7UAH

Macrocyclic plasmin inhibitor

Summary for 7UAH

• Entry DOI: 10.2210/pdb7uah/pdb
• Descriptor: Plasminogen, (6S,9R,19S,22R)-N-{[4-(aminomethyl)phenyl]methyl}-22-[(3-chlorobenzene-1-sulfonyl)amino]-3,12,21-trioxo-2,6,9,13,20-pentaazatetracyclo[22.2.2.2~6,9~.2~14,17~]dotriaconta-1(26),14,16,24,27,29-hexaene-19-carboxamide, SULFATE ION, ... (5 entities in total)
• Functional Keywords: protease, inhibitor, complex, blood clotting
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 56675.93

Authors

Guojie, W. (deposition date: 2022-03-12, release date: 2023-03-15, Last modification date: 2023-10-25)

• Primary citation: Wiedemeyer, S.J.A.,Wu, G.,Pham, T.L.P.,Lang-Henkel, H.,Perez Urzua, B.,Whisstock, J.C.,Law, R.H.P.,Steinmetzer, T.; Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors.; Chemmedchem, 18:e202200632-e202200632, 2023; PubMed: 36710259; DOI: 10.1002/cmdc.202200632

Experimental method

X-RAY DIFFRACTION (1.57 Å)