2WKH
| Crystal structure of the acyl-enzyme OXA-10 K70C-Ampicillin at pH 7 | Descriptor: | (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, BETA-LACTAMASE OXA-10, SULFATE ION | Authors: | Vercheval, L, Bauvois, C, Kerff, F, Sauvage, E, Guiet, R, Charlier, P, Galleni, M. | Deposit date: | 2009-06-11 | Release date: | 2010-08-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.791 Å) | Cite: | Three Factors that Modulate the Activity of Class D Beta-Lactamases and Interfere with the Post-Translational Carboxylation of Lys70. Biochem.J., 432, 2010
|
|
2X02
| CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10 AT 1.35 A RESOLUTION | Descriptor: | BETA-LACTAMASE OXA-10, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Vercheval, L, Kerff, F, Sauvage, E, Herman, R, Galleni, M, Charlier, P. | Deposit date: | 2009-12-04 | Release date: | 2010-12-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Impact of the Carboxylated Lysine on the Acylation and Deacylation Step in Class D Beta-Lactamase To be Published
|
|
2ZC7
| |
1DXK
| |
5DPX
| 1,2,4-Triazole-3-thione compounds as inhibitors of L1, di-zinc metallo-beta-lactamases. | Descriptor: | 5-(2-methylphenyl)-3H-1,2,4-triazole-3-thione, Metallo-beta-lactamase L1 type 3, SULFATE ION, ... | Authors: | Nauton, L, Garau, G, Khan, R, Dideberg, O. | Deposit date: | 2015-09-14 | Release date: | 2017-01-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | 1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-beta-lactamases. ChemMedChem, 12, 2017
|
|
7PA5
| Complex between the beta-lactamase CMY-2 with an inhibitory nanobody | Descriptor: | Beta-lactamase, GLYCEROL, PHOSPHATE ION, ... | Authors: | Frederic Cawez, F.C, Frederic Kerff, F.K, Moreno Galleni, M.G, Raphael Herman, R.H. | Deposit date: | 2021-07-29 | Release date: | 2022-11-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.184 Å) | Cite: | Development of Nanobodies as Theranostic Agents against CMY-2-Like Class C beta-Lactamases. Antimicrob.Agents Chemother., 67, 2023
|
|
1X8I
| Crystal Structure of the Zinc Carbapenemase CphA in Complex with the Antibiotic Biapenem | Descriptor: | 5H-PYRAZOLO(1,2-A)(1,2,4)TRIAZOL-4-IUM, 6-((2-CARBOXY-6-(1-HYDROXYETHYL)-4-METHYL-7-OXO-1-AZABICYCLO(3.2.0)HEPT-2-EN-3-YL)THIO)-6,7-DIHYDRO-, HYDROXIDE, ... | Authors: | Garau, G, Dideberg, O. | Deposit date: | 2004-08-18 | Release date: | 2004-12-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A Metallo-beta-lactamase Enzyme in Action: Crystal Structures of the Monozinc Carbapenemase CphA and its Complex with Biapenem J.Mol.Biol., 345, 2005
|
|
1X8G
| |
1IYS
| Crystal Structure of Class A beta-Lactamase Toho-1 | Descriptor: | BETA-LACTAMASE TOHO-1, SULFATE ION | Authors: | Ibuka, A.S, Ishii, Y, Yamaguchi, K, Matsuzawa, H, Sakai, H. | Deposit date: | 2002-09-06 | Release date: | 2003-10-14 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal Structure of Extended-Spectrum beta-Lactamase Toho-1: Insights into the Molecular Mechanism for
Catalytic Reaction and Substrate Specificity Expansion Biochemistry, 42, 2003
|
|
1X8H
| |
6YRP
| Crystal Structure of the VIM-2 Acquired Metallo-beta-Lactamase in Complex with JMV-4690 (Cpd 31) | Descriptor: | 1,2-ETHANEDIOL, 2-[[[3-(5-methoxy-2-oxidanyl-phenyl)-5-sulfanylidene-1~{H}-1,2,4-triazol-4-yl]amino]methyl]benzoic acid, ACETATE ION, ... | Authors: | Docquier, J.D, Pozzi, C, De Luca, F, Benvenuti, M, Mangani, S. | Deposit date: | 2020-04-20 | Release date: | 2020-09-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | 4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-beta-lactamase inhibitors. Eur.J.Med.Chem., 208, 2020
|
|
2QDS
| |
3IOG
| Crystal structure of CphA N220G mutant with inhibitor 18 | Descriptor: | Beta-lactamase, GLYCEROL, SULFATE ION, ... | Authors: | Delbruck, H, Bebrone, C, Hoffmann, K.M.V. | Deposit date: | 2009-08-14 | Release date: | 2010-06-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-beta-lactamases J.Med.Chem., 53, 2010
|
|
3IOF
| Crystal structure of CphA N220G mutant with inhibitor 10a | Descriptor: | Beta-lactamase, GLYCEROL, SULFATE ION, ... | Authors: | Delbruck, H, Bebrone, C, Hoffmann, K.M.V. | Deposit date: | 2009-08-14 | Release date: | 2010-06-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-beta-lactamases J.Med.Chem., 53, 2010
|
|
6ZZ3
| RBcel1 cellulase variant Y201F with cellotriose covalently bound | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Endoglucanase, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Collet, L, Dutoit, R. | Deposit date: | 2020-08-03 | Release date: | 2021-07-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.095 Å) | Cite: | Glycoside hydrolase family 5: structural snapshots highlighting the involvement of two conserved residues in catalysis. Acta Crystallogr D Struct Biol, 77, 2021
|
|
1BVT
| METALLO-BETA-LACTAMASE FROM BACILLUS CEREUS 569/H/9 | Descriptor: | BICARBONATE ION, PROTEIN (BETA-LACTAMASE), ZINC ION | Authors: | Carfi, A, Duee, E, Dideberg, O. | Deposit date: | 1998-09-18 | Release date: | 1998-09-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | 1.85 A resolution structure of the zinc (II) beta-lactamase from Bacillus cereus. Acta Crystallogr.,Sect.D, 54, 1998
|
|
2QDT
| |
1BMC
| STRUCTURE OF A ZINC METALLO-BETA-LACTAMASE FROM BACILLUS CEREUS | Descriptor: | METALLO-BETA-LACTAMASE, ZINC ION | Authors: | Carfi, A, Pares, S, Duee, E, Dideberg, O. | Deposit date: | 1995-06-16 | Release date: | 1996-08-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold. EMBO J., 14, 1995
|
|
2GKL
| Crystal structure of the zinc carbapenemase CPHA in complex with the inhibitor pyridine-2,4-dicarboxylate | Descriptor: | Beta-lactamase, GLYCEROL, PYRIDINE-2,4-DICARBOXYLIC ACID, ... | Authors: | Garau, G, Dideberg, O. | Deposit date: | 2006-04-03 | Release date: | 2007-03-13 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Competitive Inhibitors of the CphA Metallo-{beta}-Lactamase from Aeromonas hydrophila Antimicrob.Agents Chemother., 51, 2007
|
|
7PP0
| Crystal structure of the VIM-2 acquired metallo-beta-Lactamase in complex with compound 28 (JMV-7038) | Descriptor: | 2-[2-[3-[3-(2-morpholin-4-ylethoxy)phenyl]-5-sulfanylidene-1H-1,2,4-triazol-4-yl]ethyl]benzoic acid, ACETATE ION, Metallo-beta-lactamase VIM-2-like protein, ... | Authors: | Tassone, G, Benvenuti, M, Verdirosa, F, Corsica, G, Chelini, G, De Luca, F, Docquier, J.D, Pozzi, C, Mangani, S. | Deposit date: | 2021-09-10 | Release date: | 2022-03-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | 1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-beta-Lactamase Inhibitors. Chemmedchem, 17, 2022
|
|
3F9O
| |
3FAI
| The Di Zinc Carbapenemase CphA N220G mutant | Descriptor: | Beta-lactamase, CHLORIDE ION, GLYCEROL, ... | Authors: | Delbruck, H, Hoffmann, K.M.V. | Deposit date: | 2008-11-17 | Release date: | 2009-09-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The structure of the dizinc subclass B2 metallo-beta-lactamase CphA reveals that the second inhibitory zinc ion binds in the histidine site Antimicrob.Agents Chemother., 53, 2009
|
|
3SW3
| |
3T9M
| |
3TSG
| Crystal structure of GES-14 | Descriptor: | Extended-spectrum beta-lactamase GES-14, GLYCEROL, IODIDE ION | Authors: | Delbruck, H, Hoffmann, K.M.V, Bebrone, C. | Deposit date: | 2011-09-13 | Release date: | 2012-09-26 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Kinetic and crystallographic studies of extended-spectrum GES-11, GES-12, and GES-14 beta-lactamases. Antimicrob.Agents Chemother., 56, 2012
|
|