3T5O

Crystal Structure of human Complement Component C6

Summary for 3T5O

• Entry DOI: 10.2210/pdb3t5o/pdb
• Descriptor: Complement component C6, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose, ... (6 entities in total)
• Functional Keywords: macpf, mac, membrane attack complex, complement, innate immune system, blood, membrane, c7, c8, c9, cytolysin, immune system
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P13671
• Total number of polymer chains: 1
• Total formula weight: 104289.20

Authors

Aleshin, A.E.,Stec, B.,Bankston, L.A.,DiScipio, R.G.,Liddington, R.C. (deposition date: 2011-07-27, release date: 2012-02-01, Last modification date: 2020-07-29)

• Primary citation: Aleshin, A.E.,Schraufstatter, I.U.,Stec, B.,Bankston, L.A.,Liddington, R.C.,Discipio, R.G.; Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC).; J.Biol.Chem., 287:10210-10222, 2012; PubMed: 22267737; DOI: 10.1074/jbc.M111.327809

Experimental method

X-RAY DIFFRACTION (2.869 Å)