7Z2E

Cryo-EM structure of NNRTI resistant M184I/E138K mutant HIV-1 reverse transcriptase with a DNA aptamer in complex with rilpivirine

Summary for 7Z2E

Entry DOI	10.2210/pdb7z2e/pdb
Related	7Z24 7Z29 7Z2D
EMDB information	14457 14458 14462 14463
Descriptor	Reverse transcriptase/ribonuclease H, p51 RT, DNA (38-MER), ... (4 entities in total)
Functional Keywords	reverse transcriptase mutant, rt-aptamer complex, nnrti resistance, non-nucleoside inhibitor, transferase
Biological source	Human immunodeficiency virus type 1 BH10 More
Total number of polymer chains	3
Total formula weight	126173.85
Authors	Singh, A.K.,Das, K. (deposition date: 2022-02-26, release date: 2022-07-20, Last modification date: 2022-08-03)
Primary citation	Singh, A.K.,De Wijngaert, B.,Bijnens, M.,Uyttersprot, K.,Nguyen, H.,Martinez, S.E.,Schols, D.,Herdewijn, P.,Pannecouque, C.,Arnold, E.,Das, K. Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine. Proc.Natl.Acad.Sci.USA, 119:e2203660119-e2203660119, 2022 Cited by PubMed: 35858448 DOI: 10.1073/pnas.2203660119 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.45 Å)

Structure validation