7QQ6

GCN2 (EIF2ALPHA KINASE 4, E2AK4) IN COMPLEX WITH COMPOUND 1 (dovitinib)

Summary for 7QQ6

Entry DOI	10.2210/pdb7qq6/pdb
Descriptor	eIF-2-alpha kinase GCN2, 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one (3 entities in total)
Functional Keywords	eif2 kinase, integrated stress response, gcn2, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	148708.28
Authors	Maia de Oliveira, T. (deposition date: 2022-01-06, release date: 2022-03-02, Last modification date: 2024-01-31)
Primary citation	Maia de Oliveira, T.,Korboukh, V.,Caswell, S.,Winter Holt, J.J.,Lamb, M.,Hird, A.W.,Overman, R. The structure of human GCN2 reveals a parallel, back-to-back kinase dimer with a plastic DFG activation loop motif. Biochem.J., 477:275-284, 2020 Cited by PubMed: 31868900 DOI: 10.1042/BCJ20190196 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation