Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7T9I

Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005179molecular_functionhormone activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005796cellular_componentGolgi lumen
A0006590biological_processthyroid hormone generation
A0007186biological_processG protein-coupled receptor signaling pathway
A0008284biological_processpositive regulation of cell population proliferation
A0008406biological_processgonad development
A0009755biological_processhormone-mediated signaling pathway
A0010469biological_processregulation of signaling receptor activity
A0010893biological_processpositive regulation of steroid biosynthetic process
A0016913molecular_functionfollicle-stimulating hormone activity
A0016914cellular_componentfollicle-stimulating hormone complex
A0030335biological_processpositive regulation of cell migration
A0030878biological_processthyroid gland development
A0032275biological_processluteinizing hormone secretion
A0032870biological_processcellular response to hormone stimulus
A0035265biological_processorgan growth
A0042699biological_processfollicle-stimulating hormone signaling pathway
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046621biological_processnegative regulation of organ growth
A0046884biological_processfollicle-stimulating hormone secretion
A0048589biological_processdevelopmental growth
A0061696cellular_componentpituitary gonadotropin complex
B0005179molecular_functionhormone activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0007186biological_processG protein-coupled receptor signaling pathway
B0007267biological_processcell-cell signaling
B0009653biological_processanatomical structure morphogenesis
B0033189biological_processresponse to vitamin A
B0043627biological_processresponse to estrogen
B0051592biological_processresponse to calcium ion
R0004930molecular_functionG protein-coupled receptor activity
R0004996molecular_functionthyroid-stimulating hormone receptor activity
R0005886cellular_componentplasma membrane
R0007186biological_processG protein-coupled receptor signaling pathway
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0008344biological_processadult locomotory behavior
R0016020cellular_componentmembrane
R0016323cellular_componentbasolateral plasma membrane
R0016328cellular_componentlateral plasma membrane
R0016500molecular_functionprotein-hormone receptor activity
R0030183biological_processB cell differentiation
R0038194biological_processthyroid-stimulating hormone signaling pathway
R0040012biological_processregulation of locomotion
R0040018biological_processpositive regulation of multicellular organism growth
R0060119biological_processinner ear receptor cell development
R0060122biological_processinner ear receptor cell stereocilium organization
R0071542biological_processdopaminergic neuron differentiation
R0090103biological_processcochlea morphogenesis
R0120162biological_processpositive regulation of cold-induced thermogenesis
X0003924molecular_functionGTPase activity
X0005525molecular_functionGTP binding
X0007186biological_processG protein-coupled receptor signaling pathway
X0019001molecular_functionguanyl nucleotide binding
X0031683molecular_functionG-protein beta/gamma-subunit complex binding
Y0001750cellular_componentphotoreceptor outer segment
Y0003924molecular_functionGTPase activity
Y0005515molecular_functionprotein binding
Y0005737cellular_componentcytoplasm
Y0005765cellular_componentlysosomal membrane
Y0005829cellular_componentcytosol
Y0005834cellular_componentheterotrimeric G-protein complex
Y0005886cellular_componentplasma membrane
Y0007165biological_processsignal transduction
Y0007186biological_processG protein-coupled receptor signaling pathway
Y0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
Y0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
Y0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
Y0007265biological_processRas protein signal transduction
Y0008283biological_processcell population proliferation
Y0016020cellular_componentmembrane
Y0030159molecular_functionsignaling receptor complex adaptor activity
Y0044877molecular_functionprotein-containing complex binding
Y0045202cellular_componentsynapse
Y0050909biological_processsensory perception of taste
Y0051020molecular_functionGTPase binding
Y0060041biological_processretina development in camera-type eye
Y0070062cellular_componentextracellular exosome
Y0071380biological_processcellular response to prostaglandin E stimulus
Y0071870biological_processcellular response to catecholamine stimulus
Y0097381cellular_componentphotoreceptor disc membrane
Y1903561cellular_componentextracellular vesicle
Z0005515molecular_functionprotein binding
Z0005834cellular_componentheterotrimeric G-protein complex
Z0005886cellular_componentplasma membrane
Z0007165biological_processsignal transduction
Z0007186biological_processG protein-coupled receptor signaling pathway
Z0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
Z0016020cellular_componentmembrane
Z0031681molecular_functionG-protein beta-subunit binding
Z0048144biological_processfibroblast proliferation
Z0070062cellular_componentextracellular exosome
Z0071380biological_processcellular response to prostaglandin E stimulus
Z0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00261
Number of Residues7
DetailsGLYCO_HORMONE_BETA_1 Glycoprotein hormones beta chain signature 1. CAGYCmT
ChainResidueDetails
BCYS27-THR33

site_idPS00689
Number of Residues28
DetailsGLYCO_HORMONE_BETA_2 Glycoprotein hormones beta chain signature 2. PVAlsCkCgkCntdySDCiheaik..TnyC
ChainResidueDetails
BPRO78-CYS105

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
YLEU70-SER84
YILE157-ILE171
YLEU285-ALA299

site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. LSVyTLTVITLERWYaI
ChainResidueDetails
RLEU507-ILE523

site_idPS00779
Number of Residues13
DetailsGLYCO_HORMONE_ALPHA_1 Glycoprotein hormones alpha chain signature 1. CmGCCFSRAYPTP
ChainResidueDetails
ACYS28-PRO40

site_idPS00780
Number of Residues14
DetailsGLYCO_HORMONE_ALPHA_2 Glycoprotein hormones alpha chain signature 2. NHTaChCsTCyyHK
ChainResidueDetails
AASN78-LYS91

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
ZALA2
XLEU302
XPHE376
XASP223

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
ZCYS68

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
ZCYS68

219869

PDB entries from 2024-05-15

PDB statisticsPDBj update infoContact PDBjnumon