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8E05

Structure of dimeric LRRK1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006468biological_processprotein phosphorylation
A0009966biological_processregulation of signal transduction
A0035556biological_processintracellular signal transduction
A0036035biological_processosteoclast development
A0042802molecular_functionidentical protein binding
A0045453biological_processbone resorption
A0046872molecular_functionmetal ion binding
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050732biological_processnegative regulation of peptidyl-tyrosine phosphorylation
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0106310molecular_functionprotein serine kinase activity
A1902533biological_processpositive regulation of intracellular signal transduction
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006468biological_processprotein phosphorylation
B0009966biological_processregulation of signal transduction
B0035556biological_processintracellular signal transduction
B0036035biological_processosteoclast development
B0042802molecular_functionidentical protein binding
B0045453biological_processbone resorption
B0046872molecular_functionmetal ion binding
B0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
B0050732biological_processnegative regulation of peptidyl-tyrosine phosphorylation
B0090263biological_processpositive regulation of canonical Wnt signaling pathway
B0106310molecular_functionprotein serine kinase activity
B1902533biological_processpositive regulation of intracellular signal transduction
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AASP1386
BASP1386

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU1248
ALYS1270
BLEU1248
BLYS1270

219869

PDB entries from 2024-05-15

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