7UAH

Macrocyclic plasmin inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU599-CYS604

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
A	HIS603
A	ASP646
A	ALA741
B	HIS603
B	ASP646
B	ALA741

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage; by plasminogen activator

Chain	Residue	Details
A	ARG561
B	ARG561

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:9201958

Chain	Residue	Details
A	SER578
B	SER578

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER669
B	SER669

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 425

Chain	Residue	Details
A	HIS603	proton shuttle (general acid/base)
A	ASP646	electrostatic stabiliser, modifies pKa
A	ALA741	covalent catalysis, proton shuttle (general acid/base)
A	GLY742	electrostatic stabiliser

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site_id	MCSA2
Number of Residues	4
Details	M-CSA 425

Chain	Residue	Details
B	HIS603	proton shuttle (general acid/base)
B	ASP646	electrostatic stabiliser, modifies pKa
B	ALA741	covalent catalysis, proton shuttle (general acid/base)
B	GLY742	electrostatic stabiliser

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