8E05

Structure of dimeric LRRK1

Summary for 8E05

Entry DOI	10.2210/pdb8e05/pdb
Related	8E04 8E06
EMDB information	27813 27814 27815 27816 27817 27818
Descriptor	Leucine-rich repeat serine/threonine-protein kinase 1, GUANOSINE-5'-DIPHOSPHATE (2 entities in total)
Functional Keywords	dimer, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	452364.84
Authors	Reimer, J.M.,Lin, Y.X.,Leschziner, A.E. (deposition date: 2022-08-08, release date: 2023-08-30, Last modification date: 2023-11-29)
Primary citation	Reimer, J.M.,Dickey, A.M.,Lin, Y.X.,Abrisch, R.G.,Mathea, S.,Chatterjee, D.,Fay, E.J.,Knapp, S.,Daugherty, M.D.,Reck-Peterson, S.L.,Leschziner, A.E. Structure of LRRK1 and mechanisms of autoinhibition and activation. Nat.Struct.Mol.Biol., 30:1735-1745, 2023 Cited by PubMed: 37857821 DOI: 10.1038/s41594-023-01109-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.6 Å)

Structure validation