7Z2H
Cryo-EM structure of NNRTI resistant M184I/E138K mutant HIV-1 reverse transcriptase with a DNA aptamer in complex with doravirine
Summary for 7Z2H
Entry DOI | 10.2210/pdb7z2h/pdb |
Related | 7Z24 7Z29 7Z2D 7Z2E 7Z2G |
EMDB information | 14457 14458 14462 14463 14465 14466 |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, DNA (38-MER), ... (4 entities in total) |
Functional Keywords | reverse transcriptase mutant, rt-aptamer complex, nnrti resistance, non-nucleoside inhibitor, transferase |
Biological source | Human immunodeficiency virus type 1 BH10 More |
Total number of polymer chains | 3 |
Total formula weight | 126233.18 |
Authors | Singh, A.K.,Das, K. (deposition date: 2022-02-27, release date: 2022-07-20, Last modification date: 2022-10-12) |
Primary citation | Singh, A.K.,De Wijngaert, B.,Bijnens, M.,Uyttersprot, K.,Nguyen, H.,Martinez, S.E.,Schols, D.,Herdewijn, P.,Pannecouque, C.,Arnold, E.,Das, K. Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine. Proc.Natl.Acad.Sci.USA, 119:e2203660119-e2203660119, 2022 Cited by PubMed: 35858448DOI: 10.1073/pnas.2203660119 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.58 Å) |
Structure validation
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