4EEY
Crystal structure of human DNA polymerase eta in ternary complex with a cisplatin DNA adduct
Summary for 4EEY
Entry DOI | 10.2210/pdb4eey/pdb |
Descriptor | DNA polymerase eta, 5'-D(*CP*TP*TP*GP*GP*TP*CP*TP*CP*CP*TP*CP*C)-3', 5'-D(*TP*GP*GP*AP*GP*GP*AP*GP*A)-3', ... (7 entities in total) |
Functional Keywords | dna replication, dna repair, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q9Y253 |
Total number of polymer chains | 3 |
Total formula weight | 56151.66 |
Authors | Ummat, A.,Rechkoblit, O.,Jain, R.,Choudhury, J.R.,Johnson, R.E.,Silverstein, T.D.,Buku, A.,Lone, S.,Prakash, L.,Prakash, S.,Aggarwal, A.K. (deposition date: 2012-03-28, release date: 2012-05-09, Last modification date: 2023-09-13) |
Primary citation | Ummat, A.,Rechkoblit, O.,Jain, R.,Roy Choudhury, J.,Johnson, R.E.,Silverstein, T.D.,Buku, A.,Lone, S.,Prakash, L.,Prakash, S.,Aggarwal, A.K. Structural basis for cisplatin DNA damage tolerance by human polymerase {eta} during cancer chemotherapy. Nat.Struct.Mol.Biol., 19:628-632, 2012 Cited by PubMed: 22562137DOI: 10.1038/nsmb.2295 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.32 Å) |
Structure validation
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