6PKC

Inhibition of Human Menin by VTP-50469

Summary for 6PKC

• Entry DOI: 10.2210/pdb6pkc/pdb
• Descriptor: Menin,Menin, 5-fluoro-2-({4-[7-({trans-4-[(methylsulfonyl)amino]cyclohexyl}methyl)-2,7-diazaspiro[3.5]nonan-2-yl]pyrimidin-5-yl}oxy)-N,N-di(propan-2-yl)benzamide (3 entities in total)
• Functional Keywords: human menin, transcription, inhibitor complex, vtp-50469
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 110996.01

Authors

McKeever, B.M.,Chen, G.,Van Orton, R. (deposition date: 2019-06-29, release date: 2019-12-18, Last modification date: 2023-10-11)

• Primary citation: Krivtsov, A.V.,Evans, K.,Gadrey, J.Y.,Eschle, B.K.,Hatton, C.,Uckelmann, H.J.,Ross, K.N.,Perner, F.,Olsen, S.N.,Pritchard, T.,McDermott, L.,Jones, C.D.,Jing, D.,Braytee, A.,Chacon, D.,Earley, E.,McKeever, B.M.,Claremon, D.,Gifford, A.J.,Lee, H.J.,Teicher, B.A.,Pimanda, J.E.,Beck, D.,Perry, J.A.,Smith, M.A.,McGeehan, G.M.,Lock, R.B.,Armstrong, S.A.; A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia.; Cancer Cell, 36:660-673.e11, 2019; PubMed: 31821784; DOI: 10.1016/j.ccell.2019.11.001

Experimental method

X-RAY DIFFRACTION (1.9 Å)