7T9I
Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)
Summary for 7T9I
| Entry DOI | 10.2210/pdb7t9i/pdb |
| EMDB information | 25758 |
| Descriptor | Glycoprotein hormones alpha chain, Thyrotropin subunit beta, Nanobody 35, ... (9 entities in total) |
| Functional Keywords | g protein-coupled receptor, thyroid-stimulating hormone receptor, thyrotropin receptor, tsh, thyroid, membrane protein |
| Biological source | Lama glama More |
| Total number of polymer chains | 7 |
| Total formula weight | 198810.57 |
| Authors | Faust, B.,Cheng, Y.,Manglik, A. (deposition date: 2021-12-19, release date: 2022-08-03, Last modification date: 2022-10-05) |
| Primary citation | Faust, B.,Billesbolle, C.B.,Suomivuori, C.M.,Singh, I.,Zhang, K.,Hoppe, N.,Pinto, A.F.M.,Diedrich, J.K.,Muftuoglu, Y.,Szkudlinski, M.W.,Saghatelian, A.,Dror, R.O.,Cheng, Y.,Manglik, A. Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature, 609:846-853, 2022 Cited by PubMed: 35940205DOI: 10.1038/s41586-022-05159-1 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
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