8V6M

Inactivated-state cryo-EM structure of human TRPV3 in presence of tetrahydrocannabivarin (THCV) in cNW30 nanodiscs

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Transient receptor potential cation channel subfamily V member 3	polymer	808	92680.0	4	UniProt (Q8NET8) Pfam (PF12796) Pfam (PF00023) Pfam (PF00520) In PDB	Homo sapiens (human)
2	A, B, C, D	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		760.1	12	Chemie (POV)
3	A, B, C, D	Tetrahydrocannabivarin	non-polymer		286.4	4	Chemie (I8E)
4	A	SODIUM ION	non-polymer		23.0	3	Chemie (NA)

Sequence modifications

A, B, C, D: 1 - 791 (UniProt: Q8NET8)

PDB	External Database	Details
Leu 792	-	expression tag
Val 793	-	expression tag
Pro 794	-	expression tag
Arg 795	-	expression tag
Gly 796	-	expression tag
Ser 797	-	expression tag
Ala 798	-	expression tag
Ala 799	-	expression tag
Ala 800	-	expression tag
Trp 801	-	expression tag
Ser 802	-	expression tag
His 803	-	expression tag
Pro 804	-	expression tag
Gln 805	-	expression tag
Phe 806	-	expression tag
Glu 807	-	expression tag
Lys 808	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	370720.1
Non-Polymers*	Number of molecules	19
	Total formula weight	10335.5
All*	Total formula weight	381055.6

*Water molecules are not included.