8V6M
Inactivated-state cryo-EM structure of human TRPV3 in presence of tetrahydrocannabivarin (THCV) in cNW30 nanodiscs
Summary for 8V6M
| Entry DOI | 10.2210/pdb8v6m/pdb |
| Related | 8V6K 8V6L |
| EMDB information | 42994 42995 42996 |
| Descriptor | Transient receptor potential cation channel subfamily V member 3, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Tetrahydrocannabivarin, ... (4 entities in total) |
| Functional Keywords | transient receptor potential v family member 3, trp, channel, trpv3, trp channels, membrane protein, tetrahydrocannabivarin, thcv |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 4 |
| Total formula weight | 381055.58 |
| Authors | Nadezhdin, K.D.,Neuberger, A.,Sobolevsky, A.I. (deposition date: 2023-12-01, release date: 2024-04-17, Last modification date: 2024-05-08) |
| Primary citation | Nadezhdin, K.D.,Neuberger, A.,Khosrof, L.S.,Talyzina, I.A.,Khau, J.,Yelshanskaya, M.V.,Sobolevsky, A.I. TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site. Sci Adv, 10:eadn2453-eadn2453, 2024 Cited by PubMed: 38691614DOI: 10.1126/sciadv.adn2453 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.63 Å) |
Structure validation
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