7QWK

GCN2 (EIF2ALPHA KINASE 4, E2AK4) IN COMPLEX WITH COMPOUND 2

Summary for 7QWK

• Entry DOI: 10.2210/pdb7qwk/pdb
• Related: 7QQ6
• Descriptor: eIF-2-alpha kinase GCN2, (2~{S})-~{N}-[(1~{S})-1-[4-[(6-pyridin-4-ylquinazolin-2-yl)amino]phenyl]ethyl]piperidine-2-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
• Functional Keywords: gcn2, eif2 kinase, isr, integrated stress response, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 296900.77

Authors

Maia de Oliveira, T. (deposition date: 2022-01-25, release date: 2022-05-04, Last modification date: 2024-02-07)

• Primary citation: Maia de Oliveira, T.,Korboukh, V.,Caswell, S.,Winter Holt, J.J.,Lamb, M.,Hird, A.W.,Overman, R.; The structure of human GCN2 reveals a parallel, back-to-back kinase dimer with a plastic DFG activation loop motif.; Biochem.J., 477:275-284, 2020; PubMed: 31868900; DOI: 10.1042/BCJ20190196

Experimental method

X-RAY DIFFRACTION (2.3 Å)