1U0J
| Crystal Structure of AAV2 Rep40-ADP complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA replication protein | Authors: | James, J.A, Aggarwal, A.K, Linden, R.M, Escalante, C.R. | Deposit date: | 2004-07-13 | Release date: | 2004-08-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of adeno-associated virus type 2 Rep40-ADP complex: Insight into
nucleotide recognition and catalysis by superfamily 3 helicases Proc.Natl.Acad.Sci.USA, 101, 2004
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1S97
| DPO4 with GT mismatch | Descriptor: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*CP*TP*G)-3', 5'-D(*T*TP*CP*AP*GP*TP*AP*GP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3', ... | Authors: | Trincao, J, Johnson, R.E, Wolfle, W.T, Escalante, C.R, Prakash, S, Prakash, L, Aggarwal, A.K. | Deposit date: | 2004-02-03 | Release date: | 2004-04-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Dpo4 is hindered in extending a G.T mismatch by a reverse wobble Nat.Struct.Mol.Biol., 11, 2004
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1SDO
| Crystal Structure of Restriction Endonuclease BstYI | Descriptor: | BstYI | Authors: | Townson, S.A, Samuelson, J.C, Vanamee, E.S, Edwards, T.A, Escalante, C.R, Xu, S.Y, Aggarwal, A.K. | Deposit date: | 2004-02-13 | Release date: | 2004-05-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal Structure of BstYI at 1.85 A Resolution: A Thermophilic Restriction Endonuclease with Overlapping Specificities to BamHI and BglII J.Mol.Biol., 338, 2004
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4ZCF
| Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I | Descriptor: | ADENOSINE MONOPHOSPHATE, CALCIUM ION, DNA 20-mer AATCATAGTCTACTGCTGTA, ... | Authors: | Gupta, Y.K, Chan, S.H, Xu, S.Y, Aggarwal, A.K. | Deposit date: | 2015-04-15 | Release date: | 2015-07-29 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I. Nat Commun, 6, 2015
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1S9F
| DPO with AT matched | Descriptor: | 2',3'-DIDEOXYCYTOSINE-5'-DIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*CP*TP*A)-3', 5'-D(*T*TP*CP*AP*GP*TP*AP*GP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3', ... | Authors: | Trincao, J, Johnson, R.E, Wolfle, W.T, Escalante, C.R, Prakash, S, Prakash, L, Aggarwal, A.K. | Deposit date: | 2004-02-04 | Release date: | 2005-02-15 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Dpo4 is hindered in extending a G.T mismatch by a reverse wobble Nat.Struct.Mol.Biol., 11, 2004
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1T3N
| Structure of the catalytic core of DNA polymerase Iota in complex with DNA and dTTP | Descriptor: | MAGNESIUM ION, Primer DNA strand, THYMIDINE-5'-TRIPHOSPHATE, ... | Authors: | Nair, D.T, Johnson, R.E, Prakash, S, Prakash, L, Aggarwal, A.K. | Deposit date: | 2004-04-27 | Release date: | 2004-07-20 | Last modified: | 2018-04-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing. Nature, 430, 2004
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1S9H
| Crystal Structure of Adeno-associated virus Type 2 Rep40 | Descriptor: | Rep 40 protein | Authors: | James, J.A, Escalante, C.R, Yoon-Robarts, M, Edwards, T.A, Linden, R.M, Aggarwal, A.K. | Deposit date: | 2004-02-04 | Release date: | 2004-05-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of the SF3 Helicase from Adeno-Associated Virus Type 2 Structure, 11, 2003
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1VRR
| Crystal structure of the restriction endonuclease BstYI complex with DNA | Descriptor: | 5'-D(*TP*TP*AP*TP*AP*GP*AP*TP*CP*TP*AP*TP*AP*A)-3', BstYI | Authors: | Townson, S.A, Samuelson, J.C, Xu, S.Y, Aggarwal, A.K. | Deposit date: | 2005-06-02 | Release date: | 2005-06-07 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Implications for Switching Restriction Enzyme Specificities from the Structure of BstYI Bound to a BglII DNA Sequence. Structure, 13, 2005
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1T94
| Crystal structure of the catalytic core of human DNA polymerase kappa | Descriptor: | polymerase (DNA directed) kappa | Authors: | Uljon, S.N, Johnson, R.E, Edwards, T.A, Prakash, S, Prakash, L, Aggarwal, A.K. | Deposit date: | 2004-05-14 | Release date: | 2004-08-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the catalytic core of human DNA polymerase kappa. STRUCTURE, 12, 2004
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3G6V
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3G6Y
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3G6X
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4EEY
| Crystal structure of human DNA polymerase eta in ternary complex with a cisplatin DNA adduct | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*TP*GP*GP*TP*CP*TP*CP*CP*TP*CP*C)-3', 5'-D(*TP*GP*GP*AP*GP*GP*AP*GP*A)-3', ... | Authors: | Ummat, A, Rechkoblit, O, Jain, R, Choudhury, J.R, Johnson, R.E, Silverstein, T.D, Buku, A, Lone, S, Prakash, L, Prakash, S, Aggarwal, A.K. | Deposit date: | 2012-03-28 | Release date: | 2012-05-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Structural basis for cisplatin DNA damage tolerance by human polymerase {eta} during cancer chemotherapy. Nat.Struct.Mol.Biol., 19, 2012
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7JK1
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7JKP
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7JL8
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7JKL
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7JLG
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7JTP
| Crystal structure of Protac MS67 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB | Descriptor: | Elongin-B, Elongin-C, GLYCEROL, ... | Authors: | Kottur, J, Jain, R, Aggarwal, A.K. | Deposit date: | 2020-08-18 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, 2021
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7JTO
| Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB | Descriptor: | 1,2-ETHANEDIOL, 3-methyl-N-(11-{[2-(4-{[4'-(4-methylpiperazin-1-yl)-3'-{[6-oxo-4-(trifluoromethyl)-5,6-dihydropyridine-3-carbonyl]amino}[1,1'-biphenyl]-3-yl]methyl}piperazin-1-yl)ethyl]amino}-11-oxoundecanoyl)-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, Elongin-B, ... | Authors: | Kottur, J, Jain, R, Aggarwal, A.K. | Deposit date: | 2020-08-18 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, 2021
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7L1X
| Structure of human CK2 alpha kinase (catalytic subunit) with the inhibitor 108600. | Descriptor: | (2~{Z})-6-[[2,6-bis(chloranyl)phenyl]methylsulfonyl]-2-[[4-oxidanyl-3-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]phenyl]methylidene]-4~{H}-1,4-benzothiazin-3-one, Casein kinase II subunit alpha, GLYCEROL, ... | Authors: | Rechkoblit, O, Aggarwal, A.K. | Deposit date: | 2020-12-15 | Release date: | 2021-08-11 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease. Nat Commun, 12, 2021
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4HTP
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4HTO
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2OH2
| Ternary Complex of Human DNA Polymerase | Descriptor: | 5'-D(*GP*GP*G*GP*GP*AP*AP*GP*GP*AP*CP*CP*C)-3', 5'-D(*TP*T*CP*CP*AP*GP*GP*GP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3', DNA polymerase kappa, ... | Authors: | Lone, S, Townson, S.A, Uljon, S.N, Prakash, S, Prakash, L, Aggarwal, A.K. | Deposit date: | 2007-01-09 | Release date: | 2007-02-27 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Ternary complex of the catalytic core of human DNA polymerase Kappa with DNA and dTT To be Published
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2P0J
| Structure of restriction endonuclease BstYI bound to non-cognate DNA | Descriptor: | 5'-D(*AP*TP*GP*AP*AP*TP*CP*CP*AP*TP*A)-3', 5'-D(*TP*AP*TP*GP*GP*AP*TP*TP*CP*AP*T)-3', BstYI | Authors: | Townson, S.A, Samuelson, J.C, Bao, Y, Xu, S.Y, Aggarwal, A.K. | Deposit date: | 2007-02-28 | Release date: | 2007-05-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | BstYI Bound to Noncognate DNA Reveals a "Hemispecific" Complex: Implications for DNA Scanning. Structure, 15, 2007
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