8ALY

Cryo-EM structure of human tankyrase 2 SAM-PARP filament (G1032W mutant)

Summary for 8ALY

• Entry DOI: 10.2210/pdb8aly/pdb
• EMDB information: 15520
• Descriptor: Poly [ADP-ribose] polymerase tankyrase-2, ZINC ION (2 entities in total)
• Functional Keywords: poly-adp-ribosyltransferase, enzyme, polymer, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 20
• Total formula weight: 682861.54

Authors

Mariotti, L.,Inian, O.,Desfosses, A.,Beuron, F.,Morris, E.P.,Guettler, S. (deposition date: 2022-08-01, release date: 2022-11-16, Last modification date: 2022-12-14)

• Primary citation: Pillay, N.,Mariotti, L.,Zaleska, M.,Inian, O.,Jessop, M.,Hibbs, S.,Desfosses, A.,Hopkins, P.C.R.,Templeton, C.M.,Beuron, F.,Morris, E.P.,Guettler, S.; Structural basis of tankyrase activation by polymerization.; Nature, 612:162-169, 2022; PubMed: 36418402; DOI: 10.1038/s41586-022-05449-8

Experimental method

ELECTRON MICROSCOPY (2.98 Å)