8V6M
Inactivated-state cryo-EM structure of human TRPV3 in presence of tetrahydrocannabivarin (THCV) in cNW30 nanodiscs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transient receptor potential cation channel subfamily V member 3 | polymer | 808 | 92680.0 | 4 | UniProt (Q8NET8) Pfam (PF12796) Pfam (PF00023) Pfam (PF00520) | Homo sapiens (human) | |
| 2 | E, F, H, L, M... (A, B, C, D) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 12 | Chemie (POV) | |||
| 3 | G, N, R, W (A, B, C, D) | Tetrahydrocannabivarin | non-polymer | 286.4 | 4 | Chemie (I8E) | |||
| 4 | I, J, K (A) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) |
Sequence modifications
A, B, C, D: 1 - 791 (UniProt: Q8NET8)
| PDB | External Database | Details |
|---|---|---|
| Leu 792 | - | expression tag |
| Val 793 | - | expression tag |
| Pro 794 | - | expression tag |
| Arg 795 | - | expression tag |
| Gly 796 | - | expression tag |
| Ser 797 | - | expression tag |
| Ala 798 | - | expression tag |
| Ala 799 | - | expression tag |
| Ala 800 | - | expression tag |
| Trp 801 | - | expression tag |
| Ser 802 | - | expression tag |
| His 803 | - | expression tag |
| Pro 804 | - | expression tag |
| Gln 805 | - | expression tag |
| Phe 806 | - | expression tag |
| Glu 807 | - | expression tag |
| Lys 808 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 370720.1 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 10335.5 | |
| All* | Total formula weight | 381055.6 |
