7QWK
GCN2 (EIF2ALPHA KINASE 4, E2AK4) IN COMPLEX WITH COMPOUND 2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | eIF-2-alpha kinase GCN2 | polymer | 318 | 36640.5 | 8 | UniProt (Q9P2K8) Pfam (PF00069) In PDB | Homo sapiens (human) | Eukaryotic translation initiation factor 2-alpha kinase 4,GCN2-like protein |
2 | A, B, C, D, E... | (2~{S})-~{N}-[(1~{S})-1-[4-[(6-pyridin-4-ylquinazolin-2-yl)amino]phenyl]ethyl]piperidine-2-carboxamide | non-polymer | 452.6 | 8 | Chemie (G41) | |||
3 | H | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
4 | water | water | 18.0 | 84 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 577 - 1020 (UniProt: Q9P2K8)
PDB | External Database | Details |
---|---|---|
- | Pro 662 | deletion |
- | Ala 663 | deletion |
- | Gly 664 | deletion |
- | Pro 665 | deletion |
- | Gly 666 | deletion |
- | Thr 667 | deletion |
- | Pro 668 | deletion |
- | Pro 669 | deletion |
- | Pro 670 | deletion |
- | Asp 671 | deletion |
- | Ser 672 | deletion |
- | Gly 673 | deletion |
- | Pro 674 | deletion |
- | Leu 675 | deletion |
- | Ala 676 | deletion |
- | Lys 677 | deletion |
- | Asp 678 | deletion |
- | Asp 679 | deletion |
- | Arg 680 | deletion |
- | Ala 681 | deletion |
- | Ala 682 | deletion |
- | Arg 683 | deletion |
- | Gly 684 | deletion |
- | Gln 685 | deletion |
- | Pro 686 | deletion |
- | Ala 687 | deletion |
- | Ser 688 | deletion |
- | Asp 689 | deletion |
- | Thr 690 | deletion |
- | Asp 691 | deletion |
- | Gly 692 | deletion |
- | Leu 693 | deletion |
- | Asp 694 | deletion |
- | Ser 695 | deletion |
- | Val 696 | deletion |
- | Glu 697 | deletion |
- | Ala 698 | deletion |
- | Ala 699 | deletion |
- | Ala 700 | deletion |
- | Pro 701 | deletion |
- | Pro 702 | deletion |
- | Pro 703 | deletion |
- | Ile 704 | deletion |
- | Leu 705 | deletion |
- | Ser 706 | deletion |
- | Ser 707 | deletion |
- | Ser 708 | deletion |
- | Val 709 | deletion |
- | Glu 710 | deletion |
- | Trp 711 | deletion |
- | Ser 712 | deletion |
- | Thr 713 | deletion |
- | Ser 714 | deletion |
- | Gly 715 | deletion |
- | Glu 716 | deletion |
- | Arg 717 | deletion |
- | Ser 718 | deletion |
- | Ala 719 | deletion |
- | Ser 720 | deletion |
- | Ala 721 | deletion |
- | Arg 722 | deletion |
- | Phe 723 | deletion |
- | Pro 724 | deletion |
- | Ala 725 | deletion |
- | Thr 726 | deletion |
- | Gly 727 | deletion |
- | Pro 728 | deletion |
- | Gly 729 | deletion |
- | Ser 730 | deletion |
- | Ser 731 | deletion |
- | Asp 732 | deletion |
- | Asp 733 | deletion |
- | Glu 734 | deletion |
- | Asp 735 | deletion |
- | Asp 736 | deletion |
- | Asp 737 | deletion |
- | Glu 738 | deletion |
- | Asp 739 | deletion |
- | Glu 740 | deletion |
- | His 741 | deletion |
- | Gly 742 | deletion |
- | Gly 743 | deletion |
- | Val 744 | deletion |
- | Phe 745 | deletion |
- | Ser 746 | deletion |
- | Gln 747 | deletion |
- | Ser 748 | deletion |
- | Phe 749 | deletion |
- | Leu 750 | deletion |
- | Pro 751 | deletion |
- | Ala 752 | deletion |
- | Ser 753 | deletion |
- | Asp 754 | deletion |
- | Ser 755 | deletion |
- | Glu 756 | deletion |
- | Ser 757 | deletion |
- | Asp 758 | deletion |
- | Ile 759 | deletion |
- | Ile 760 | deletion |
- | Phe 761 | deletion |
- | Asp 762 | deletion |
- | Asn 763 | deletion |
- | Glu 764 | deletion |
- | Asp 765 | deletion |
- | Glu 766 | deletion |
- | Asn 767 | deletion |
- | Ser 768 | deletion |
- | Lys 769 | deletion |
- | Ser 770 | deletion |
- | Gln 771 | deletion |
- | Asn 772 | deletion |
- | Gln 773 | deletion |
- | Asp 774 | deletion |
- | Glu 775 | deletion |
- | Asp 776 | deletion |
- | Cys 777 | deletion |
- | Asn 778 | deletion |
- | Glu 779 | deletion |
- | Lys 780 | deletion |
- | Asn 781 | deletion |
- | Gly 782 | deletion |
- | Cys 783 | deletion |
- | His 784 | deletion |
- | Glu 785 | deletion |
- | Ser 786 | deletion |
- | Glu 787 | deletion |
Asn 848 | Asp 848 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 293124.1 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 3776.7 | |
All* | Total formula weight | 296900.8 |