5TBP
Crystal Structure of RXR-alpha ligand binding domain complexed with synthetic modulator K8003
Summary for 5TBP
Entry DOI | 10.2210/pdb5tbp/pdb |
Descriptor | Retinoic acid receptor RXR-alpha, [(1Z)-5-fluoro-2-methyl-1-{[4-(propan-2-yl)phenyl]methylidene}-1H-inden-3-yl]acetic acid, ACETATE ION, ... (6 entities in total) |
Functional Keywords | nuclear receptor, sulindac, akt activation, complex, tetramer, transcription, rxr, lbd |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 111772.08 |
Authors | Aleshin, A.E.,Liddington, R.C.,Su, Y.,Zhang, X. (deposition date: 2016-09-12, release date: 2017-08-09, Last modification date: 2023-10-04) |
Primary citation | Chen, L.,Aleshin, A.E.,Alitongbieke, G.,Zhou, Y.,Zhang, X.,Ye, X.,Hu, M.,Ren, G.,Chen, Z.,Ma, Y.,Zhang, D.,Liu, S.,Gao, W.,Cai, L.,Wu, L.,Zeng, Z.,Jiang, F.,Liu, J.,Zhou, H.,Cadwell, G.,Liddington, R.C.,Su, Y.,Zhang, X.K. Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha. Nat Commun, 8:16066-16066, 2017 Cited by PubMed: 28714476DOI: 10.1038/ncomms16066 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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