8CTZ

12-mer DNA structure of ExBIM & O6Me-G bound to RNase-H

Summary for 8CTZ

• Entry DOI: 10.2210/pdb8ctz/pdb
• Descriptor: Ribonuclease H, DNA (5'-D(*CP*GP*CP*(6OG)P*AP*AP*TP*TP*(OWR)P*GP*CP*G)-3'), GLYCEROL, ... (8 entities in total)
• Functional Keywords: alkylation, base stacking, dna damage, h-bonding, o6-methyl-2'-deoxyguanosine, exbim, dna
• Biological source: Alkalihalobacillus halodurans; More
• Total number of polymer chains: 5
• Total formula weight: 57231.31

Authors

Pallan, P.S.,Egli, M. (deposition date: 2022-05-16, release date: 2022-08-31, Last modification date: 2023-10-18)

• Primary citation: Kellum Jr., A.H.,Pallan, P.S.,Nilforoushan, A.,Sturla, S.J.,Stone, M.P.,Egli, M.; Conformation and Pairing Properties of an O 6 -Methyl-2'-deoxyguanosine-Directed Benzimidazole Nucleoside Analog in Duplex DNA.; Chem.Res.Toxicol., 35:1903-1913, 2022; PubMed: 35973057; DOI: 10.1021/acs.chemrestox.2c00165

Experimental method

X-RAY DIFFRACTION (2.32 Å)