7OLM

Dioxygenase AsqJ mutant (V72I) in complex with 2b-O-O and Tris

Summary for 7OLM

Entry DOI	10.2210/pdb7olm/pdb
Related	5DAP
Descriptor	Iron/alpha-ketoglutarate-dependent dioxygenase asqJ, NICKEL (II) ION, 3-[(S)-dioxidanyl(phenyl)methyl]-4-methyl-2-oxidanyl-1H-1,4-benzodiazepin-5-one, ... (7 entities in total)
Functional Keywords	quinolone biosynthesis, molecular engineering, epoxidation, catalytic mechanism, oxidoreductase
Biological source	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Total number of polymer chains	1
Total formula weight	34601.40
Authors	Auman, D.,Mader, S.L.,Ecker, F.,Dorst, K.,Braeuer, A.,Widmalm, G.,Groll, M.,Kaila, V.R.I. (deposition date: 2021-05-20, release date: 2022-06-01, Last modification date: 2024-01-31)
Primary citation	Auman, D.,Ecker, F.,Mader, S.L.,Dorst, K.M.,Brauer, A.,Widmalm, G.,Groll, M.,Kaila, V.R.I. Peroxy Intermediate Drives Carbon Bond Activation in the Dioxygenase AsqJ. J.Am.Chem.Soc., 144:15622-15632, 2022 Cited by PubMed: 35980821 DOI: 10.1021/jacs.2c05650 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation