-10-04)
Primary citationChen, L.,Aleshin, A.E.,Alitongbieke, G.,Zhou, Y.,Zhang, X.,Ye, X.,Hu, M.,Ren, G.,Chen, Z.,Ma, Y.,Zhang, D.,Liu, S.,Gao, W.,Cai, L.,Wu, L.,Zeng, Z.,Jiang, F.,Liu, J.,Zhou, H.,Cadwell, G.,Liddington, R.C.,Su, Y.,Zhang, X.K.
Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha.
Nat Commun, 8:16066-16066, 2017
Cited by
PubMed: 28714476
DOI: 10.1038/ncomms16066
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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