6NWP
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![BU of 6nwp by Molmil](/molmil-images/mine/6nwp) | Chronic traumatic encephalopathy Type I Tau filament | Descriptor: | Microtubule-associated protein tau | Authors: | Falcon, B, Zivanov, J, Zhang, W, Murzin, A.G, Garringer, H.J, Vidal, R, Crowther, R.A, Newell, K.L, Ghetti, B, Goedert, M, Scheres, H.W. | Deposit date: | 2019-02-07 | Release date: | 2019-03-27 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature, 568, 2019
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6NWQ
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![BU of 6nwq by Molmil](/molmil-images/mine/6nwq) | Chronic traumatic encephalopathy Type II Tau filament | Descriptor: | Microtubule-associated protein tau | Authors: | Falcon, B, Zivanov, J, Zhang, W, Murzin, A.G, Garringer, H.J, Vidal, R, Crowther, R.A, Newell, K.L, Ghetti, B, Goedert, M, Scheres, H.W. | Deposit date: | 2019-02-07 | Release date: | 2019-03-27 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature, 568, 2019
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6GX5
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![BU of 6gx5 by Molmil](/molmil-images/mine/6gx5) | Narrow Pick Filament from Pick's disease brain | Descriptor: | Microtubule-associated protein tau | Authors: | Falcon, B, Zhang, W, Murzin, A.G, Murshudov, G, Garringer, H.J, Vidal, R, Crowther, R.A, Ghetti, B, Scheres, S.H.W, Goedert, M. | Deposit date: | 2018-06-26 | Release date: | 2018-09-12 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of filaments from Pick's disease reveal a novel tau protein fold. Nature, 561, 2018
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6HRF
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![BU of 6hrf by Molmil](/molmil-images/mine/6hrf) | Straight filament from sporadic Alzheimer's disease brain | Descriptor: | Microtubule-associated protein tau | Authors: | Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M. | Deposit date: | 2018-09-26 | Release date: | 2018-10-10 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold. Acta Neuropathol., 136, 2018
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6HRE
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![BU of 6hre by Molmil](/molmil-images/mine/6hre) | Paired helical filament from sporadic Alzheimer's disease brain | Descriptor: | Microtubule-associated protein tau | Authors: | Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M. | Deposit date: | 2018-09-26 | Release date: | 2018-10-10 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold. Acta Neuropathol., 136, 2018
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1NLM
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![BU of 1nlm by Molmil](/molmil-images/mine/1nlm) | CRYSTAL STRUCTURE OF MURG:GLCNAC COMPLEX | Descriptor: | GLYCEROL, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE | Authors: | Hu, Y, Chen, L, Ha, S, Gross, B, Falcone, B, Walker, D, Mokhtarzadeh, M, Walker, S. | Deposit date: | 2003-01-07 | Release date: | 2003-02-11 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases Proc.Natl.Acad.Sci.USA, 100, 2003
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8CGH
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![BU of 8cgh by Molmil](/molmil-images/mine/8cgh) | |
8CG3
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![BU of 8cg3 by Molmil](/molmil-images/mine/8cg3) | |
8CGG
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![BU of 8cgg by Molmil](/molmil-images/mine/8cgg) | |
7Q4B
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![BU of 7q4b by Molmil](/molmil-images/mine/7q4b) | Type I beta-amyloid 42 Filaments from Human Brain | Descriptor: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | Authors: | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | Deposit date: | 2021-10-30 | Release date: | 2021-11-24 | Last modified: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Cryo-EM structures of amyloid-beta 42 filaments from human brains. Science, 375, 2022
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7Q4M
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![BU of 7q4m by Molmil](/molmil-images/mine/7q4m) | Type II beta-amyloid 42 Filaments from Human Brain | Descriptor: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | Authors: | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | Deposit date: | 2021-11-01 | Release date: | 2021-11-24 | Last modified: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structures of amyloid-beta 42 filaments from human brains. Science, 375, 2022
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7P6A
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![BU of 7p6a by Molmil](/molmil-images/mine/7p6a) | Limbic-predominant neuronal inclusion body 4R tauopathy type 1a tau filament | Descriptor: | Microtubule-associated protein tau | Authors: | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | Deposit date: | 2021-07-15 | Release date: | 2021-09-15 | Last modified: | 2021-10-27 | Method: | ELECTRON MICROSCOPY (1.9 Å) | Cite: | Structure-based classification of tauopathies. Nature, 598, 2021
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7P6B
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![BU of 7p6b by Molmil](/molmil-images/mine/7p6b) | Limbic-predominant neuronal inclusion body 4R tauopathy type 1b tau filament | Descriptor: | Microtubule-associated protein tau | Authors: | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | Deposit date: | 2021-07-15 | Release date: | 2021-09-15 | Last modified: | 2021-10-27 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Structure-based classification of tauopathies. Nature, 598, 2021
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7P6C
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![BU of 7p6c by Molmil](/molmil-images/mine/7p6c) | Limbic-predominant neuronal inclusion body 4R tauopathy type 2 tau filament | Descriptor: | Microtubule-associated protein tau | Authors: | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | Deposit date: | 2021-07-15 | Release date: | 2021-09-15 | Last modified: | 2021-10-27 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structure-based classification of tauopathies. Nature, 598, 2021
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7PY2
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![BU of 7py2 by Molmil](/molmil-images/mine/7py2) | Structure of pathological TDP-43 filaments from ALS with FTLD | Descriptor: | TAR DNA-binding protein 43 | Authors: | Arseni, D, Hasegawa, H, Murzin, A.G, Kametani, F, Arai, M, Yoshida, M, Falcon, B. | Deposit date: | 2021-10-08 | Release date: | 2021-12-15 | Last modified: | 2022-01-19 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structure of pathological TDP-43 filaments from ALS with FTLD. Nature, 601, 2022
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7P66
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![BU of 7p66 by Molmil](/molmil-images/mine/7p66) | Globular glial tauopathy type 1 tau filament | Descriptor: | Microtubule-associated protein tau | Authors: | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | Deposit date: | 2021-07-15 | Release date: | 2021-09-15 | Last modified: | 2021-10-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure-based classification of tauopathies. Nature, 598, 2021
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7P67
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![BU of 7p67 by Molmil](/molmil-images/mine/7p67) | Globular glial tauopathy type 2 tau filament | Descriptor: | Microtubule-associated protein tau | Authors: | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | Deposit date: | 2021-07-15 | Release date: | 2021-09-15 | Last modified: | 2021-10-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure-based classification of tauopathies. Nature, 598, 2021
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7P6E
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![BU of 7p6e by Molmil](/molmil-images/mine/7p6e) | Argyrophilic grain disease type 2 tau filament | Descriptor: | Microtubule-associated protein tau | Authors: | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | Deposit date: | 2021-07-15 | Release date: | 2021-09-15 | Last modified: | 2021-10-27 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure-based classification of tauopathies. Nature, 598, 2021
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7P6D
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![BU of 7p6d by Molmil](/molmil-images/mine/7p6d) | Argyrophilic grain disease type 1 tau filament | Descriptor: | Microtubule-associated protein tau | Authors: | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | Deposit date: | 2021-07-15 | Release date: | 2021-09-15 | Last modified: | 2021-10-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure-based classification of tauopathies. Nature, 598, 2021
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7P68
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![BU of 7p68 by Molmil](/molmil-images/mine/7p68) | Globular glial tauopathy type 3 tau filament | Descriptor: | Microtubule-associated protein tau | Authors: | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | Deposit date: | 2021-07-15 | Release date: | 2021-09-15 | Last modified: | 2021-10-27 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure-based classification of tauopathies. Nature, 598, 2021
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7P65
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![BU of 7p65 by Molmil](/molmil-images/mine/7p65) | Progressive supranuclear palsy tau filament | Descriptor: | Microtubule-associated protein tau | Authors: | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | Deposit date: | 2021-07-15 | Release date: | 2021-09-15 | Last modified: | 2021-10-27 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structure-based classification of tauopathies. Nature, 598, 2021
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5O3L
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![BU of 5o3l by Molmil](/molmil-images/mine/5o3l) | Paired helical filament in Alzheimer's disease brain | Descriptor: | Microtubule-associated protein tau | Authors: | Fitzpatrick, A.W.P, Falcon, B, He, S, Murzin, A.G, Murshudov, G, Garringer, H.G, Crowther, R.A, Ghetti, B, Goedert, M, Scheres, S.H.W. | Deposit date: | 2017-05-24 | Release date: | 2017-07-26 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease. Nature, 547, 2017
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5O3O
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![BU of 5o3o by Molmil](/molmil-images/mine/5o3o) | Pronase-treated paired helical filament in Alzheimer's disease brain | Descriptor: | Microtubule-associated protein tau | Authors: | Fitzpatrick, A.W.P, Falcon, B, He, S, Murzin, A.G, Murshudov, G, Garringer, H.G, Crowther, R.A, Ghetti, B, Goedert, M, Scheres, S.H.W. | Deposit date: | 2017-05-24 | Release date: | 2017-07-26 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease. Nature, 547, 2017
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5O3T
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![BU of 5o3t by Molmil](/molmil-images/mine/5o3t) | Straight filament in Alzheimer's disease brain | Descriptor: | Microtubule-associated protein tau | Authors: | Fitzpatrick, A.W.P, Falcon, B, He, S, Murzin, A.G, Murshudov, G, Garringer, H.G, Crowther, R.A, Ghetti, B, Goedert, M, Scheres, S.H.W. | Deposit date: | 2017-05-24 | Release date: | 2017-07-26 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures of tau filaments from Alzheimer's disease. Nature, 547, 2017
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6QJP
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![BU of 6qjp by Molmil](/molmil-images/mine/6qjp) | Cryo-EM structure of heparin-induced 2N4R tau jagged filaments | Descriptor: | Microtubule-associated protein tau | Authors: | Zhang, W, Falcon, B, Murzin, A.G, Fan, J, Crowther, R.A, Goedert, M, Scheres, S.H.W. | Deposit date: | 2019-01-24 | Release date: | 2019-02-20 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. Elife, 8, 2019
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